A study of corrosive esophagitis

Johnson, Ernest E.

doi:10.1288/00005537-196312000-00006

Cited by 56 publications

(9 citation statements)

References 21 publications

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“…In 1950, Spain and his colleagues (15, 16) reported that the early administration of cortisone has an antiinflammatory effect on granulation tissue by inhibiting fibroplasia. Following experimental studies on dogs, cats and rats, other researchers have supported the same statement (6,10,12,14).…”

Section: Discussionmentioning

confidence: 94%

The Effect of Steroid Treatment on Corrosive Oesophageal Burns in Children*

Keskin

Okur²,

Koltuksuz³

et al. 1991

Eur J Pediatr Surg

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A retrospective study was done on corrosive oesophageal burns to ascertain the preventive effect of corticosteroids on stricture development. Within the last 12 years 351 children were admitted to our medical centre with a history of corrosive agent ingestion. In 235 of these the diagnosis of oesophageal burn was confirmed by means of oesophagoscopy. Children admitted within the first 48 hours received steroid, antibiotic and fluid therapy while fluid and antibiotics were given, if needed, in the rest. Forty-six of the children were lost to follow-up. The type of corrosive agent, the admission period, the degree of the burn and the stricture development were used as parameters. Stricture development was found statistically significant in late admitted patients vs. early admissions. This retrospective study suggests the effectiveness of corticosteroid treatment in preventing the stricture development.

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Section: Discussionmentioning

confidence: 94%

The Effect of Steroid Treatment on Corrosive Oesophageal Burns in Children*

Keskin

Okur²,

Koltuksuz³

et al. 1991

Eur J Pediatr Surg

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“…The degree of esophageal injury was retrospectively categorized (3,lO) as: grade 0 = normal esophagoscopy; grade I = mucosal injury-reddening, edema; grade I1 = submucosal injury-deep ulceration and graywhitish pseudomembrane; and grade 111 = transmural injury-deep ulceration and black-brown necrosis. In addition, injuries were graded as: (a) non-circumferential or (b) (near)-circumferential (2,11,12).…”

Section: Methodsmentioning

confidence: 99%

Prediction of complications following unintentional caustic ingestion in children. Is endoscopy always necessary?

Christesen

1995

Acta Paediatrica

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The records of 115 children hospitalized following caustic ingestion over an 18.5-year period from 1976 to 1994 were reviewed. The relationship between types of product ingested, signs and symptoms, degree of esophageal injury and complications was analyzed. All complications were the result of strong alkali ingestion (sensitivity = 1.0). Among the 102 incident patients, 36.8% of lye ingestions resulted in complications, whereas only 2.7% (one) of automatic dishwasher detergent (ADD) ingestions caused any complications (p < 0.01). Endoscopy 6 h to 4 days after injury was accurate in predicting or identifying complications in all types of strong alkali ingestions. In lye ingestions, endoscopy was not superior to the test, "one or more signs or symptoms" in predicting complications (predictivity = 1.0). Endoscopy is recommended to establish or confirm a prognosis, or to identify acute respiratory complications, in symptomatic ingestions of lye or ammonia water, in children with respiratory symptoms, and in rare cases of severe symptoms following ADD or strong acid ingestion. It is suggested that children who are non-symptomatic following unintentional ingestions are not at risk of complications and do not need endoscopic examination.

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“…Stricture formation occurs due to fibrous tissue production and collagen deposition in the esophageal wall, leading to narrowing of the esophageal lumen. Both circumferential and longitudinal collagen deposition has been demonstrated after corrosive esophageal injury 11 . The esophageal wall gets markedly thickened secondary to this deposition 4 .…”

Section: Discussionmentioning

confidence: 99%

Can high-frequency mini-probe endoscopic ultrasonography predict outcome of endoscopic dilation in patients with benign esophageal strictures?

et al. 2020

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Background and study aims Endoscopic dilation is first-line management for benign esophageal strictures (ES). Depth of involvement of the esophageal wall on endosonography using high frequency mini-probe (EUS-M) may predict response to dilation. This study evaluated EUS-M characteristics to predict response of ES to endoscopic dilation. Patients and methods EUS-M was used to measure the total esophageal wall thickness (EWT), involved EWT, percentage of involved wall and layers of wall involved in consecutive patients of benign ES. After a maximum of five sessions of endoscopic dilation, the cohort was divided into responders and refractory strictures. EUS-M characteristics were compared for underlying etiology as also between responders and refractory strictures. Results Of the 30 strictures (17 females, age: 47.16 ± 15.86 yrs.) 13 were anastomotic, eight corrosive, seven peptic and 2 others. Corrosive strictures had the highest involved EWT and percentage of involved wall (3.51 ± 1.36 mm; 76.38 %) followed by anastomotic (2.73 ± 1.7 mm; 65.54 %) and peptic (1.39 ± 0.62 mm; 40.71 %) (P = 0.026 and 0.021 respectively). After five dilations, 22 were classified as responders and eight as refractory. Wall involvement > 70 % had a greater proportion of refractory strictures (P = 0.019). Strictures with involved EWT of ≥ 2.85 mm required more dilations (P = 0.011). Fewer dilations were required for stricture resolution with only mucosal involvement compared to deeper involvement such as submucosa and muscularis propria (2.14 vs. 5.80; P = 0.001). Conclusion EUS-M evaluation shows that corrosive and anastomotic strictures have greater depth of involvement compared to peptic strictures. Depth of esophageal wall involvement in a stricture predicts response to dilation.

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A study of corrosive esophagitis

Cited by 56 publications

References 21 publications

The Effect of Steroid Treatment on Corrosive Oesophageal Burns in Children*

The Effect of Steroid Treatment on Corrosive Oesophageal Burns in Children*

Prediction of complications following unintentional caustic ingestion in children. Is endoscopy always necessary?

Can high-frequency mini-probe endoscopic ultrasonography predict outcome of endoscopic dilation in patients with benign esophageal strictures?

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