A study of effect of &amp;lt;i&amp;gt;Nigella sativa&amp;lt;/i&amp;gt; oil in paracetamol induced hepatotoxicity in albino rats

Ghadlinge, Manik; Jaju, Jugalkishor B.; Chandane, Rakhamaji D.; Jadhav, Rakesh R.; Bhosle, Rama R.

doi:10.5455/2319-2003.ijbcp20140624

Cited by 4 publications

(2 citation statements)

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“…15 Paracetamol overdose may cause severe hepatotoxicity and sometimes even fatal liver failure and centrilobular hepatic necrosis in humans and experimental animals. 16 …”

Section: Hepatoprotective Studiesmentioning

confidence: 99%

Hepatoprotective activity of ethanol extract of Pavetta Indica Linn leaves

Valte¹,

Singh²,

Raleng³

et al. 2018

Int J Basic Clin Pharmacol

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Background: Traditionally, the bark of Pavetta Indica Linn., in decoction or pulverized, is administered, especially to children, to correct visceral obstructions. The decocted leaves are used externally to alleviate the pains caused by hemorrhoids. The root, pulverized and mixed with the ginger and rice-water, is given in dropsy. A local fomentation with the leaves is useful in relieving the pain of piles. Paracetamol (PCM) toxicity generates free radicals and raised serum enzyme levels-SGPT, SGOT, Alkaline Phosphatase and S. Albumin. It causes necrosis, congested vessels, multifocal area of fatty changes nuclear disintegration, sinusoidal dilation, kuffer cell hyperplasia. The reverse is considered as the index of hepatoprotective activity. The present study is being taken up to screen hepatoprotective action of P. Indica Linn.Methods: The acute liver damage in albino rats was induced by per oral administration of a single dose of 2000mg/kg b.w. PCM suspension in 0.5% Carboxy methyl cellulose (CMC) and chronic liver damage by giving the same dose of PCM on the 7th day. The hepatoprotective activity was monitored biochemically by estimating S. transaminase, S. bilirubin and S. Protein on the 8th day of experiment.Results: Ethanol extract of P. Indica inhibited PCM induced liver toxicity in albino rats at 100mg/kg and 200mg/kg b.w as assessed by the biochemical values.Conclusions: Ethanol extract of “P. Indica” exhibited significant hepatoprotective activity.

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“…15 Paracetamol overdose may cause severe hepatotoxicity and sometimes even fatal liver failure and centrilobular hepatic necrosis in humans and experimental animals. 16 …”

Section: Hepatoprotective Studiesmentioning

confidence: 99%

Hepatoprotective activity of ethanol extract of Pavetta Indica Linn leaves

Valte¹,

Singh²,

Raleng³

et al. 2018

Int J Basic Clin Pharmacol

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“…It has been demonstrated that THY produced a variety of pharmacological actions such as anti-inflammatory, anticancer, and antioxidant [14,15]. Numerous studies found that THY may have a protective effect against acute hepatotoxicity caused by paraquat [16], acetaminophen [17], cisplatin [18], and CCl 4 [19]. However, fewer studies have focused on its protective mechanism against hepatotoxicity when DOX is administered.…”

Section: Introductionmentioning

confidence: 99%

Thymoquinone Prevents Doxorubicin-induced Hepatic-injury by Mitigating the Impairment of Mitochondrial Respiration and Electron Transport

Madani¹,

Burzangi²,

Alkreathy³

et al. 2022

Int J Pharm Res Allied Sci

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Doxorubicin (DXR) is an anthracycline antibiotic that is commonly used in cancer treatment. The purpose of this study was to see if Thymoquinone (THY) could reduce the hepatotoxic effects of doxorubicin. All animals were divided into four groups: control (Phosphate buffer i.p. 0.5mlkg -1 /day), THY (10mgkg -1 /i.p/daily), doxorubicin (20mgkg -1 /i.p/single dose), THY (10mgkg -1 /i.p/daily) + DOX(20mgkg -1 /i.p/single dose on Day 7). Changes in hepatic enzymes in serum ALT, AST, and GGT, as well as tests for free radical metabolism enzymes such as Cu, Zn-SOD, CAT, and MDA were carried out in all animals that received treatments. In addition, the inflammatory markers IL-6, Nf-kB, and TNF-alpha were measured in liver tissue homogenate. Caspase, an apoptosis marker, was also measured. The liver enzymes were significantly elevated in DOX treated rats as compared to all treated groups. Thymoquinone pretreatment significantly reduced the level of hepatic enzymes as compared to DOX. Comparison of the DOX-treated group to the control group showed that SOD and catalase activities rose significantly. In the DOX-treated group, malondialdehyde levels were higher than in the control and all-treatment groups, respectively (P<0.05). The THY + DOX group had lower levels of malondialdehyde, SOD, and catalase activity than the DOX-group (P<0.05). Anti-inflammatory markers , as well as Caspase 3 (p<0.0001), reduced in THY-treated rats, were found to be significantly lower in THY-treated rats (P<0.0001). Biochemical findings were supported by histopathological studies. We conclude that by modulating ROS, inflammation, and apoptosis, thymoquinone significantly reduces DOX-induced hepatotoxicity in rats.

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