A Study of Factor XHIa and MAC 387 Immunolabeling in Normal and Pathological Skin

Cerio, R.; Spaull, J.; Oliver, G. Fergus; Jones, E. Wilson

doi:10.1097/00000372-199006000-00002

Cited by 154 publications

(80 citation statements)

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“…It is also used as a diagnostic marker in various dermatological diseases ranging from inflammatory lesions such as psoriasis, eczema, spongiotic dermatoses, lichen planus, toxic epidermal necrolysis, and uricaria, to malignancies such as dermatofibromas, Kaposi's sarcomas, basal cell carcinomas and malignant melanomas [4,10,[12][13][14][15][16][17][18][19]]. …”

Section: +mentioning

confidence: 99%

“…The elevated dermal expression of FXIII-A in the inflammatory skin diseases such as psoriasis, eczema, spongiotic dermatoses, lichen planus, toxic epidermal necrolysis, and uricaria was observed [4,10,[12][13][14][15][16][17][18][27][28][29]. Migration of FXIII-A-positive inflammatory macrophages and dermal dendrocytes in association with other inflammatory cells into the epidermal compartment in chronic plaque psoriasis was reported.…”

Section: Fxiii-a In Inflammatory Skin Lesionsmentioning

confidence: 99%

“…The role of FXIII-A in antigen presentation and its relationship to the expression of antigen presenting molecules CD1 and MHC II were suggested. Other studies showed that FXIII-A is considered as a positive disease-nonspecific marker of skin lesions with a possible common mechanism of dermal dendrocytes, macrophages, lymphocytes and plasma activity [14,19,30].…”

Section: Fxiii-a In Inflammatory Skin Lesionsmentioning

confidence: 99%

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The role of factor XIII-A in the development of inflammatory skin lesions

2014

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Factor XIII (FXIII) is a unique clotting factor activated in the last stage of the coagulation cascade, with multiple other plasmatic and cellular functions, outside of the traditional homeostasis. Literature data show that FXIII is expressed in skin lesions in the course of various inflammatory skin disorders. Dermis contains a series of macrophages and dendritic cells, which express different phenotypes including FXIII. Increased levels of FXIII-positive cells are present in specific cutaneous inflammatory and fibrotic conditions. The aim of this review is to provide the relationship between FXIII and the development of the inflammatory skin lesions.

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Section: +mentioning

confidence: 99%

Section: Fxiii-a In Inflammatory Skin Lesionsmentioning

confidence: 99%

Section: Fxiii-a In Inflammatory Skin Lesionsmentioning

confidence: 99%

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The role of factor XIII-A in the development of inflammatory skin lesions

2014

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“…In the skin, Factor XIIIa + DD are normally confined to the dermis, with greater quantities present within the papillary dermis, at the dermo-epidermal junction, and in loose areolar connective tissue around the appendages, particularly the pilosebaceous units and abutted to vessels (1,(12)(13)(14). High numbers of these cells are present in the septa between fat lobules.…”

Section: Factor Xiiia + Cellsmentioning

confidence: 99%

“…The antigenic epitope of Factor XIIIa is localised predominantly in the cytoplasm of the specific DD, with some membraneous labeling (14). Factor XIIIa + DD exhibit structural aspects depending on their location in the dermis.…”

Section: Factor Xiiia + Cellsmentioning

confidence: 99%

Molecular mapping of Factor XIIIa-enriched dendrocytes in the skin (Review)

Piérard¹

1998

Int J Mol Med

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Abstract. The human dermis contains a series of dendritic cells which express different phenotypes including Factor XIIIa immunoreactivity. This compound is related to a blood coagulation factor participating in angiogenesis, in the final stages of the clotting cascade and in wound healing. In normal skin, Factor XIIIa is expressed in specific dermal dendrocytes (DD) derived from the monocyte/macrophage lineage or from a mesenchymal origin. DD are located predominantly around the microvasculature in the adventitial dermis, at the dermo-epidermal junction, and around skin appendages, but normally not within the epidermis. Increased numbers of Factor XIIIa + DD are present in a host of specific cutaneous inflammatory and fibrotic conditions. In tumor pathology, immunophenotypic differences are found between dermatofibromas and other fibrohistiocytic entities, most notably dermatofibrosarcoma protuberans. In addition, Factor XIIIa + DD are likely to be involved in the progression and regression of some malignancies including cutaneous melanoma and basal cell carcinoma.

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The Human Progenitor Cell Antigen (CD34) Is Localized on Endothelial Cells, Dermal Dendritic Cells, and Perifollicular Cells in Formalin-Fixed Normal Skin, and on Proliferating Endothelial Cells and Stromal Spindle-Shaped Cells in Kaposi's Sarcoma

1991

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The human progenitor cell antigen (CD34) is selectively expressed on hematopoietic progenitor cells in the bone marrow. In either cryostat sections of snap-frozen skin, or formalin-fixed paraffin-embedded sections of normal skin, anti-CD34 monoclonal antibody immunostained vascular endothelial cells and perivascular/interstitial dendritic cells, particularly in the reticular dermis. A distinctive population of perifollicular spindle-shaped cells in the midportion of the follicle (ie, bulge area), which is the site of the putative hair follicle stem cells, were CD34 positive, as were spindle-shaped cells in and around the eccrine glands accentuating their basement membrane zone. In patch/plaque--and tumor-stage acquired immunodeficiency syndrome-associated Kaposi's sarcoma lesions, CD34 expression was present on both the proliferating endothelial cells as well as the spindle-shaped stromal cells. CD34 positive endothelial cells and spindle-shaped stromal cells may play important participatory and supportive functions in both normal and diseased skin.

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A Study of Factor XHIa and MAC 387 Immunolabeling in Normal and Pathological Skin

Cited by 154 publications

References 0 publications

The role of factor XIII-A in the development of inflammatory skin lesions

The role of factor XIII-A in the development of inflammatory skin lesions

Molecular mapping of Factor XIIIa-enriched dendrocytes in the skin (Review)

The Human Progenitor Cell Antigen (CD34) Is Localized on Endothelial Cells, Dermal Dendritic Cells, and Perifollicular Cells in Formalin-Fixed Normal Skin, and on Proliferating Endothelial Cells and Stromal Spindle-Shaped Cells in Kaposi's Sarcoma

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