A study of glucose tolerance, serum transaminase and lipids in women using depot-medroxyprogesterone acetate and a combination-type oral contraceptive

Progestin-only contraceptives: effects on weight

“…The retrospective study of Tuchman 2005 focused on adolescents and young women, ages 12 to 21 years. At 6 and 12 months, the DMPA group was similar to the group using medroxyprogesterone acetate (MPA) plus E 2 C and to the COC users for mean weight change and mean percentage weight change (Tuchman 2005). In the small study of Tankeyoon 1976, the DMPA and COC groups were not significantly different in the proportions that gained at least 1 kg by months 6 and 12.…”

“…Ten prospective studies included five RCTs (WHO 1983;Salem 1988;Ball 1991;Westhoff 2007) and five with other prospective designs (Tankeyoon 1976;Castle 1978;Salem 1984 The progestin-only contraceptives examined were as follows:…”

Progestin-only contraceptives: effects on weight

“…At 6 and 12 months, the DMPA group was similar to the group using medroxyprogesterone acetate (MPA) plus E2C and to the COC users for mean weight change and mean percentage weight change (Tuchman 2005). In the small study of Tankeyoon 1976, the DMPA and COC groups were similar in the proportions that gained at least 1 kg by months 6 and 12. For weight loss of 1 kg or more, the groups were slightly different at six months but the confidence interval was very wide.…”

“…The nine prospective studies included five RCTs (WHO 1983; Salem 1988; Ball 1991; Sivin 1998; Westhoff 2007) and four with other prospective designs (Tankeyoon 1976; Castle 1978; Salem 1984; Bonny 2009). Six studies used retrospective data (Moore 1995; Taneepanichskul 1998; Espey 2000; Sule 2005; Tuchman 2005; Pantoja 2010).…”

“…Three were prospective studies (RCTs or non-randomized) For Tankeyoon 1976, the COC group was reduced by 25%. In Castle 1978, losses to follow up were 39% (DMPA 150) versus 23% (DMPA 450).…”