Progestin-only contraceptives: effects on weight

Lopez, Laureen M; Edelman, Alison; Chen-Mok, Mario; Helmerhorst, Frans M.

doi:10.1002/14651858.cd008815.pub2

Cited by 16 publications

(10 citation statements)

References 59 publications

(78 reference statements)

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“…9 Our findings also are supported by a recent Cochrane review of the effects of progestin-only contraceptives on weight where the authors concluded, “[W]e found little evidence of weight gain when using progestin-only contraceptives. Mean gain was less than 2 kg for most studies up to 12 months, and usually similar for the comparison group using another contraceptive.” 2 …”

Section: Discussionmentioning

confidence: 99%

“…1 Prior studies have shown weight gain and changes in body composition among users of depo-medroxyprogesterone acetate (DMPA), progestin-only pills, and the subdermal levonorgestrel implant. 2 Therefore, it is plausible that newer, long-acting progestin contraceptives may also cause weight gain. However, there are fewer studies investigating weight change with these methods, which include the etonogestrel (ENG) implant and the levonorgestrel intrauterine system (LNG-IUS).…”

Section: Introductionmentioning

confidence: 99%

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Weight change at 12 months in users of three progestin-only contraceptive methods

et al. 2013

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Background Concerns about weight gain may influence contraceptive use. We compared the change in body weight over the first 12 months of use between women using the etonogestrel (ENG) implant, the levonorgestrel intrauterine system (LNG-IUS), or depot medroxyprogesterone acetate (DMPA) with women using the copper intrauterine device (IUD). Study Design This was a substudy of the Contraceptive CHOICE Project, a prospective cohort study of 9256 women provided no-cost contraception. Women who had been using the ENG implant, LNG-IUS, DMPA, or copper IUD continuously for at least 11 months were eligible for participation. We obtained body weight at enrollment and at 12 months and compared the weight change for each progestin-only method to the copper IUD. Results We enrolled a total of 427 women: 130 ENG implant users, 130 LNG-IUS users, 67 DMPA users, and 100 copper IUD users. The mean weight change (in kilograms) over 12 months was 2.1 for ENG implant users (standard deviation [SD] 6.7); 1.0 for LNG-IUS users (SD 5.3); 2.2 for DMPA users (SD 4.9); and 0.2 for copper IUD users (SD 5.1). The range of weight change was broad across all contraceptive methods. In the unadjusted linear regression model, ENG implant and DMPA use was associated with weight gain compared to the copper IUD. However, in the adjusted model, no difference in weight gain with the ENG implant, LNG-IUS, or DMPA was observed. Only black race was associated with significant weight gain (1.3 kg, 95% CI 0.2-2.4) when compared to other racial groups. Conclusions Weight change was variable among women using progestin-only contraceptives. Black race was a significant predictor of weight gain among contraceptive users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Weight change at 12 months in users of three progestin-only contraceptive methods

et al. 2013

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“…Concerns about changes in menstrual patterns, weight gain [26] and effects on bone mineral density [27–29] have deterred some physicians [30] and patients [22] from recommending and using this method of contraception. Data from the 2006–2008 cycle of National Survey on Family Growth showed that current DMPA use among all reproductive-age women in the United States decreased to 2.0%, from 3.3% in 2002 [22].…”

Section: Discussionmentioning

confidence: 99%

Associations between recent contraceptive use and quality of life among women

et al. 2012

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Background Whether contraception affects health-related quality of life (HRQoL) is unclear. Study Design Cross-sectional analysis of routine intake data collected from women aged 18–50 years, including the RAND-36 measure of HRQoL, pregnancy intentions, and recent contraceptive use. We used multivariable logistic regression to test the relationship between HRQoL and use of any and specific contraceptives. Physical and mental HRQoL were dichotomized based on U.S. population averages. Models were adjusted for age, race, marital status, education and pregnancy intentions. Results Among the 726 women, those using any form of contraception were more likely to have average or better mental HRQoL than women using no contraception (adjusted odds ratio (aOR)=1.60, 95% confidence interval (CI) 1.01, 2.53). Women using injectable contraception were less likely than those using combined hormonal methods to have average or better physical HRQoL (aOR=0.26, 95% CI 0.09, 0.80) and mental-HRQoL (aOR=0.24, 95% CI 0.06, 0.86). Conclusions Measures of women’s HRQoL differ with contraceptive use.

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“…In particular, the average weight gain was less than 2 kg. Two studies demonstrated a greater increase in fat body mass and decrease in lean body mass compared to non-hormonal methods [135]. Another review indicated that overweight and obese adolescent women using depot medroxyprogesterone acetate (DMPA) were more prone to develop weight gain than normal weight DMPA users or overweight subjects not using DMPA.…”

Section: Oral Contraceptivesmentioning

confidence: 99%

Common Medications Which Lead to Unintended Alterations in Weight Gain or Organ Lipotoxicity

Medici

McClave

Miller

2015

Curr Gastroenterol Rep

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Obesity is one of the most common chronic conditions in the world. Its management is difficult, partly due to the multiple associated comorbidities including fatty liver, diabetes, hypertension, and hyperlipidemia. As a result, the choice of prescription medications in overweight and obese patients has important implications as some of them can actually worsen the fat accumulation and its associated metabolic complications. Several prescription medications are associated with weight gain with mechanisms that are often poorly understood and under-recognized. Even less data are available on the distribution of fat and lipotoxicity (the organ damage related to fat accumulation). The present review will discuss the drugs associated with weight gain, their mechanism of action, and the magnitude and timing of their effect.

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Progestin-only contraceptives: effects on weight

Cited by 16 publications

References 59 publications

Weight change at 12 months in users of three progestin-only contraceptive methods

Weight change at 12 months in users of three progestin-only contraceptive methods

Associations between recent contraceptive use and quality of life among women

Common Medications Which Lead to Unintended Alterations in Weight Gain or Organ Lipotoxicity

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