A study of Helicobacter pylori infection, dietary pattern and habits in patients with gastric cancer in South India

Laroiya, Ishita; Ss, Pankaja; Kate, Vikram

doi:10.1016/s2222-1808(12)60006-1

Cited by 9 publications

(7 citation statements)

References 15 publications

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“…Resent researches suggested that a high intake of salt (sodium) could increase the risk of GC [21], [24]–[26]. It was also evidenced by our observation that the GC patients in Jiangsu province were preference for salty foods, such as salted meat, pickled vegetables, and pickled vegetable juice, which might be contaminated by N-nitroso compounds.…”

Section: Discussionsupporting

confidence: 55%

Association among Polymorphisms in EGFR Gene Exons, Lifestyle and Risk of Gastric Cancer with Gender Differences in Chinese Han Subjects

Zhang

Zhan

et al. 2013

PLoS ONE

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BackgroundThe epidermal growth factor receptor (EGFR) gene plays a key role in tumor survival, invasion, angiogenesis, and metastatic spread. Recent studies showed that gastric cancer (GC) was associated with polymorphisms of the EGFR gene and environmental influences, such as lifestyle factors. In this study, seven known SNPs in EGFR exons were investigated in a high-risk Chinese population in Jiangsu province to test whether genetic variants of EGFR exons and lifestyle are associated with an increased risk of GC.Methodology/Principal FindingsA hospital-based case-control study was performed in Jiangsu province. The results showed that smoking, drinking and preference for salty food were significantly associated with the risk of GC. The differences of lifestyle between males and females might be as the reason of higher incidence rates in males than those in females. Seven exon SNPs were genotyped rs2227983,rs2072454,rs17337023,rs1050171,rs1140475, rs2293347, and rs28384375. It was noted that the variant rs2072454 T allele and TT genotype were significantly associated with an increased risk of GC. Interestingly, our result suggested the ACAGCA haplotype might be associated with decreased risk of GC. However, no significant association was examined between the other six SNPs and the risk of GC both in the total population and the age-matching population even with gender differences.ConclusionsSmoking, drinking and preference for salty food were significantly associated with the risk of GC in Jiangsu province with gender differences. Although only one SNP (rs2072454) was significantly associated with an increased risk of GC, combined the six EGFR exon SNPs together may be useful for predicting the risk of GC.

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Section: Discussionsupporting

confidence: 55%

Association among Polymorphisms in EGFR Gene Exons, Lifestyle and Risk of Gastric Cancer with Gender Differences in Chinese Han Subjects

Zhang

Zhan

et al. 2013

PLoS ONE

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“…Namely, GC risk was closely correlated to high intake of salted or fried foods, dried fish and meat, eating fast, smoking and drinking, while fresh fruits and tea played a protective role in the high incidence area of east China. Some studies suggested that lifestyle factors play an important role in triggering the development of GC, such as preferring to salty foods, smoking and drinking (13,14). These results indicated that lifestyle shape the human metabolism and inflammation, for instance, a nationwide case-control study showed that lifestyle related inflammation was associated with an increased risk of oesophageal cancer, regardless of histological type (15).…”

Section: Introductionmentioning

confidence: 99%

Relationship between serum inflammatory cytokines and lifestyle factors in gastric cancer

Sun

Xiang

et al. 2019

mol clin onc

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Chronic inflammation is associated with increased risk of gastric cancer (GC), and GC risk is significantly associated with lifestyle. The aim of the present study was to explore the association between serum inflammatory cytokines and lifestyle factors in GC. A total of 20 serum inflammatory cytokines were measured in a hospital-based case-control population with 142 GC patients and 98 healthy controls. Controls without the selected healthy lifestyle factors were regarded as baseline, and correlation analysis was conducted to establish the association between serum inflammatory cytokines and lifestyle factors. The results demonstrated that several lifestyle factors (including eating fried and salty foods, eating quickly, smoking and drinking) could increase the risk of GC, while only eating fresh fruits could decrease the risk of GC. Correlation analysis revealed that increased serum interleukin (IL)-12/IL-23P40 levels was associated with GC risk as significant differences were observed in all lifestyle factors. Increased serum IL-8 was closely associated with smoking in GC patients, while increased IL-17α and IL-8 levels were associated with GC patients who ate salty foods. Increased IL-10 and decreased TGF-β levels were also associated with GC patients who ate fresh fruits. In conclusion, GC risk was strongly affected by lifestyle factors, which may regulate the expression of inflammatory cytokines and promote gastric carcinogenesis.

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“…Therefore, examination of dietary patterns, which assess the effects of overall diet and determined by factor analysis can be proxy indicators of real food consumption and availability, providing a more realistic representation of everyday eating habits16. Previous studies demonstrated that dietary patterns were associated with prevalence of gastric cancer1718. But no study has yet investigated the association between Helicobacter pylori infection and dietary patterns.…”

mentioning

confidence: 99%

Dietary Patterns are Associated with Helicobacter Pylori Infection in Chinese Adults: A Cross-Sectional Study

Yang

Meng

Zhang

et al. 2016

Sci Rep

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Previous studies indicated that food consumption was associated with Helicobacter pylori infection, but no study has yet investigated the association between Helicobacter pylori infection and dietary patterns. The aim of this study was to evaluate the associations between Helicobacter pylori infection and dietary patterns in Tianjin, China. The final cross-sectional study population comprised 10407 participants. Dietary consumption of participants was assessed via food frequency questionnaire. Factor analysis was used to identify dietary patterns, and Helicobacter pylori infection status was diagnosis by H. pylori urease Immunogold Testing kit. Participants in the highest quartile of the high-carbohydrate/sweet pattern showed a multivariable-adjusted OR (95% CI) of 1.65 (1.27–2.17) for the prevalence of H. pylori infection compared with those in the lowest quartile. The multiple adjusted OR for scores of the extreme quartile of high-protein/cholesterol pattern was 0.75 (95% CI, 0.57–0.98). This study demonstrated that a diet rich in carbohydrates and sweets was positively associated with the prevalence of H. pylori infection; interestingly, a diet characterized by high intake of animal offal, animal blood, fish, seafood, and poultry was associated with a reduction of prevalence of H. pylori infection.

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A study of Helicobacter pylori infection, dietary pattern and habits in patients with gastric cancer in South India

Cited by 9 publications

References 15 publications

Association among Polymorphisms in EGFR Gene Exons, Lifestyle and Risk of Gastric Cancer with Gender Differences in Chinese Han Subjects

Association among Polymorphisms in EGFR Gene Exons, Lifestyle and Risk of Gastric Cancer with Gender Differences in Chinese Han Subjects

Relationship between serum inflammatory cytokines and lifestyle factors in gastric cancer

Dietary Patterns are Associated with Helicobacter Pylori Infection in Chinese Adults: A Cross-Sectional Study

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