Dietary Patterns are Associated with Helicobacter Pylori Infection in Chinese Adults: A Cross-Sectional Study

Abstract

Previous studies indicated that food consumption was associated with Helicobacter pylori infection, but no study has yet investigated the association between Helicobacter pylori infection and dietary patterns. The aim of this study was to evaluate the associations between Helicobacter pylori infection and dietary patterns in Tianjin, China. The final cross-sectional study population comprised 10407 participants. Dietary consumption of participants was assessed via food frequency questionnaire. Factor analysis was used to identify dietary patterns, and Helicobacter pylori infection status was diagnosis by H. pylori urease Immunogold Testing kit. Participants in the highest quartile of the high-carbohydrate/sweet pattern showed a multivariable-adjusted OR (95% CI) of 1.65 (1.27–2.17) for the prevalence of H. pylori infection compared with those in the lowest quartile. The multiple adjusted OR for scores of the extreme quartile of high-protein/cholesterol pattern was 0.75 (95% CI, 0.57–0.98). This study demonstrated that a diet rich in carbohydrates and sweets was positively associated with the prevalence of H. pylori infection; interestingly, a diet characterized by high intake of animal offal, animal blood, fish, seafood, and poultry was associated with a reduction of prevalence of H. pylori infection.

Dietary habits and Helicobacter pylori infection: a cross sectional study at a Lebanese hospital

“…A convenience sampling method was used to select participants, thereby limiting the ability to generalize results to the target population. Potential misclassification bias of the main outcome although minimal is possible, Serological testing, could be improved further by using stains having higher sensitivity and specificity than H&E stain such as Giemsa stain, Warthin-Starry silver stain, Genta stain, and immunohistochemical (IHC) (69–93% and 87–90% respectively, versus 90–100%) [ 52 , 53 ]. Moreover, the FFQ administered presents some limitations.…”

Decreasing prevalence of Helicobacter pylori according to birth cohorts in urban China

“…pylori urease-IgG antibodies were serologically detected using a specific ELISA kit, the Hp Urease Immunogold Testing Kit (Beijing Kangmeitianhong Biotechnology Co., Ltd., Beijing, China). The ELISA kit had a sensitivity of 98.91% and specificity of 98.29% for detecting H. pylori in the populations tested (11).…”

Intake of Oxidized Proteins and Amino Acids and Causative Oxidative Stress and Disease: Recent Scientific Evidences and Hypotheses

“…Other authors have consistently observed 2 to 3‐fold levels of protein carbonyls in plasma from H. pylori ‐infected patients compared to healthy counterparts, with these values being reliable indicators of the severity, the prognosis, and the efficacy of the treatment (Ma et al., ; Rajendiran, Zachariah, & Hamide, ). The oxidation of red meat in the stomach infected by H. pylori and the subsequent input of dietary protein carbonylation to the carbonylation of the gastric mucosa may contribute to explaining the profuse number of epidemiological studies linking red meat consumption and H. pylori gastritis (Epplein et al., ; Xia et al., ). The formation of protein carbonyls is irreversible and oxidized proteins are accumulated in injured tissues sustaining the chronicity of the pathological conditions that may eventually lead to the oxidative DNA damage and the neoplasic transformation (Figure ).…”