A study of hematological profile in dengue fever at tertiary care center, Kota Rajasthan, India

Meena, Kamlesh; Jelia, Shivcharan; Meena, Shivraj; Arif, Mohd.; Ajmera, Devendra; Jatav, Vinod S.

doi:10.18203/2349-3933.ijam20162506

Cited by 19 publications

(35 citation statements)

References 3 publications

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“…18,21 An analysis of white cell counts showed a range of 1.1x10 9 /l to 14.3x10 9 /l, in accordance with other studies. 2,7 Leucopenia (<4 x10 9 /l) 7 was noted in 36% in accordance with other studies. 7,11,12,17,21 A few studies used a threshold of <5x10 9 /l for leucopenia.…”

Section: Discussionsupporting

confidence: 92%

“…1,2,4,15,16,18,25 A normal leucocyte count was observed in 55% of cases in our study in concordance with few studies but it was lower and higher in other studies. 2,4,15,18,21,24 Leucocytosis was noted in 9% of cases in our study in concordance with few studies. 25 It was seen in lower and higher proportion of cases in other studies.…”

Section: Discussionsupporting

confidence: 91%

“…5 Dengue presents with a wide clinical spectrum which includes undifferentiated fever, Classic Dengue, Dengue Hemorrhagic Fever and Dengue Shock Syndrome. 2 It may be confused with other febrile illnesses like Malaria, Typhoid, Leptospirosis, Chikungunya, Cox sackie, Infectious Mononucleosis, Rickettsia, Rubella, Influenza etc. So, clinical diagnosis in early phase is difficult.…”

Section: Introductionmentioning

confidence: 99%

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The total leucocyte count: its utility in dengue

2017

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Background: Dengue infections are public health concerns in India, where they occur in epidemics and have a high mortality in the advanced stages. Clinical features are nonspecific, and diagnosis is supported by lab features. One of these lab tests include total leucocyte count-easily available, simple and cost effective which is useful in small rural set ups for early diagnosis and prognosis of dengue. The aim of this study is to analyse the total leucocyte count patterns in dengue and assess its utility as early marker of dengue and prognosticator of severe dengue.Methods: A total of 132 serologically proven cases of dengue with total white cell counts (blood counts obtained by Automated hematology analyser) during November 2016 were analysed.Results: In our study, most cases were noted in the younger age group with a male predominance. The range of total leucocyte count was 1.1x109 /l to 14.3x109/l. Most (55%) had normal counts, leucopenia was noted in 36%, had an equal distribution in all ages and both sexes. 82% had mild leucopenia,52% of leucopenia cases were associated with severe thrombocytopenia. Almost half (47%) of leucopenia cases were NS1 positive while only 15% were antibody positive.59% of NS1 positive had leucopenia in contrast to 13% of antibody positive cases. While leucopenia was mostly (55%) associated with neutrophilia, lymphocytosis was seen in 74% of cases with a normal leucocyte count.Conclusions: Total leucocyte count is one of the simple, easily available, cost effective tests useful in small rural set ups for early diagnosis and prognosis in dengue and helps reduce the morbidity and mortality of dengue.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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The total leucocyte count: its utility in dengue

2017

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“…In another study by Kailash C Meena et al the percentage of patients with raised hematocrit was 9.8%. 10 The percentage of patients with raised hematocrit in our study was 9.8% which was similar to Kailash C Meena' s study.…”

Section: Discussionsupporting

confidence: 91%

Retrospective study of white blood cell count and hematocrit in dengue fever

2018

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Background: Dengue is an extremely important tropical disease transmitted by the Aedes aegypti mosquito. Aim of the study: to study the white blood cell levels in serologically proven dengue cases; to study hematocrit levels in cases of dengue fever.Methods: The present study is a retrospective observational analysis of white blood cell count (WBC count) and hematocrit in 235 serologically proven Dengue cases admitted in the years 2011-2012Results: 107 cases (45.5%) had leukopenia, 111 cases (47.2%) had normal WBC counts and 12 cases had leukocytosis (5.1%). 23 cases had increased hematocrit (9.8%), 76 cases had a low hematocrit (32.3%) and 128 cases had a normal hematocrit (54.5%).Conclusions: A significant proportion of patients had leukopenia which may be an early marker of dengue infection. Only a small percentage of patients had raised hematocrit. It may be that rise from baseline levels of haematocrit which may be more significant than absolute values.

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“…5,6,10,[16][17][18] Present study explores this line of thought by drawing parallels between the degree of atypical lymphocytosis and thrombocytopenia, and thus the progression to severe dengue; as thrombocytopenia has been associated with bleeding tendencies and increased vascular leakage with shock. [3][4][5]9,11,20 Aim of this study is to assess the utility of simple, easily available tests like platelet counts and atypical lymphocytes as predictors of severity in dengue.…”

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confidence: 99%

Correlation of thrombocytopenia with degree of atypical lymphocytosis as a prognostic indicator in dengue

2017

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Background: Dengue viral infections may occur as epidemics and are of public health concern in India especially due to high mortality in advanced stages. Early diagnosis and treatment reduces the mortality significantly. To assess the utility of atypical lymphocyte counts with relation to platelet counts as a marker for severe dengue.Methods: A total of 132 serologically proven (by rapid card method) cases of dengue with atypical lymphocytosis (≥10%) and thrombocytopenia (<150×109/l) were analyzed during November 2016. The complete blood counts (obtained from automated hematology analyzer and Leishman stained peripheral smears) were analyzed.Results: Dengue infections were mostly seen in younger age (12-25 years) with slight male predominance. The relevant haematology findings noted were leukopenia in 36% and severe thrombocytopenia (<50×109/l) in 57% of cases. The differential count showed lymphocytosis in 64% with significant (≥20%) atypical lymphocytes in 52% which inversely correlated with platelet counts. Atypical lymphocytosis (≥20%) was noted in 9% of cases with mild as against 32% of severe thrombocytopenia.Conclusions: Atypical lymphocyte count can be used as predictor of severe thrombocytopenia and severe dengue. This helps in early diagnosis and proper management and drastic reduction in mortality.

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A study of hematological profile in dengue fever at tertiary care center, Kota Rajasthan, India

Cited by 19 publications

References 3 publications

The total leucocyte count: its utility in dengue

The total leucocyte count: its utility in dengue

Retrospective study of white blood cell count and hematocrit in dengue fever

Correlation of thrombocytopenia with degree of atypical lymphocytosis as a prognostic indicator in dengue

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