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Background: Dengue is an exceedingly common infection of the tropics. The aim of the research to study the biochemical parameters of serologically proven dengue cases.Methods: The study included Dengue patients admitted in PSG Hospital between January 2011and December 2012.Results: Analysis of aspartate aminotransferase results showed that 19.1% had two-fold rise, 13.3% had three-fold rise and 19.6% had more than threefold rise. Analysis of alanine aminotransferase showed that 35.7% had normal values, 14.95% had two-fold rise, 11.1% had three-fold rise and 11.5% had more than threefold rise. Serum proteins were normal in 35.7% and low in 19.6%. Analysis of serum albumin showed low values in 10.6% Serum sodium levels were low in 11.1% of patients. Albuminuria was positive in 53% of patients. Serum ionised calcium levels were low in 26.8% of patients.Conclusions: The biochemical abnormalities noted in our study included include elevated liver enzymes, low sodium and ionised calcium levels, hypoalbuminemia and increased urine albumin excretion.

Background: Dengue fever is an exceedingly common tropical infection in India. It can affect the liver with a wide spectrum of manifestations. The aim of the study was to analyse the liver function tests derangement in serologically proven dengue cases.Methods: Patients who were Dengue IgM positive were included in this study. All the patients underwent liver function tests.Results: Of 1oo patients, 33% had less than 2-fold increase in ALT levels, 18% had 2-4-fold increase, 20% had 4-10-fold increase and 11% had more than 10-fold increase. Overall 18% had normal values and 82% had values of ALT above normal. With regard to AST 8% had normal values, 26% had less than 2-fold normal, 26% had 2-4-fold increase, 25% had 4-10-fold increase and 15% had greater than 10-fold increase. 92% of patients had values above normal. Bilirubin levels were elevated in 5% of cases. Alkaline phosphatase levels were elevated in 25% of cases; serum globulins were increased in 9% of cases. Serum proteins were low in 43% of cases and serum albumin was low in 31% of cases.Conclusions: The spectrum of hepatic involvement in dengue fever can vary from asymptomatic biochemical involvement to severe acute liver cell injury. Hyperbilirubinemia may also be observed. Low albumin levels may be present and may be a marker of the critical phase of the disease.

Background: Dengue is an extremely important tropical disease transmitted by the Aedes aegypti mosquito. Aim of the study: to study the white blood cell levels in serologically proven dengue cases; to study hematocrit levels in cases of dengue fever.Methods: The present study is a retrospective observational analysis of white blood cell count (WBC count) and hematocrit in 235 serologically proven Dengue cases admitted in the years 2011-2012Results: 107 cases (45.5%) had leukopenia, 111 cases (47.2%) had normal WBC counts and 12 cases had leukocytosis (5.1%).  23 cases had increased hematocrit (9.8%), 76 cases had a low hematocrit (32.3%) and 128 cases had a normal hematocrit (54.5%).Conclusions: A significant proportion of patients had leukopenia which may be an early marker of dengue infection. Only a small percentage of patients had raised hematocrit. It may be that rise from baseline levels of haematocrit which may be more significant than absolute values.

Background: Dengue infection is an extremely common infection in tropical countries. It is considered to be prevalent all-round the year. The aim of the study was to analyse the ultrasound features of serologically proven dengue cases. To correlate the platelet count with ultrasound features of dengue.Methods: Study included dengue patients admitted from January 2011 to December 2012. Dengue was diagnosed by IgM antibody test. All patients underwent ultrasound evaluation and platelet count testing.Results: most common finding was ascites in 43 cases (39.8%), splenomegaly in 41 cases (37.9%), right sided pleural effusion in 25 cases (23.4%), gall bladder wall thickening was present in 30 cases (27.7%) and hepatomegaly was present in 20 cases (18.5%). Presence of most of the features of ultrasound evaluation correlated with a platelet count of less than 40000 cells/mm3.Conclusions: The commonest sonographic findings were ascites and splenomegaly followed by pleural effusion and gall bladder wall thickening. Thus, presence of these ultrasound features in a febrile patient may be suggestive of dengue fever and presence of all the sonographic features may suggest a low platelet count.