Retrospective analysis of biochemical profile of dengue infection in a tertiary care hospital

Narasimhan, Denesh; Katragadda, Silpita

doi:10.18203/2320-6012.ijrms20175131

Cited by 2 publications

(3 citation statements)

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“…Different electrolytes have variable prevalence in different parts of the world. The prevalence of hyponatremia in dengue is ranging from 11% to 58% globally 6,7 . Hypokalemia is reported in 11% 7 including case reports of acute hypokalemic quadriparesis complicated with hypomagnesemia 8 .…”

Section: Introductionmentioning

confidence: 99%

Altered Electrolyte Homeostasis and the Severity of Dengue in Children

2021

PJMD

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Background: Dengue is the commonest arboviral disease that is endemic in our country. Electrolyte imbalance is commonly encountered in this disease. There had been only a few worldwide research studies investigating at all the metabolic parameters of dengue infection. Therefore, the study aimed to assess the electrolyte imbalance and its correlation with the severity of dengue fever in pediatrics. Methods:This cross-sectional study was carried out in the Pediatric Department of Ziauddin Hospital over 18 months. Diagnosed patients through detection of Dengue NS1 antigen or serology of dengue fever from 6 months to 18 years of age were enrolled and their history, hematological and electrolyte values (sodium, potassium, calcium, magnesium, and phosphate) were analyzed. Data was analyzed by SPSS and a Chi-squared test was used to compare the frequency of electrolyte disturbances between patients. A p-value <0.05 was considered statistically significant.Results: A higher incidence of dengue fever was observed in the younger age group (81)54 %. The majority of the patients showed mild hyponatremia 82(54.6%), mild hypokalemia 63(42%) and hypocalcemia 96(64 %). Hypophosphatemia 98(65.3 %) (p-value 0.045) was found more compared to hypomagnesemia 22(14.6%). Fever was observed in 100% of patients along with body aches 90(60%), drowsiness 31(20.7%) and abdominal pain 16(10.7%). We also found leucopenia 48(32%) and thrombocytopenia 127(84.6%), whereas hematocrit 30(20 %) was also raised. Conclusion:Majority of electrolytes (sodium, potassium, calcium and phosphate) were found decreased in dengue patients. However, hyponatremia (p=0.001) and hypophosphatemia (p=0.045) were significantly associated to the severity of dengue.

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Section: Introductionmentioning

confidence: 99%

Altered Electrolyte Homeostasis and the Severity of Dengue in Children

2021

PJMD

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“…Dengue is a mosquito-borne arboviral infection transmitted by infected Aedes mosquito. 1 It is one of the most common and potentially fatal infections in tropical and subtropical countries. 2 The incidence of Dengue fever has raised exponentially in the past 5 decades, and there are about 2.5 billion people living in dengue-endemic areas worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…3 Dengue had been endemic in 16 states in India and after 2010 has been present in all states. 1 No specific treatment is available, and the mainstay of treatment is careful fluid management, specific organ support and correction of metabolic and electrolyte derangement. 2 Involvement of multiple organs, including kidneys, is found in complex cases.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Microbiological Profile of Type 2 Diabetic Patients With Urinary Tract Infections

Deepa

Lakshmaiah

Prabhakar

et al. 2019

IJMBS

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Background: Dengue is one of the most common and potentially fatal infections in tropical and subtropical countries. Our study aims to compare serum electrolytes between dengue cases and non-dengue fever cases presenting to a tertiary care hospital. Methods: This case control study was conducted in a tertiary health care hospital between October 2017 to December 2018. Cases were considered as serologically confirmed cases of dengue and controls were those with fever cases other than dengue. All the study participants were selected by convenient sampling. The study included 54 dengue cases and 50 non-dengue controls. Sodium, Potassium electrolytes were considered outcome variables. Results and Discussion: The sodium level in dengue and non-dengue groups were in the level of 134.7-139 and 136-140, respectively. The potassium level in dengue and non-dengue groups were 3.6 -4.3 and 3.6 -4.65, respectively. In dengue group, 41(75.9%) patients had normal sodium level, and 13(24.1%) had a low level of sodium whereas, in the non-dengue group, 48(96%) had normal sodium level and 2(4%) had a low level of sodium. In dengue group, 47(87%) patients had normal potassium level, and 7(13%) had a low level of potassium whereas, in the non-dengue group, 43(86%) had normal potassium level and 7(14%) had a low level of potassium. Conclusions: Dengue increases the risk of electrolyte imbalances, including hyponatremia and hypokalemia. They may be associated with poor treatment outcomes. Routine screening of dengue patients for electrolytes may help the clinicians in risk stratification of patients.

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Retrospective analysis of biochemical profile of dengue infection in a tertiary care hospital

Cited by 2 publications

References 4 publications

Altered Electrolyte Homeostasis and the Severity of Dengue in Children

Altered Electrolyte Homeostasis and the Severity of Dengue in Children

Clinical and Microbiological Profile of Type 2 Diabetic Patients With Urinary Tract Infections

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