Analysis of liver function tests in dengue fever

Narasimhan, Denesh; Ponnusamy, Pasupathi; Sathish, M.

doi:10.18203/2349-3933.ijam20175500

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…92% of patients had values above normal. 19 Bilirubin levels were elevated in 5% of cases. Soni A et al, observed that rearranged serum SGOT and/or SGPT was present in 98.9% of patients.…”

Section: Discussionmentioning

confidence: 96%

Evaluation of hepatocellular dysfunction and its association with severity in dengue patients

Dutta

Kumar

et al. 2019

Int J Adv Med

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Background: Dengue is a mosquito-borne infection that in recent years has become an important disease of international public health concern. Dengue virus infections and illness when symptomatic, that patients tend to present with a significantly wide variety manifestations. The aim of the study was to evaluate liver dysfunction in patients with dengue infections.Methods: The present study was undertaken as an observational cross-sectional study the period June 2017 to December 2018. The details of all patients with serologically proved dengue fever admitted in the hospital were reviewed. Data including routine blood count, liver function test (LFT), prothrombin time (PT), activated partial prothrombin time (APTT), abdominal ultrasonography was studied. Statistical analysis: Data was analyzed using SPSS version 21.0. Difference between proportions was tested by using chi square test. Pearson correlation coefficient was used to measure linear correlation between two continuous variables. A p value <0.05 was consideredstatistically significant.Results: Majority of the study participants were in the age group of 16-30 years (57.5%) and were males (64.5%). Fever, Headache and joint pain were the most common symptoms noted among the study participants. Majority of the study participants were found to have elevated levels of SGOT (75.3%), SGPT (64.2%) levels and lower levels ofserum albumin (68.6%) on evaluation. Statistically significant association was observed between elevated liver enzymes and presence of features of dengue haemorrhagic fever.Conclusions: Considerably high proportion of patients with dengue infection were found to have hepatic dysfunction in the form of deranged liver enzymes.

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“…92% of patients had values above normal. 19 Bilirubin levels were elevated in 5% of cases. Soni A et al, observed that rearranged serum SGOT and/or SGPT was present in 98.9% of patients.…”

Section: Discussionmentioning

confidence: 96%

Evaluation of hepatocellular dysfunction and its association with severity in dengue patients

Dutta

Kumar

et al. 2019

Int J Adv Med

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“…This reversal of AST:ALT ratio was not seen in other viral infections including infection with HAV, HBV, HCV, etc., but was observed in cases of alcoholic hepatitis. 11,12 Hence, with the concurrent presence of thrombocytopenia, fever, and icterus, it acts as a differentiating clue from other viral hepatitis mimics. 13 However, since AST is produced from other sources apart from the liver such as the heart, striated muscle, and erythrocytes, the increased value noted in dengue fever may not be a true reflection of hepatic involvement.…”

Section: Discussionmentioning

confidence: 99%

The continuum of liver injury with severity of dengue fever: A retrospective observational study

Mohindra,

Kalyan

et al. 2023

Journal of the Royal College of Physicians of Edinburgh

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Introduction: Dengue is a major international health concern prevalent in tropical and sub-tropical countries. There are a paucity of studies on the relationship of hepatic complications with inflammatory parameters in dengue infection. Patients and methods: Single-centre observational study was conducted at the tertiary care centre in North India. Patients (>12 years) diagnosed with dengue infection between August and November 2021 were enrolled in the study. The frequency of hepatic derangements and their associations with inflammatory severity was analysed. Results: Based on the clinical symptoms, 170 patients were classified into three categories, namely, dengue fever, warning dengue and severe dengue. Higher incidence of liver dysfunction was observed in severe dengue patients with median values of aspartate aminotransferase (AST) (3051 U/L, p < 0.001), alanine aminotransferase (ALT) (1792 U/L, p = 0.009), alkaline phosphatase (172 U/L, p = 0.001), T.Bil (34.2 µmol/L, p < 0.001), albumin (30 g/L, <0.001), and gamma-glutamyl transferase (152 U/L, p < 0.001) along with inflammatory marker C-reactive protein (CRP) (43 mg/dL, p < 0.001) highly deranged, in comparison to patients with/without warning signs. Median levels of CRP were found to be positively and significantly correlated with the median levels of AST and ALT ( p < 0.05, r = 0.99) in all three categories of dengue patients. Liver injury was noted in 107 (63%) of the cohort, and mixed type of liver injury involving both hepatocellular and cholestatic patterns was observed as the most common type of injury ( n = 50, 29.4%). Liver injury correlated with the severity of dengue illness as about 85% of severe dengue patients had significant liver injury ( p = 0.014). Conclusion: In dengue patients, the association of the liver injury with inflammatory severity suggests that the mechanism of liver injury may be related to inflammatory response apart from the hepatotropic nature of the virus.

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“…Binary logistic regression also performed to assess the combined ability of two transaminases and combination with age and sex for the patients who showed either of maximum transaminases elevation for 3 categories (Normal, between 5 and tenfold rise and greater than tenfold rise) [ 8 , 9 ] during the febrile phase of the disease. Data was analysed by SPSS (Version 22).…”

Section: Introductionmentioning

confidence: 99%

Predictive value of hepatic transaminases during febrile phase as a predictor of a severe form of Dengue: analysis of adult Dengue patients from a tertiary care setting of Sri Lanka

et al. 2021

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Objectives Dengue viral infection is an ongoing epidemic in Sri Lanka, causing significant mortality and morbidity. A descriptive-analytical study was carried out using serologically confirmed Dengue patients during a 6 month period. The relationship between the elevation of hepatic enzymes and severity of Dengue was assessed after stratifying recorded maximum AST/ALT (SGOT/SGPT) values 2–15 times elevated and by the phases of the illness. Sensitivity, specificity, predictive values, and ROC curves were assessed using maximum values for AST and ALT. Results Out of 255 patients, 107(42%) were females. The majority (52.9%) were in the 20–39 year age group. Only 19.6% had DHF. No statistically significant difference was noticed in the values of maximum transaminases during the febrile phase among DF and DHF patients. Higher sensitivity and low specificity with the 1–5 times elevation range was noticed, and a higher cut-off level of more than 5 times elevation showed low sensitivity and higher specificity. The combination of both transaminases cut-offs with age and sex also does not show clinically significant predictability of severe disease. The AST and ALT elevations are not showing discriminatory predictive value on dengue severity. As different serotypes cause different epidemics, it is important to carry out large-scale specific studies considering the serotypes.

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Analysis of liver function tests in dengue fever

Cited by 4 publications

References 3 publications

Evaluation of hepatocellular dysfunction and its association with severity in dengue patients

Evaluation of hepatocellular dysfunction and its association with severity in dengue patients

The continuum of liver injury with severity of dengue fever: A retrospective observational study

Predictive value of hepatic transaminases during febrile phase as a predictor of a severe form of Dengue: analysis of adult Dengue patients from a tertiary care setting of Sri Lanka

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