A Study of Hormonal Profile (Luteinizing Hormone, Estrogen, Follicle Stimulating Hormone and Prolactin) In the Women Suffering From Acne Vulgaris

Abstract

Background: Acne vulgaris is a pilosebaceous gland disease usually affecting people from puberty to young adulthood due to hormonal changes, but the exact relationship of various hormone to acne is not known. Aims:-The present study has been planned to find out the association of hormonal status with the different grades of acne vulgaris female patients.. Methods: Fifty patients each of Mild (group I), Moderate (group II) and Severe Acne Vulgaris (group III) in age group 15-40 years were included as cases. The fasting blood samples were collected on the second day of menstrual cycle of the patient and before the start of treatment. Written and informed consent was taken from all subjects in the cases and control groups after explaining about the details of the study. Results: Levels of Luteinizing Hormone (LH), Estrogen, Testosterone, Insulin, Follicle Stimulating Hormone (FSH) and Prolactin in different grade of acne vulgaris patients were compared with control groups. Statistical analysis was done using Kruskal Wallis test and ANOVA. Conclusion: Level of LH, Estradiol,Testosterone andInsulin may be studied in cases resistant to conventional treatment of acne in women while the levels of FSH and prolactin, need not to be studied.

Correlation of Hormonal Profile and Lipid Levels with Late Onset Female Adult Acne

“…In this study, the levels of testosterone in the serum of the cases were significantly lower than the levels in the controls (P < 0.05). Other studies found that female acne vulgaris was significantly associated with elevated serum testosterone [10,16,21]. Each of these studies had a P-value of 0.05.…”

“…Comparing lipid profiles between the case and control groups, we did not find any statistically significant difference; however, Bakry et There was no substantial correlation between hormone levels and acne severity (P > 0.05). Serum testosterone levels were inversely correlated with DHEAS levels in three studies [14][15][16]. Acne severity was found to be inversely related to the lipid profile [3].…”

“…It was found that there was not a significant correlation between hormone levels and the severity of acne (P > 0.05). In three separate studies [14][15][16], researchers found that an inverse correlation existed between serum testosterone levels and DHEAS levels. According to the findings of Romańska-Gocka et al (2018), the severity of acne has an inverse relationship with the lipid profile [3].…”

Endocrine Disorders and Hormonal Therapy for Adolescent Acne

“…Corticotrophin-releasing hormone (CRH) and cortisol are hormones associated with tension which regulate sebaceous activity [62]. When acne-affected skin is compared to unaffected skin, extremely high levels of CRH expression are detected in the sebaceous glands [63].…”