A study of hypoglycemic effect of Caesalpinia bonduc extract on alloxan induced diabetic albino rats

Abstract

Background: The objective of the study was to scientifically investigate the oral hypoglycemic activity of Caesalpinia bonduc on Alloxan induced diabetic albino rats. To compare the hypoglycemic effect of Caesalpinia bonduc with that of the standard drug Glibenclamide used in the treatment of diabetes mellitus.Methods: Adult healthy albino rats of wister strain of either sex weighing 150-200gms were included in the study. The animals were divided into 4 groups namely control, diabetic control, standard and test groups with 6 animals in each group. Diabetes was chemically induced using alloxan to produce hyperglycemia in rats. Standard drug Glibenclamide suspended in gum acacia was administered for standard group. Test drug Caesalpinia bonduc was administered for test group. Morning around 9 a.m. blood glucose levels were recorded on 1st, 3rd, 7th, 14th, 21st, and 28th days.Results: The control group of rats showed no variation. The diabetic control rats showed consistent hyperglycemia. Comparing the test drug Caesalpinia bonduc to the standard drug Glibenclamide, the test drug was 1.38 times more efficacious than the standard.Conclusions: The alcoholic extract of Caesalpinia bonduc (seeds) has shown more anti diabetic activity by lowering the blood glucose levels in diabetic rats significantly. These findings suggest that hypoglycemic potential of the test compound Caesalpinia bonduc is promising and found to be more significant than the standard compound.

Effect of ethanolic seed extract of Caesalpinia bonducella on hormones in mifepristone induced PCOS rats

“…Oral administration of ESECB extract considerably reduced the levels of insulin and testosterone indicating the suppressive effect of insulin resistance. Previous studies by Nadaf et al (2017) and Ghosh et al (2012) have showed the hydro alcoholic extract has the potential of reducing blood glucose level. According to Shukla et al (2011), the phytoconstituents present in the C. bonducella considerably reduces the insulin resistance.…”

“…Administration of antiprogesterone Mifepristone RU486 (4 mg /0.2 ml oil) to 4 days estrous cyclic rats over eight consecutive days starting on the day of estrus (day 1) as per Sanchez-Criado et al (1993) method. To observe and monitor the development of PCOS condition in the rats, by irregular estrous cycle daily, vaginal smear test was conducted followed by the Mifepristone RU486 injection.…”

“…The major cause of the syndrome is infertility which was characterized by chronic anovulation hyperandrogenemia, altered luteinizing hormone (LH):follicle stimulating hormone (FSH) ratio and insulin resistance (Shannon, 2012). The insulin resistance has an important influence in the PCOS pathogenesis through the development of hyperinsulinemia, which leads to hyperandrogonism and further complications (Poretsky et al, 1999). Moreover, in PCOS women, as insulin resistance is the major cause of metabolic syndrome and cardiovascular diseases, the treatment strategies mainly involves the use of insulin sensitizing drugs and life style modifications (Spritzer, 2014).…”