A study of incidence of congenital anomalies in newborn: a hospital based study

Prashar, Nivedita; Gupta, Shashi; Thakur, Reeta; Sharma, Preeti; Sharma, Gopal

doi:10.18203/2320-6012.ijrms20161758

Cited by 9 publications

(16 citation statements)

References 4 publications

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“…In the current study, the incidence of congenital anomalies increased as the birth weight decreased and also increased with prematurity, which is statistically significant. This association of low birth weight and congenital defects has been demonstrated in other studies as well 5,6,7 . Association of birth defects with prematurity is well documented in previous studies 5,7 .…”

Section: Discussionsupporting

confidence: 79%

“…This association of low birth weight and congenital defects has been demonstrated in other studies as well 5,6,7 . Association of birth defects with prematurity is well documented in previous studies 5,7 . Although many studies have documented an association of birth defects with still birth, it was not apparent in our study 5,6 .…”

Section: Discussionsupporting

confidence: 79%

“…Our study demonstrates a higher incidence of birth defects compared to Indian studies which describe rates ranging from 1.2%-1.8% 5,6 . The observed higher rate could be due to increased referrals of mothers with an abnormal fetus to SJGH and high rate of identification.…”

Section: Discussioncontrasting

confidence: 49%

“…Association of birth defects with prematurity is well documented in previous studies 5,7 . Although many studies have documented an association of birth defects with still birth, it was not apparent in our study 5,6 . In previous studies male gender has been associated with increased incidence of birth defects 3,8 .…”

Section: Discussionmentioning

confidence: 54%

“…Commonest systems affected were central nervous system (49.6%), followed by urinary system (13.8%). They observed an association between parity and maternal age with the occurrence of congenital anomalies 5 . An incidence of 1.2% was described in another Indian study 6 .…”

Section: Introductionmentioning

confidence: 99%

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Prospective study on incidence and pattern of congenital abnormalities in a tertiary care hospital in Sri Lanka

Perera

Gamhewage

Weerasekera

2019

Sri Lanka J Child Health

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Background: Congenital abnormalities are defined as structural / functional abnormalities, and/or biochemical-molecular defects present at birth. Common grave anomalies are cardiac defects, neural tube defects and Down syndrome. Objectives: To assess incidence and type of congenital abnormalities in births at Sri Jayewardenepura General Hospital (SJGH). Method: A prospective study was done at SJGH from March 2015 to end of November 2017 including all the births during that time period. The information was recorded in a pretested data collection sheet. Data was analysed using SPSS statistical software. Results: Of 10,157 babies born during the study period (both live births and still births) the incidence of congenital abnormalities was 2.6%. Isolated congenital abnormalities were found in 137 (1.3%) babies and multiple congenital abnormalities were found in 96 (0.9%). Fifty one babies belonged to syndromes with an incidence of 0.5%. Mild, severe and lethal congenital anomalies had incidences of 1.4%, 1.2% and 0.1% respectively. The commonest anomalies were congenital heart diseases followed by muscular-skeletal system anomalies.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 79%

Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

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Prospective study on incidence and pattern of congenital abnormalities in a tertiary care hospital in Sri Lanka

Perera

Gamhewage

Weerasekera

2019

Sri Lanka J Child Health

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Prevalence and Association of Congenital Anomalies According to the Maternal Body Mass Index: Cross-Sectional Study

Moraes

Mendonça

Melo

et al. 2019

Rev Bras Ginecol Obstet

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Objective To evaluate and compare the prevalence of structural congenital anomalies (CAs) according to maternal body mass index (BMI). Methods The present cross-sectional study involved pregnant women with fetuses diagnosed with structural CAs through morphological ultrasonography between November 2014 and January 2016. The nutritional status of the pregnant women was classified according to the gross value of the body mass index. The pregnant women were categorized into four groups: low weight, adequate weight, overweight, and obesity. Statistical analysis was performed using Stata/SE version 12.0 (Stata Corporation, College Station, TX), with values of p 0.05 considered statistically significant. Results A total of 223 pregnant women had fetuses diagnosed with CAs. The prevalence of structural CAs in pregnant women with low weight was of 20.18%, of 43.50% in pregnant women with adequate weight, of 22.87% in pregnant women with overweight, and of 13.45% in pregnant women with obesity. The prevalence of central nervous system (CNS) anomalies and of genitourinary system anomalies was high for the four groups of pregnant women. A positive association was observed between multiple anomalies in pregnant women with adequate weight (prevalence ratio [PR] ¼ 1.65; p 0.004) and between anomalies of the lymphatic system in obese pregnant women (PR ¼ 4.04, p 0.000). Conclusion The prevalence of CNS and genitourinary system anomalies was high in all of the BMI categories. Obese pregnancies were associated with lymphatic system anomalies. Therefore, screening and identification of the risk factors for CAs are important, regardless of the maternal BMI. Our findings reinforce the importance of discussing with pregnant women maternal nutrition and its effect on fetal development and on neonatal outcome.Carolina Leão de Moraes's ORCID is https://orcid.org/0000-0003-0755-0753.

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Frequency of Congenital Anomalies in the Brazilian Midwest and the Association with Maternal Risk Factors: Case-control Study

Moraes

Melo

Amaral

2020

Rev Bras Ginecol Obstet

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Objective To evaluate the frequency of structural congenital anomalies (CAs) in the midwest of Brazil and its association with maternal risk factors. Methods This was a prospective, observational, case-control study based on a hospital population. Pregnant women attended at a fetal medicine service in Brazil were analyzed in the period from October 2014 to February 2016.A total of 357 pregnant women were included, 223 of whom had fetuses with structural anomalies (group case), and 134 of whom had structurally normal fetuses (control group). The clinical history was made previous to prenatal consultation, and the diagnosis of the structural CA was performed through ultrasound. Results A frequency of 64.27% (n = 223) of pregnant women with fetuses with structural anomalies was observed. The most frequent structural CAs were those of the central nervous system (30.94%), followed by anomalies of the genitourinary system (23.80%), and, finally, by multiple CAs (16.60%). The background of previous children with CAs (odds ratio [OR]: 3.85; p = 0.022), family history (OR: 6.03; p = < 0.001), and consanguinity between the progenitors (OR: 4.43; p = 0.034) influenced the occurrence of structural CA. Conclusion The most frequent CAs are those of the central nervous system, followed by those of the genitourinary system, and then multiple anomalies. The maternal risk factors that may have influenced the occurrence of structural CA were previous children with CA, family history, and consanguinity among the parents.

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A study of incidence of congenital anomalies in newborn: a hospital based study

Cited by 9 publications

References 4 publications

Prospective study on incidence and pattern of congenital abnormalities in a tertiary care hospital in Sri Lanka

Prospective study on incidence and pattern of congenital abnormalities in a tertiary care hospital in Sri Lanka

Prevalence and Association of Congenital Anomalies According to the Maternal Body Mass Index: Cross-Sectional Study

Frequency of Congenital Anomalies in the Brazilian Midwest and the Association with Maternal Risk Factors: Case-control Study

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