A Study of Intrathecal Chemotherapy In Bacterial Meningitis

Weinstein, Louis; Goldfield, Martin; Adamis, Dionysios

doi:10.1016/s0025-7125(16)34955-0

Cited by 27 publications

(3 citation statements)

References 30 publications

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“…This becomes particularly important if steroid treatment is started, as this is detrimental to a patient with active infection. The rash of chronic meningococcaemia is said to recur at intervals of 24 to 48 hours, 2 and this pattern was clearly seen in the patient described.…”

Section: Discussionmentioning

confidence: 75%

Meningococcal septicaemia presenting as erythema multiforme

Raman

1990

Int J Clinical Practice

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Section: Discussionmentioning

confidence: 75%

Meningococcal septicaemia presenting as erythema multiforme

Raman

1990

Int J Clinical Practice

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“…Excessive dosage and drug impurities in the early years led to serious reactions, and determined opponents such as Hoyne (1953) found more favour (e.g. Smith, 1956) than supporters (Weinstein, Goldfield, and Adamis, 1953;McKendrick, 1954). In one British series with generally good follow-up results (Lawson et al, 1965) intrathecal therapy was more often used initially and has its continued advocates (Lorber, 1974).…”

Section: Treatmentmentioning

confidence: 99%

Bacterial meningitis. Some aspects of diagnosis and treatment.

Hambleton¹,

Davies²

1975

Archives of Disease in Childhood

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“…The neurotoxic potential of penicillin has been appreciated for some time (8). The neurotoxicity of aminoglycoside antibiotics was first noted in early experiences with intrathecal streptomycin administration (18). Several fatalities were reported in patients who received large intrathecal doses.…”

mentioning

confidence: 99%

Effect of osmotic blood-brain barrier disruption on gentamicin penetration into the cerebrospinal fluid and brains of normal rabbits

Strausbaugh¹,

Brinker²

1983

Antimicrob Agents Chemother

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Rapid infusion of hyperosmolar solutions into the internal carotid artery transiently disrupts the blood-brain barrier, permitting entry of substances that are ordinarily excluded from the nervous system. This study compared gentamicin concentrations in the cerebrospinal fluid (CSF) and brain tissue of rabbits receiving intracarotid infusions of 2 molal mannitol with those in three groups of control animals. After catheter placement and intravenous gentamicin administration (20 mg/kg), rabbits received either 2 molal mannitol in the internal carotid artery, 2 molal mannitol intravenously, 0.9%o saline in the internal carotid artery, or 0.9%o saline intravenously. Mannitol and saline were administered in 8-ml bolus injections over 40 s. After 2 h, serum, CSF, and brain specimens were obtained for antibiotic assay, Gentamicin concentrations in serum were comparable in all groups (mean concentrations ranged from 14.6 to 17.9 ,ug/ml at 60 min and from 5.7 to 7.4 g/ml at 135 min), but gentamicin concentrations in CSF and brains were significantly higher in animals in the group receiving mannitol in the internal carotid artery. In this group the mean gentamicin concentration in CSF, 5.3 ,ug/ml, was twofold greater than those in the other three groups (range, 1.7 to 2.6 ,ug/ml). Similarly, the mean gentamicin concentration in the brains of animals in the group receiving mannitol in the internal carotid artery, 2.3 ,ug/g was significantly higher than those in the other groups (mean of measurable values, 1.4 pug/g, in all three control groups). Osmotic disruption of the blood-brain barrier enhanced the penetration of gentamicin into CSF and brain tissue.

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A Study of Intrathecal Chemotherapy In Bacterial Meningitis

Cited by 27 publications

References 30 publications

Meningococcal septicaemia presenting as erythema multiforme

Meningococcal septicaemia presenting as erythema multiforme

Bacterial meningitis. Some aspects of diagnosis and treatment.

Effect of osmotic blood-brain barrier disruption on gentamicin penetration into the cerebrospinal fluid and brains of normal rabbits

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