A study of Ki-67 expression and its clinicopathological determinants in nondysplastic oral leukoplakia

Mondal, Krishnendu; Mandal, Rajesh Kumar; Sarkar, Badal Chandra

doi:10.4103/0976-237x.194106

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…The mean value of LI was found to increase as the nature of the lesion changed especially from dysplasia to SCC. In the present study, normal oral epithelium expressed the lowest Ki-67 LI while the proliferative activity of non dyplastic leukoplakia was higher, similar to Mondal et al [20] however this was contrary to, Dwivedi et al [21] and Kumar et al [22] who noticed very little disagreement between the mean LIs of normal oral epithelium (13.65%) and nondysplastic OL (12.78%). In our study, the discrepant and relatively higher mean LIs within leukoplakia lacking any dysplasia are ~ 361 ~ possibly a consequence of smaller sample sizes.…”

Section: Discussionsupporting

confidence: 58%

Expression profile of apoptotic and proliferative markers in oral lesions and its clinicopathological significance

Jairajpuri¹,

Jetley²,

Rana³

et al. 2020

Int. J. Clin. Diagn. Pathol.

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Introduction: Oral cavity is prone to a myriad of changes with advancing age as well as a result of the environmental and life style related factors. Genetic abnormalities are the primary cause of dysplastic, metaplastic, and neoplastic changes resulting in an imbalance between molecular mechanisms which regulate apoptosis and cell proliferation. Evaluating these parameters may not only help in identifying the individuals who are at a greater risk of developing carcinomas, but also carry significant prognostic value. Aim: The present study was undertaken with the aim of evaluating the expression profile of Bcl2 and Ki-67 as biomarkers in assessing the apoptotic and proliferative activity of Oral lesions and compare the topographical aspect of these lesions. Material and Methods: A cross sectional study of 31cases of oral lesions, immunohistochemically assessed for Bcl-2 and Ki67 for their expression pattern. Results: Expression of Ki-67 showed a linear increase from normal oral epithelium through various histological grades of Oral squamous cell carcinoma (OSCC). Expression of Bcl-2 was variable, defined by cytoplasmic granular staining in the epithelial cells. A decrease in mean positivity was seen from well differentiated OSCC to Moderately differentiated OSCC. Weak intensity of Bcl2 staining was seen in all the cases except one case of poorly differentiated oral squamous cell carcinoma. Conclusion:The pattern of expression of biomarkers, not only help in diagnosing oral lesion but also in identifying prognostic markers. Alterations in the expression of proteins related to cell proliferation and apoptosis are a strong indicator of the malignant transformation potential of certain lesions.

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Section: Discussionsupporting

confidence: 58%

Expression profile of apoptotic and proliferative markers in oral lesions and its clinicopathological significance

Jairajpuri¹,

Jetley²,

Rana³

et al. 2020

Int. J. Clin. Diagn. Pathol.

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“…Ki-67 positivity was assessed using a scoring system proposed by Kannan. 22,23,24 The details of scoring interpretation are as follows: Score 0 = 0 -5% Score 2 = 6-25% Score 4 = 26 -60% Score 6 = 61 -99% 22 Statistical analysis was carried out using Statistical Package for Social Sciences version 19. Frequency and percentages were calculated for categorical variables, i.e., level of expression of Ki-67 in basal, parabasal and suprabasal layers of epithelium.…”

Section: Methodsmentioning

confidence: 99%

“…Several authors tried to correlate hyperkeratosis with OL but they did not associate it with the use of snuff. 24,26,30,31 Similarly. international literature regarding immunohistochemical expression of Ki-67 in snuff users in basal, parabasal and suprabasal layers for comparison with this study could not be found on extensive search.…”

Section: Ki-67 Positivity (Score) Basal Layer N(%) Parabasal Layer N(mentioning

confidence: 99%

Determination of Ki-67 expression in oral leukoplakia in snuff users and non-users in Khyber Pakhtunkhwa province of Pakistan.

Naushin

Khan

Ahmed

et al. 2020

TPMJ

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Objectives: The aim of the article was to evaluate Ki-67 expression in oral leukoplakia in snuff users and non-users. Study Design: Descriptive Cross sectional study. Setting: At different hospitals of Khyber Pakhtunkhwa province. Period: From August 2016 –March 2017. Material & Methods: Clinically diagnosed and histopathologically confirmed cases of oral leukoplakia in snuff users and non-users 30 cases each were immunohistochemically examined and percentage expression of nuclear Ki-67 was evaluated by a semi quantitative method in basal, parabasal and suprabasal layers of the lining epithelium. Results: The relationship of expression of Ki-67 in parabasal and suprabasal layers of affected epithelium in snuff users was found to be statistically significant with a p value of 0.007 and 0.002 respectively. Conclusion: The present study concludes that the proliferative index is high in snuff users as compared to non-users which can be a factor for malignant transformation.

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“…Although the significant roles played by oncogenes and tumor suppressor genes in the development of OSCC have been explored, there are few data on the pathogenesis of OSMF as well as of its MT at the molecular level. [ 8 , 9 ] Therefore, the early detection of potentially malignant OSMF has been crucial in the inhibition of oral cancer. Thus the present study aims to evaluate the demographic (age, education, and socioeconomic status) and pathological factors (habits with duration and frequency) for OSMF and degree and pattern of expression of p53 in OSMF, OSCC, and normal patients and to study the correlation between p53 expression with clinical staging and histological grading of OSMF.…”

Section: Introductionmentioning

confidence: 99%

Expression of p53 as Potential Biomarker in Oral Submucous Fibrosis: An Immunohistochemical Study

Kamala¹,

Kanetkar²,

Datkhile³

et al. 2023

Journal of Microscopy and Ultrastructure

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Background: Oral submucous fibrosis (OSMF) is potentially malignant disorder known to transform into oral cancer. The malignant transformation is often associated with changes at the genetic level that in turn is reflected by the altered expression of proteins related to cell cycle, proliferation, and apoptosis. Expression of p53 tumor suppressor gene is one of the common findings in human cancers including the oral cancer. Therefore, the early detection of potentially malignant OSMF has been crucial in the inhibition of oral cancer. Aim and Objectives: To determine the main pathological logical factors and expression of aberrant p53 in OSMF, oral squamous cell carcinomas (OSCC) and in normal patients, to study correlation between p53 expression with clinical staging and histological grading of OSMF. Materials and Methods: An immunohistochemical (IHC) study was performed for p53 expression on 35 cases of OSMF, 10 cases of OSCC with history of habits and 10 normal patients without any habits. Results: The expression of p53 showed a significant difference between normal oral mucosa, OSMF and OSCC samples. Conclusion: The study demonstrated a high incidence of p53 over expression in OSMF and OSCC. The results indicate that p53 over expression may play a role in pathogenesis of OSMF and in the development of Oral squamous cell carcinoma. With early detection of the high-risk patients with OSMF, we can expect to develop more intensive treatment modalities, leading to the reduction in cancer transformation rate from OSMF.

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A study of Ki-67 expression and its clinicopathological determinants in nondysplastic oral leukoplakia

Cited by 7 publications

References 25 publications

Expression profile of apoptotic and proliferative markers in oral lesions and its clinicopathological significance

Expression profile of apoptotic and proliferative markers in oral lesions and its clinicopathological significance

Determination of Ki-67 expression in oral leukoplakia in snuff users and non-users in Khyber Pakhtunkhwa province of Pakistan.

Expression of p53 as Potential Biomarker in Oral Submucous Fibrosis: An Immunohistochemical Study

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