A study of lipid profile in patients of subclinical hypothyroidism in rural area of Western Uttar Pradesh, India

Kumar, Manoj; Rajpoot, Raveendra S.

doi:10.18203/2320-6012.ijrms20162273

Cited by 2 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Verma et al 37 showed higher serum NO levels in hypothyroid individuals in India, which was similar to Atta et al 38 and Coria et al studies 39 conducted on hypothyroid cases, respectively. In contrast, other studies showed lower serum NO levels 40 or no nitrate changes in hypothyroid patients. 41…”

Section: 30mentioning

confidence: 71%

Association between serum vitamin B12, folic acid & nitrosative stress in hypothyroidism

Kureshi¹,

Aggarwal²,

Batra³

2023

View full text Add to dashboard Cite

Hypothyroidism may occur as a result of primary gland failure or insufficient thyroid gland stimulation by the hypothalamus or pituitary gland. Hypothyroidism may be associated with pernicious anemia as part of the autoimmune polyglandular endocrinopathy. Thyroid hormones (THs) influence endothelium and directly raise NO production in vascular smooth muscle cells through the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. Folic acid deficiency, administration of folate antagonists such as methotrexate and carbamazepine and disturbance of methionine metabolism after hypothyroidism has been suggested as the reasons of rising in serum homocysteine levels. The following article reviewed association of serum vitamin B12, folic acid and nitrosative stress in hypothyroidism. It suggests that combination therapy with levothyroxine plus folic acid will diminish serum homocysteine level more effectively; so this treatment regimen is preferable to levothyroxine alone in hypothyroidism.

show abstract

Section: 30mentioning

confidence: 71%

Association between serum vitamin B12, folic acid & nitrosative stress in hypothyroidism

Kureshi¹,

Aggarwal²,

Batra³

2023

View full text Add to dashboard Cite

show abstract

Lipid Profile in Thyroid Autoimmunity - A Study among Reproductive Age Group Females of Central Kerala

Surendranath¹,

Palakkaparambil²,

Thadathil³

et al. 2021

jemds

View full text Add to dashboard Cite

BACKGROUND One of the most common causes of thyroid dysfunction among women is autoimmunity, especially in fertile age group. Thyroid hormone disorders are associated with a number of biochemical abnormalities including dyslipidaemia, metabolic dysfunctions, spontaneous miscarriage, and preterm delivery. Dyslipidaemia is one of the most common metabolic abnormalities present in patients with thyroid disease. The purpose of this study was to find the association between anti-thyroid peroxidase antibody (anti-TPO) and dyslipidaemia in reproductive age group females from Central Kerala. METHODS A total of 200 asymptomatic women, all in reproductive age group, from a tertiary hospital in Kerala participated in this study. Demographic data and detailed medical history of the participants were collected. Anti-TPO and thyroid stimulating hormone (TSH) were measured using chemiluminescence immunoassay system. Serum lipid profile was estimated using fully automated random-access clinical chemistry analyser EM - 360. Continuous variables were compared between the groups using Mann–Whitney U-test. P value lesser than 0.05 was considered as statistically significant. RESULTS The mean age of the subjects was 32.92 ± 11.82 years. A total of 47 participants (23.5 %) were anti-TPO positive. Abnormality in lipid profile was present in 72.34 % (N = 34) of the anti-TPO positive participants. In the anti-TPO positive group, 51.06 % of the participants had hypercholesterolemia. In the anti-TPO positive group, anti-TPO levels show a statistically significant correlation with total cholesterol and triglyceride levels (P = 0.07 and P < 0.01). A total of 9 % (N = 18) had thyroid stimulating hormone (TSH) values greater than normal range (0.34- 4.25 µIU/mL) suggesting presence of hypothyroidism. TSH values were also significantly associated with lipid profile in the anti-TPO positive group. Both thyroid autoimmunity and dyslipidaemia can affect fertility, pregnancy and other reproductive outcomes. CONCLUSIONS Women should be screened for autoimmune antibodies and associated biochemical abnormalities to estimate and reduce the risk of cardiovascular morbidity, negative pregnancy outcomes and infertility. KEY WORDS Thyroid Autoimmunity, Anti-TPO Antibody, Dyslipidaemia

show abstract

A study of lipid profile in patients of subclinical hypothyroidism in rural area of Western Uttar Pradesh, India

Cited by 2 publications

References 19 publications

Association between serum vitamin B12, folic acid & nitrosative stress in hypothyroidism

Association between serum vitamin B12, folic acid & nitrosative stress in hypothyroidism

Lipid Profile in Thyroid Autoimmunity - A Study among Reproductive Age Group Females of Central Kerala

Contact Info

Product

Resources

About