Magnetohydrodynamics (MHD) is becoming more popular every day among developers of applications based on microfluidics, such as “lab on a chip” (LOC) and/or “micro-total analysis systems” (micro-TAS). Its physical properties enable fluid manipulation for tasks such as pumping, networking, propelling, stirring, mixing, and even cooling without the need for mechanical components, and its non-intrusive nature provides a solution to mechanical systems issues. However, these are not easy tasks. They all require precise flow control, which depends on several parameters, like microfluidics conductivity, the microfluidics conduit (channel) shape and size configuration, and the interaction between magnetic and electric fields. This results in a mathematical model that needs to be validated theoretically and experimentally. The present paper introduces the design of a 3D laminar flow involving an electrolyte in an annular open channel driven by a Lorentz force. For an organized description, first of all is provided an introduction to MHD applied in microfluidics, then an overall description of the proposed MHD microfluidic system is given, after that is focused in the theoretical validation of the mathematical model, next is described the experimental validation of the mathematical model using a customized vision system, and finally conclusions and future work are stated.