A study of predictive value of microalbuminuria in early outcome of non-diabetic patients of acute myocardial infarction

Patel, Saurabh; Acharya, Harshit; Saiyad, Mubassir

doi:10.18203/2349-3933.ijam20170523

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…The overall prevalence of micro-albuminuria in non-diabetic ACS in this study was 73% which was statistically significant (p=0.04). The studies done outside also show similar findings ranging from 58-92% [6][7][8][9][10] . In the study done by F Aziz et al found prevalence of MA to be 56.5% in angiographically proved severe CAD (luminal narrowing > 70%) 11 , Similarly, in the study done by Silva et al on prevalence of MA in 39 patients with angiographically confirmed severe lesion (stenosis > 70%) in at least one coronary artery found to be 33% which was statistically significant 12 .…”

Section: Discussionsupporting

confidence: 66%

Profile of Non-Diabetic patients with Microalbuminuria in Acute Coronary Syndrome: A hospital based study

et al. 2019

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Background and Aims: Microalbuminuria (MA) (urinary albumin excretion of 30-299 mg/d in a 24 hours collection or 30-299 μg/mg creatinine in a spot collection) is well accepted marker of micro and macrovascular damage in patients with diabetes mellitus and is considered as a surrogate marker for endothelial dysfunction in diabetic and non-diabetic patients. This study has been undertaken to investigate the prevalence of microalbuminuria among non-diabetic Acute Coronary Syndrome (ACS) patients. Methods: A hospital based cross-sectional study of 100 consecutive non-diabetic ACS patients was done. Traditional risk factors (like smoking, hypertension, dyslipidemia, obesity) of coronary artery disease were studied for the association with microalbuminuria in study subjects. Investigations were carried out in all the cases as per proforma and entered in the SPSS software for analysis. Results: The prevalence of microalbuminuria in non-diabetic ACS patients in the study was 73% which was statistically significant (p=0.04). A statistically significant higher prevalence of microalbuminuria was seen with different presentations of ACS; being highest (81.96%) in NSTEMI followed by STEMI (63.15%) and Unstable Angina (55%). It was found to be significant with the history of smoking (81.25%, p=0.013) and hypertension (82.25%, p=0.013). No significant association was found with age, body mass index (BMI) and dyslipidemia. A statistically significant higher prevalence of microalbuminuria was seen with increasing number of risk factors. Conclusion: There is increased prevalence of microalbuminuria in ACS patents. MA was associated with statistically higher number of cases with history of smoking and hypertension and presence of increasing number of risk factors.

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Section: Discussionsupporting

confidence: 66%

Profile of Non-Diabetic patients with Microalbuminuria in Acute Coronary Syndrome: A hospital based study

et al. 2019

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Section: Discussionsupporting

confidence: 66%

“…For current analysis, aspirin dose less than 200 mg was defined as low dose and more than 200 was defined as high dose. This cutoff point was based on similar previous landmark studies [8][9][10] . All the patients who had undergone PCI at our hospital from 2017 February to October 2017 were enrolled in the study.…”

Section: Methodsmentioning

confidence: 99%

High dose versus low dose Aspirin after Percutaneous Coronary Intervention in Coronary Artery Disease

et al. 2019

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Background and Aims: Patients with Coronary artery disease who undergo percutaneous coronary intervention (PCI) are prescribed with maintenance aspirin dose that vary between 75 mg to 300 mg daily. The objective of this study is to evaluate the effects of high dose versus low dose aspirin doses prescribed on hospital discharge in PCI. Methods: All the patients who had undergone PCI at our hospital from 2017 February to October 2017 were enrolled in the study. They were divided into two groups receiving low dose (<200mg) aspirin and high dose (>200mg) aspirin. Patients were interviewed on phone after completion of one year for the possible complications and new ischemic events during the follow up period. Results: Among 150 patients selected 101 fulfilled the criteria and sixty patients (59.4%) were discharged on low-dose aspirin 75-150mg and 41 patients (40.6%) were discharged on high-dose aspirin of 300mg. The mean age in low aspirin group was 59.8±13.19 years and 49.4±10.7 years in high aspirin group. Although high aspirin dose patients did not complain of epigastric pain more often, upper GI bleeding was significantly higher in high aspirin group 7.5% vs 11.1% (p<0.05). One patient in high aspirin group had hemorrhagic stroke while low aspirin group had none. One patient in high aspirin had sudden cardiac death at home. Clinically, there was no significant difference in new ischemic events during follow up period. Conclusion: In patients with coronary artery disease undergoing PCI, discharge on high-dose rather than low-dose aspirin may increase the rate of bleeding without providing additional ischemic benefit.

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A study of predictive value of microalbuminuria in early outcome of non-diabetic patients of acute myocardial infarction

Cited by 2 publications

References 6 publications

Profile of Non-Diabetic patients with Microalbuminuria in Acute Coronary Syndrome: A hospital based study

Profile of Non-Diabetic patients with Microalbuminuria in Acute Coronary Syndrome: A hospital based study

High dose versus low dose Aspirin after Percutaneous Coronary Intervention in Coronary Artery Disease

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