A Study of Pretreatment Nomograms to Predict Pathological Stage and Biochemical Recurrence After Radical Prostatectomy for Clinically Resectable Prostate Cancer in Japanese Men

Egawa, Shin; Suyama, Kimita; Arai, Yoichi; Matsumoto, Kazumasa; Tsukayama, Chotatsu; Kuwao, Sadahito; Baba, Shirō

doi:10.1093/jjco/hye018

Cited by 25 publications

(16 citation statements)

References 16 publications

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“…In their cohort, positive SM was significantly predicting a higher rate of BCR, although they did not directly examine the association between the clinical stage and the BCR. In a study on Japanese populations, Egawa et al found that clinical stage contributed significantly in the prediction of biochemical recurrence, in their cohort of patients [21]. …”

Section: Preoperative Factorsmentioning

confidence: 99%

Prognostic Factors for the Development of Biochemical Recurrence after Radical Prostatectomy

Kotb

Elabbady

2011

Prostate Cancer

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Prostate cancer is one of the most common cancers in Western countries and is associated with a considerable risk of mortality. Biochemical recurrence following radical prostatectomy is a relatively common finding, affecting approximately 25% of cases. The aim of our paper was to identify factors that can predict the occurrence of biochemical recurrence, so the patient can be properly counselled pre- and postoperatively. Medline review of the literatures was done followed by a group discussion on the chosen publications and their valuable influence. Preoperative serum total PSA and clinical stage, together with prostatectomy Gleason grade, tumour volume, and perineural and vascular invasions, were the most important variables found to influence outcome.

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Section: Preoperative Factorsmentioning

confidence: 99%

Prognostic Factors for the Development of Biochemical Recurrence after Radical Prostatectomy

Kotb

Elabbady

2011

Prostate Cancer

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“…For this reason, many authors have analyzed the use of pre-and postoperative nomograms in order to find patients in which a high risk of extra-prostatic disease (15) or high rates of disease progression are expected (16,17).…”

Section: Introductionmentioning

confidence: 99%

A new nomogram to predict pathologic outcome following radical prostatectomy

et al. 2006

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Objective: To develop a preoperative nomogram to predict pathologic outcome in patients submitted to radical prostatectomy for clinical localized prostate cancer. Materials and Methods: Nine hundred and sixty patients with clinical stage T1 and T2 prostate cancer were evaluated following radical prostatectomy, and 898 were included in the study. Following a multivariate analysis, nomograms were developed incorporating serum PSA, biopsy Gleason score, and percentage of positive biopsy cores in order to predict the risks of extraprostatic tumor extension, and seminal vesicle involvement. Results: In univariate analysis there was a significant association between percentage of positive biopsy cores (p < 0.001), serum PSA (p = 0.001) and biopsy Gleason score (p < 0.001) with extraprostatic tumor extension. A similar pathologic outcome was seen among tumors with Gleason score 7, and Gleason score 8 to 10. In multivariate analysis, the 3 preoperative variables showed independent significance to predict tumor extension. This allowed the development of nomogram-1 (using Gleason scores in 3 categories -2 to 6, 7 and 8 to 10) and nomogram-2 (using Gleason scores in 2 categories -2 to 6 and 7 to 10) to predict disease extension based on these 3 parameters. In the validation analysis, 87% and 91.1% of the time the nomograms-1 and 2, correctly predicted the probability of a pathological stage to within 10% respectively. Conclusion: Incorporating percent of positive biopsy cores to a nomogram that includes preoperative serum PSA and biopsy Gleason score, can accurately predict the presence of extraprostatic disease extension in patients with clinical localized prostate cancer.

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“…Using serum prostate-specific antigen (PSA), biopsy Gleason score and clinical stage, as well as a variety of other clinical variables and their combinations, pretreatment nomograms have been constructed for the prognosis of these tumors (1-9). Although these nomograms have aided clinicians in counseling patients and selecting optimal treatment methods, the validity and general applicability of these tables have been questioned, especially in regard to their extrapolation to populations and groups other than those in which the nomograms were originally constructed (4, 10, 11). …”

Section: Introductionmentioning

confidence: 99%

Nomograms for the Prediction of Pathologic Stage of Clinically Localized Prostate Cancer in Korean Men

Song

Kang

et al. 2005

J Korean Med Sci

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We analyzed the prostate cancer data of 317 Korean men with clinically localized prostate cancer who underwent radical prostatectomy at Asan Medical Center between June 1990 and November 2003 to construct nomograms predicting the pathologic stage of these tumors, and compared the outcome with preexisting nomograms. Multinomial log-linear regression was performed for the simultaneous prediction of organ-confined disease (OCD), extracapsular extension (ECE), seminal vesicle invasion (SVI) and lymph node metastasis (LNM) using serum prostate-specific antigen (PSA), Gleason score and clinical stage. Nomograms representing percent probabilities were constructed and compared with those presented by Partin et al. by calculating areas under the receiver operating characteristics (ROC) curves. Median serum PSA at surgery was 10.8 ng/mL, and median biopsy Gleason score was 7. Overall OCD, ECE, SVI and LNM rates were 59.6%, 20.5%, 11.7% and 8.2%, respectively, and areas under the curves were 0.724, 0.626, 0.662, and 0.794, respectively. Pathologic stage of localized prostate cancer in Korean men may be predicted using the Partin table, with acceptable accuracy for OCD and LNM, but less so for ECE and SVI.

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A Study of Pretreatment Nomograms to Predict Pathological Stage and Biochemical Recurrence After Radical Prostatectomy for Clinically Resectable Prostate Cancer in Japanese Men

Cited by 25 publications

References 16 publications

Prognostic Factors for the Development of Biochemical Recurrence after Radical Prostatectomy

Prognostic Factors for the Development of Biochemical Recurrence after Radical Prostatectomy

A new nomogram to predict pathologic outcome following radical prostatectomy

Nomograms for the Prediction of Pathologic Stage of Clinically Localized Prostate Cancer in Korean Men

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