A study of risk factors for hypospadias in the Rhône-Alpes region (France)

Morera, A.M.; Valmalle, A.F.; Asensio, M.J.; Chossegros, Laetitia; CHAUVIN, Marie-France; Durand, Philippe; Mouriquand, Pierre

doi:10.1016/j.jpurol.2005.09.008

Cited by 34 publications

(23 citation statements)

References 31 publications

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“…Viral infection during pregnancy has also been associated with hypospadias,1119 including in carriers of hepatitis B antigen11 and in women who had experienced a viral infection or influenza during the first trimester of pregnancy 19. Similarly, we found that the incidence of infection differed significantly in our case and control groups.…”

Section: Discussionsupporting

confidence: 64%

Risk factors for hypospadias in China

Liang

Lipianskaya

et al. 2014

Asian J Androl

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This case-controlled study was designed to evaluate the association between various baseline parental factors and the risk of hypospadias in China. Patients were selected from tertiary referral hospitals in Anhui, a province in mid-eastern China. A questionnaire was given to the parents of each patient. The final database included 193 cases and 835 controls. The incidence of additional coexistent anomalies was 13.0%, primarily cryptorchidism (9.8%). Ten patients (5.1%) were from families with genital anomaly, including five families (2.6%) with hypospadias. The risks of hypospadias was higher for children of mothers > 35 (odds ratio [OR] =1.47) and < 18 (OR = 2.95) years of age, and in mothers who had consumed alcohol (OR = 2.67), used drugs (OR = 1.53) and had an infection (OR = 1.87) during pregnancy. The risk of hypospadias was also higher when mothers (OR = 1.68) and fathers (OR = 1.74) were engaged in agriculture. Other factors assessed were not associated with the risk of hypospadias.

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Section: Discussionsupporting

confidence: 64%

Risk factors for hypospadias in China

Liang

Lipianskaya

et al. 2014

Asian J Androl

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“…The following studies have also observed positive associations between first birth and specific birth defects: hypospadias (Chen and Woolley, 1971;Akre et al, 1999;Weidner et al, 1999;Carmichael et al, 2003;Aschim et al, 2004;Meyer et al, 2006;Morera et al, 2006;van Rooij et al, 2013), esophageal atresia (Oddsberg et al, 2008), gastroschisis (Vu et al, 2008;Benjamin et al, 2010;Doung et al, 2012), spina bifida (Elwood et al, 1979;Evans, 1979), diaphragmatic hernia (Yang et al, 2006), craniosynostosis (Sanchez-Lara et al, 2010), omphalocele (Agopian et al, 2009), and talipes equinovarus/clubfoot (Alderman et al, 1988;Moorthi et al, 2005).…”

Section: Discussionmentioning

confidence: 96%

The association between maternal parity and birth defects

McNeese

Selwyn

Duong³

et al. 2015

Birth Defects Research

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“…The hormonal pro-estrogenic stimulation may be a risk factor by itself. 104 Fathers of hypospadiac boys have a lower sperm concentration and more frequent morphologic abnormalities, thus requiring ART. 105 A long time between the first attempt and pregnancy is also a risk factor for hypospadias.…”

Section: Assisted Reproductive Techniques and Hypospadiasmentioning

confidence: 99%

Molecular genetics of hypospadias and cryptorchidism recent developments

et al. 2018

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During the last decade, a tremendous amount of work has been devoted to the study of the molecular genetics of isolated hypospadias and cryptorchidism, two minor forms of disorders of sex development (DSD). Beyond the genes involved in gonadal determination and sex differentiation, including those underlying androgen biosynthesis and signaling, new genes have been identified through genome-wide association study and familial clustering. Even if no single genetic defect can explain the whole spectrum of DSD, these recent studies reinforce the strong role of the genetic background in the occurrence of these defects. The timing of signaling disruption may explain the different phenotypes.

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A study of risk factors for hypospadias in the Rhône-Alpes region (France)

Cited by 34 publications

References 31 publications

Risk factors for hypospadias in China

Risk factors for hypospadias in China

The association between maternal parity and birth defects

Molecular genetics of hypospadias and cryptorchidism recent developments

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