A study of selective spectrophotometric methods for simultaneous determination of Itopride hydrochloride and Rabeprazole sodium binary mixture: Resolving sever overlapping spectra

Current Trends in Simultaneous Determination of Co-Administered Drugs

“…In this case, the use of spectrofluorimetric techniques is often adopted, and no interfering signals due co-formulated drugs are present, as recently reported by Walash et al [10]. In the same way, derivative spectrophotometric procedures also allow analyses of pharmaceutical formulations, as reported for the simultaneous determination of co-formulated binary mixtures for specific treatments [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. In this case, the main problem is related to the possibility of resolving the overlapping peaks phenomena that occurs in a "cumulative" absorbance measure when different signals are recorded.…”

Novel Upcoming Therapies

“…This compound contains a fixed-dose combination of rabeprazole 20 mg and itopride 150 mg [41,42]. The efficacy and safety of this drug has been evaluated in patients with functional dyspepsia and NERD [43].…”

Greenness-sustainability metrics for assessment smart-chemometric spectrophotometric strategy for evaluation of the combination of six gastric proton-pump inhibitors with two selected impurities

“…Additionally, UPLC, UPLC–MS/MS [25] , [26] , [27] , LC-MS/MS, and LC-DAD techniques were applied [28] , [29] , [30] . Several reports also highlight eco-friendly approaches such as derivative analysis, ratio spectra, and mathematical modeling in both binary and ternary mixtures with other drugs [31] , [32] , [33] . On the other hand, none of these methods possesses the capability to determine OME, ESO, LAN, PAN, RAB, and DEX along with two selected official impurities,4-DES-Imp., and RAB-Imp.…”