A Study of Selenium in Leprosy

Partogi, Donna; Dalimunthe, Dina Arwina; Hazlianda, Cut Putri

doi:10.3889/oamjms.2018.136

Cited by 5 publications

(6 citation statements)

References 10 publications

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“…The key role of selenium in human metabolism is attributed to its presence in the glutathione peroxidase, which protects cells against harmful effects of free radicals [27].…”

Section: Discussionmentioning

confidence: 99%

Serum level of Selenium, Zinc, and Vitamin C and their relation to the clinical spectrum of leprosy

Khalid

Mostafa

Attia

et al. 2022

J Infect Dev Ctries

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Introduction: Leprosy is a chronic infectious disease with many risk factors including inadequate nutrient intake and nutritional deficiencies, which affect the immune system, and influence leprosy progression. Objectives: To elucidate the relation between the serum level of zinc, vitamin C, and selenium and the clinical spectrum of leprosy. Methodology: A case control study included 100 leprotic patients (50 multibacillary and 50 paucibacillary) and 100 age and sex matched controls. Vitamin C was measured by ELISA, zinc was measured by using centronic colorimetric spectrophotometry, and selenium was measured by Inductivity Coupled Plasma Optical Emission Spectroscopy technique. Results: Zinc and Vitamin C levels were significantly lower in paucibacillary (mean ± SD = 89.86 ± 20.712 and 2.52 ± 1.27 respectively) and multibacillary (mean ± SD = 81.41 ± 18.61 and 1.98 ± 0.59 respectively) than in controls (mean ± SD = 107.34 ± 3.98 and 4.95 ± 2.45 respectively) (p value < 0.001) with no significant difference between paucibacillary and multibacillary patients (p value = 0.142 and = 0.066 respectively). Selenium level showed no significant difference between the three groups (p value > 0.05) (mean ± SD = 51.27 ± 42.61 in paucibacillary, 47.54 ± 30.21 in multibacillary, and 44.07 ± 46.58 in controls). Conclusions: Lower serum levels of zinc and vitamin C in leprosy patients may be a result of disease pathogenesis or related to the antioxidants based treatment. It might also present prior to the disease onset due to malnutrition that may have accelerated the development of leprosy.

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“…The key role of selenium in human metabolism is attributed to its presence in the glutathione peroxidase, which protects cells against harmful effects of free radicals [27].…”

Section: Discussionmentioning

confidence: 99%

Serum level of Selenium, Zinc, and Vitamin C and their relation to the clinical spectrum of leprosy

Khalid

Mostafa

Attia

et al. 2022

J Infect Dev Ctries

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“…10 Selenium bekerja dengan cara aktivasi glutation peroksidase yang mengkatalisis reduksi hydrogen peroksidase dan hidroperoksida organik dan melindungi lemak dari kerusakan oksidatif. 7,11 Sebuah penelitian menyebutkan bahwa kadar selenium pada pasien kusta PB lebih tinggi daripada pasien kusta MB, dengan catatan jika indeks bakteriologi yang semakin tinggi maka kadar serum selenium akan semakin rendah. 1)PubMed: "leprosy" AND "vitamin D" dan "leprosy" AND "selenium"; 2)ResearchGate: "leprosy" AND "vitamin D" dan "leprosy" AND "selenium"; 3)DOAJ : "leprosy" AND "bacterial index", "leprosy" AND "micronutrient", "vitamin D" AND "mycobacterium leprae".…”

Section: Latar Belakangunclassified

“…Selenium berperan penting pada sistem kekebalan tubuh dan perlindungan terhadap radikal bebas dengan cara mengaktivasi enzim Glutathione Peroxidase (GPx).7 Kemudian GPx ini mengkatalisis reduksi hydrogen peroxidase dan hydroperoxida organic yang dapat melindungi lemak dari kerusakan oksidatif dengan bereaksi pada komponen seluler atau sistem imun seluler. 11,18 Pada sistem imun seluler dan humoral, selenium mampu mengatur tingkat interleukin, sehingga mempengaruhi kerentanan terhadap infeksi bakteri. 10…”

Section: B Mekanisme Selenium Terhadap Indeks Bakteriologiunclassified

“…Asupan Selenium dengan Indeks Bakteriologi Selenium berperan sebagai elemen yang mempengaruhi sistem kekebalan seluler dan humoral, dimana ketika terjadi defisiensi selenium maka dapat menyebabkan respon host yang tidak adekuat terhadap patogen infeksius. 11 Senyawa selenium yang paling utama diambil sebagai selenomethionine, lalu selenium methylselenocysteine atau gglutamyl-selenium-methylselenocysteine dari sayuran dan sebagai selenocysteine dari daging. 10 Kemudian senyawa selenium organik terbaru yakni selenoneine, ditemukan pada ikan laut (seperti tuna, mackerel).…”

Section: Hubunganunclassified

“…19 Secara signifikan terdapat korelasi negatif antara level serum selenium dengan indeks bakteriologi pasien penderita kusta MB (r = -0,499; p<0,005). 11 Hal ini dapat menjadi acuan bahwa asupan selenium memiliki hubungan dengan indeks bakteriologi, dimana ketika asupan selenium semakin tinggi maka level serum selenium juga semakin tinggi, sehingga indeks bakteriologi akan semakin rendah.…”

Section: Hubunganunclassified

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Hubungan Asupan Vitamin D Dan Selenium Dengan Indeks Bakteriologi Penderita Kusta Tipe MB (Multibacillary) : Systematic Literature Review

Putri

Yusyifak

Kardina

2021

JIM

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Background : As one of the infectious diseases that have a high prevalence until now, leprosy is a chronic transmission disease caused by infection with Mycobacterium Leprae. Apart from the standard MDT (Multidrug Therapy), nutritional support is a crucial component to restrict further infection severity. Vitamin D and selenium play essential roles as the primary defence against susceptibility. Methods : The systematic literature review was conducted using three international databases : PubMed, ResearchGate, and DOAJ, which were published between 2010 – 2020 using English or Indonesian. A total of 8 articles (2 articles identifying the correlation of selenium with leprosy, and 6 articles identifying the correlation of vitamin D with leprosy) using cross- sectional analytic and case-control analytic studies were included in this review. Results : The average serum levels of vitamin D and selenium in leprosy patients were lower than in healthy controls. This case was also found in Multibacillary leprosy patients compared to Paucibacillary leprosy patients. This serum levels can affect the bacteriological index, which is the higher the serum levels, the lower the bacteriological index. Disscusion : Serum vitamin D and selenium levels are affected by vitamin D and selenium intake, which can lead to a reduction in bacteriological index across all multibacillary leprosy patients. There is a negative correlation between vitamin D, selenium, and bacteriological index in patients with MB (Multibacillary) leprosy.Keywords:Leprosy, Vitamin D, Selenium, Bacteriological Index

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Oxidative Stress and Antioxidant Supplementation on Immunity in Hansen’s Disease (Leprosy)

Ferrari

2019

Oxidative Stress in Microbial Diseases

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A Study of Selenium in Leprosy

Cited by 5 publications

References 10 publications

Serum level of Selenium, Zinc, and Vitamin C and their relation to the clinical spectrum of leprosy

Serum level of Selenium, Zinc, and Vitamin C and their relation to the clinical spectrum of leprosy

Hubungan Asupan Vitamin D Dan Selenium Dengan Indeks Bakteriologi Penderita Kusta Tipe MB (Multibacillary) : Systematic Literature Review

Oxidative Stress and Antioxidant Supplementation on Immunity in Hansen’s Disease (Leprosy)

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