A study of serum levels of B cell-attracting chemokine-13 (CXCL 13) and rheumatologic manifestations of chronic hepatitis C virus infection in a cohort of Egyptian patients

Elattar, Enas A.; Younes, Takwa B.; abdo, Samia; Riad, George S.

doi:10.1016/j.ajme.2013.03.006

Cited by 1 publication

(2 citation statements)

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“…In contrast, El-Attar et al [28] studied 40 HCV patients and documented arthralgia in 65% of their patients, this high percentage may be explained by the small number of the study and arthralgia is considered a symptom rather than sign. In our study, arthritis was present in 5.1% with symmetric polyarthritis affecting the small joints of the hands and wrists in 80% of those patients while waxing and waning oligoarthritis was found in 20%.…”

Section: Discussionmentioning

confidence: 90%

“…Patients infected with HCV might develop at least one extrahepatic manifestation in 40-74% of cases during the course of the disease [26] , rheumatologic manifestations are among the most frequent. Many rheumatologic manifestations associated with HCV infection include arthralgia, myalgia, arthritis, vasculitis, sicca symptoms, mixed cryoglobulinemia (MC), and fibromyalgia [27,28] . Hand manifestations in the form of arthralgia and arthritis are the main extrahepatic manifestations in patients with HCV affecting mainly the metacarpophalangeal joints, wrists and proximal interphalangeal joints [29] .…”

Section: Discussionmentioning

confidence: 99%

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The Significance of Articular Hand Manifestations in Chronic HCV Patients

Bassiony

Dahan

Zaky

et al. 2014

Journal of Gastroenterology and Hepatology Research

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Aim:To evaluate the significance of rheumatic hand manifestations in chronic HCV patients. methods: Two hundred and ninety seven HCV patients were subjected to history taking, clinical examination, laboratory investigations including erythrocytic sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), antinuclear antibody (ANA) and anti-cyclic citrullinated peptide (Anti-CCP) and plain X-ray for hands and wrists. Results: The range of patients' age was 18-82 years (43.97±13.56). Their disease duration ranged from 6 months to 25 years (7.3+5.6).Hand affection was present in 137 patients (46.1%). The most frequent hand manifestations were arthralgia (28.6%), tenosynovitis (10.1%), Raynaud's phenomenon (9.1%), and arthritis (5.1%), while laboratory abnormalities were RF in (38.4%), ANA in (6.4%), cryoglobulins in (9.4%) and Anti-CCP in (1.3%). Female gender was the most important risk factors for hand manifestations. The patterns of arthritis in chronic HCV patients were non deforming polyarticular arthritis that affected the small joints of the hands and oligoarthritis. ConClusion: Our study strongly supports a direct role of HCV in inducing rheumatic hand manifestations and autoantibodies in chronic HCV patients, but it is mostly non-deforming and nonsignificant. Surveillance is needed for the detection of rheumatic manifestations and autoantibodies with occasional multidisciplinary team (hepatologist and rheumatologist) approach to HCV patients for early diagnosis and treatment. A long term follow up study for rheumatological manifestations in HCV patients is recommended to reduce health disparities.

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Section: Discussionmentioning

confidence: 90%