A Study of the Association Between IL-17 and HOMA-IR in Iraqi Type 2 Diabetic Patients

Abbas, Khetam M.; Alaaraji, Shakir F. T.; Alâ€“Shawk, Refif Sabih

doi:10.24996/ijs.2020.61.3.4

Cited by 13 publications

(11 citation statements)

References 26 publications

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“…Insulin resistance factors, HOMA-IR, HbA1C, and FBG were all significantly increased and showed positive correlation with UII increase, while QUICKI-IS showed a high significant but negative correlation with UII (r= -0.528 p= 0.0001). These results suggest UII tendencies to impair Bcell functions through fluctuations and disturbances of insulin regulation via the six pathways that were mentioned earlier in our discussion [43,44]. Interestingly, UII showed a synergistically significant increase with the increase in ET-I levels, which is another potent vasoconstrictor that has a major role in diabetic complications.…”

Section: Discussionsupporting

confidence: 68%

Association of Serum Urotensin-II Levels with Insulin Resistance and Endothelin-I in Type-II Diabetes Mellitus Patients

Khidhir

Mahmud

Maulood

2021

eijs

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Urotensin-II (UII), a pluripotent vasoactive cyclic peptide, exhibits the progression of cardiovascular diseases and the glucose metabolic disorder of insulin resistance. Type 2 Diabetes Mellitus (T2DM) is entirely associated with insulin resistance. This study aimed to demonstrate the association of UII with insulin resistance in diabetic and non-diabetic subjects. A total of 73 male and female subjects aged 40-60 years were recruited in this case-control study. They included 35 non- diabetic subjects with a body mass index of (BMI) ≤ 25 and 38 patients with Diabetes Mellitus and BMI ≥ 25. UII levels were assessed beside other vasoactive and clinical parameters. The results revealed that patients with T2DM had elevated UII and Endothelin-I (ET-I) levels, along with positive correlations with the insulin-resistance marker of Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), blood pressure (BP), fasting blood glucose (FBG), hemoglobin A1c (HbA1C), and asymmetric dimethylarginine (ADMA). Results from stepwise multiple regressions indicated that UII correlated positively with the increases in the levels of serum cholesterol, ET-I, urea, ADMA, and FBG. This study concludes that the increase in UII level has a positive relation with insulin-resistance and the increase in ET-I level. However, UII could inhibit glucose-induced insulin secretion and, hence, can be utilized as a marker for T2DM and its complications through inflammatory microangiopathy.

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Section: Discussionsupporting

confidence: 68%

Association of Serum Urotensin-II Levels with Insulin Resistance and Endothelin-I in Type-II Diabetes Mellitus Patients

Khidhir

Mahmud

Maulood

2021

eijs

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“…In fact, many chronic inflammatory disorders such as rheumatoid arthritis, psoriasis, and MS are associated with high IL-17A levels but, according to the current best knowledge, variations in IL-17 were not previously reported, which could be important for the various phases of the disease and its heterogeneity [26]. Another study that detected the relationship between IL-17 and insulin resistance found a crucial role of IL-17 in autoimmune disease [27].…”

Section: Interleukin-17amentioning

confidence: 95%

Impact of EBV on Multiple in a Sample of Iraqi Females: Immunological and Molecular Study

Kareem

Salman

2020

eijs

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This study was designed to highlight the role of Epstein Barr viruses (EBV) as a possible causative effect in multiple sclerosis (MS) through testing the viral load along with both biochemical and immunological parameters in female MS patients. We also aimed at finding the effects of different types of treatment line on the various study aspects. The results of the enzyme-linked immunosorbent assay (ELISA) revealed first an increased level of EBV EBNA1IgG IL-17A (96.13±27.60 pg/ml) in sera of female MS patients (0.05±0.01 U/ml, n=50) compared with the control group (n=40). We confirmed this result using real-time polymerase chain reaction (RT-PCR) which also showed a significantly higher EBV load in MS patients (22.61±12.72 copies/ml) as compared to the control. This was associated with an increased level of IL-17A (96.13±27.60 pg/ml) in the patients, while levels of both melatonin hormone (0.63±0.19 pg/ml) and vitamin D3 (29.90±12.41 ng/ml) showed a significant decrease as compared to the normal values of the control group. Analysis of the relation between each of the studied parameters with the level of disability in the patients, as reflected by the expanded disability status score (EDSS), revealed no significant differences between the two categories of EDSS ˂3 and ≥3 patients in terms of EBV EBNA1IgG levels, whereas they were slightly different in terms of IL-17A and vitamin D3 (p <0.001). With respect to differences between the treatment lines, the results from the showed analysis of variance (ANOVA) test showed no significant differences in all the tested parameters between patients treated with the first line (Rebif, Avonex, Betaferon) and second-line (Gilenya, Tysabri). However, the only significant difference in comparison to the control group was found in levels of IL-17. It could be concluded that EBV has a crucial role in the initiation and targeting MS disease, leading to increasing levels of IL-17A, and decrease serum levels of melatonin hormone for female patients.

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“…The results of the measurement of serum interleukin-17 levels showed significantly higher levels (P≤0.001) in pregnant women (468.38±50.62 Pg/ml) as compares to non-pregnant ones (144.39±3.98 Pg/ml), as shown in Table -2 Studies previously explained that serum IL-17 levels increase significantly in pregnant women at the third trimester in comparison with the beginning of the first trimester. The mean level of 17 increased up with the period of pregnancy to the last trimester [20,21,22]. Another study revealed no significant differences in the proportion of IL-17 cells among pregnant and non-pregnant women [23].…”

Section: Resultsmentioning

confidence: 93%

The Correlation between Maternal Vitamin D and Interleukin-17 Levels and Fetal Biophysical Profile

mohammed

Salih

2021

eijs

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This research aims to evaluate the serum levels of vitamin D and interleukin 17 (Il-17) in pregnant women, then finding the correlation between these maternal parameters and fetus biophysical profile. Healthy pregnant women (n=45) and non-pregnant control (n=45) were involved in the study, who attended Baghdad medical laboratory, Baghdad, Iraq, with an age range of 20 to 40 years. An analytical study was conducted from October 2019 until January 2020. The results of the study show that the mean value of vitamin D level significantly increases (P≤0.05) in pregnant women (11.07±0.93 ng/ml) in comparison with that in non-pregnant control (8.03±0.69 ng/ml). The level of IL-17 was significantly higher (P≤0.001) in the pregnant women (468.38±50.62 Pg/ml) as compared to non-pregnant ones (144.39±3.98 Pg/ml). Also, the results show no significant correlation (0.162) between maternal vitamin D and (F.H.R.), which was measured by ultrasound sonography. Also, there is no significant inverse correlation between maternal Il-17 and fetal growth measurement. It can be concluded from the current study that some of the signs of the physical appearance of the fetus that were studied in the second trimester (13-28 w) and third trimester (29-41 w) of pregnancy do not correlate with the level of vitamin D in the mother’s blood. Also, there is a weak inverse relationship between this appearance and the mother’s immune response, represented by measuring the level of IL-17, which needs more studies in the future.

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A Study of the Association Between IL-17 and HOMA-IR in Iraqi Type 2 Diabetic Patients

Cited by 13 publications

References 26 publications

Association of Serum Urotensin-II Levels with Insulin Resistance and Endothelin-I in Type-II Diabetes Mellitus Patients

Association of Serum Urotensin-II Levels with Insulin Resistance and Endothelin-I in Type-II Diabetes Mellitus Patients

Impact of EBV on Multiple in a Sample of Iraqi Females: Immunological and Molecular Study

The Correlation between Maternal Vitamin D and Interleukin-17 Levels and Fetal Biophysical Profile

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