A Study of the Diuretic Action of Acid Producing Salts

Gamble, James L.; Blackfan, Kenneth D.; Hamilton, Bengt

doi:10.1172/jci100019

Cited by 133 publications

(65 citation statements)

References 7 publications

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“…Such an event has been observed in fasting children by Gamble, Ross, and Tisdall (20) and in children with severe diarrhea by Butler, McKhann, and Gamble (21). Large losses of potassium have been reported following the use of acid-producing salts in rabbits by Goto (19) and moderate losses in human patients by Gamble, Blackfan, and Hamilton (22). The sodium losses, described above, are accompanied in the experiments where the animals received water as desired by such losses of body water as to result in but small serum sodium dilutions.…”

Section: Discussionmentioning

confidence: 88%

Salt and Water Losses in Diuretin Diuresis and Their Relation to Serum Non-Protein Nitrogen and Electrolyte Concentrations

Kerpel-Fronius

Butler

1935

Journal of Experimental Medicine

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The losses of sodium, potassium, chloride, nitrogen, and water following the administration of diuretin to rabbits over 5 to 9 day periods together with the changes in serum concentrations of sodium, chloride, N. P. N., and total protein occurring simultaneously with these losses are described. The circumstances responsible for the presence of azotemia in the animals were investigated in particular and the dependence of nitrogen retention upon dehydration and the modification of this dependence by variation in urine volume were demonstrated. It was clearly shown that no direct relationship exists between the azotemia and the coincident hypochloremia. It was found that nitrogen retention can be removed by the administration of water without salt, and the extent to which serum electrolyte and protein concentrations can be lowered by this procedure was also observed. The withdrawal from the body of large amounts of potassium as well as of sodium and chloride following the administration of diuretin, and also the inefficacy of sodium chloride solution in preventing the potassium loss was demonstrated.

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Section: Discussionmentioning

confidence: 88%

Salt and Water Losses in Diuretin Diuresis and Their Relation to Serum Non-Protein Nitrogen and Electrolyte Concentrations

Kerpel-Fronius

Butler

1935

Journal of Experimental Medicine

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“…That acidifying salts containing anions other than chloride potentiate diuresis may be explained by postulating that these anions either (1) substitute for chloride, or (2) allow for an increase in the concentration of chloride in the body fluids. Evidence for the second viewpoint is provided by the studies of Gamble and associates (39). These authors have shown that the administration of ammonium sulfate leads to elevation of the serum chloride concentration.…”

Section: Discussionmentioning

confidence: 99%

Electrolyte Equilibrium During Mercurial Diuresis 12

Schwartz¹,

Wallace²

1951

J. Clin. Invest.

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“…Studies on non-aquatic organisms, such Ž . Ž as humans Gamble et al, 1925, bovines Oetzel . Ž et al, 1991Goff andHorst, 1993 andrats Clas-.…”

mentioning

confidence: 99%

Dietary Ca inhibits waterborne Cd uptake in Cd-exposed rainbow trout, Oncorhynchus mykiss

Zohouri

Pyle

Wood

2001

Comparative Biochemistry and Physiology Part C: Toxicology &

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The effects of chronic exposure to waterborne Cd and elevated dietary Ca, alone and in combination, were examined Ž . w in juvenile rainbow trout, Oncorhynchus mykiss. Fish were chronically exposed to 0.05 control or 2.56 grl Cd as Ž . x Ž . Ž Cd NO и 4H O and were fed 2% body massrday of control 29.6 mg Carg or Ca-supplemented trout food 52.8 mg uptake from water into the gill and induced hypocalcemia in the plasma on day 40. Waterborne Cd also induced an elevated Ca concentration on day 20 in the gill tissue of trout fed the Ca-supplemented diet and a decreased Ca concentration on day 35 in the gills of trout fed the control diet. Dietary Ca protected against Cd accumulation in gill, liver, and kidney, but did not protect against the inhibition of Ca uptake into the gill or plasma hypocalcemia. When fed Ca-supplemented diet and exposed to waterborne Cd, fish showed 35% mortality, compared to 0᎐2% in control fish and in the Cd-exposed fish with normal Ca in the diet. Growth, on the other hand, was not affected by any treatment. ᮊ

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A Study of the Diuretic Action of Acid Producing Salts

Cited by 133 publications

References 7 publications

Salt and Water Losses in Diuretin Diuresis and Their Relation to Serum Non-Protein Nitrogen and Electrolyte Concentrations

Salt and Water Losses in Diuretin Diuresis and Their Relation to Serum Non-Protein Nitrogen and Electrolyte Concentrations

Electrolyte Equilibrium During Mercurial Diuresis 12

Dietary Ca inhibits waterborne Cd uptake in Cd-exposed rainbow trout, Oncorhynchus mykiss

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