Among patients with unstable angina or myocardial infarction without ST-segment elevation, prasugrel did not significantly reduce the frequency of the primary end point, as compared with clopidogrel, and similar risks of bleeding were observed. (Funded by Eli Lilly and Daiichi Sankyo; TRILOGY ACS ClinicalTrials.gov number, NCT00699998.).

Gamble, Ross, and Tisdall (1) originally pointed out that electrolytes and water were lost from the body during fasting in a manner which could be reasonably predicted from the concentration of salts in the body fluids. This concept is the basis for the study of changes in body composition by examination of electrolyte balance and weight changes. Darrow, Da Silva, and Stevenson (2) elaborated the method of calculation and showed that shifts of sodium between extracellular and intracellular fluid could be inferred in certain conditions from balance measurements. In this laboratory, studies in both man and animals (3, 4) have frequently demonstrated losses or gains of sodium which cannot be reasonably explained on the basis of shifts so calculated. Two possible explanations are: (a) Unmeasured skin losses may lead to the calculation of erroneously large retentions, or (b) Electrolyte may be sequestered in the body in an osmotically inactive form quickly available to the body fluids. Flanagan, Davis, and Overman (5), studying both balances and composition of tissues in dogs with adrenal insufliciency, noted such discrepancies and suggested that bone might serve as a sodium reservoir.The early work of Gabriel (6) demonstrated the presence of substantial amounts of sodium in the chloride-free residue of bone extracted with alkaline glycol solutions. Harrison, Darrow, and Yannet (7) showed that the ratio of sodium to chlonde in the skeleton is greatly in excess of that found in a plasma ultrafiltrate, and defined this as "extra" bone sodium. Subsequent investigators have confirmed these findings (8, 9), and Kaltreider, Meneely, Allen, and Bale (8), Stern, Cole, Bass, and

When adjusted for body size, gymnasts had significantly greater indices of both axial strength and bending strength at the NN region of the PF and S, as well as a greater bone SI at the femoral shaft. These differences may be related to greater relative lean body mass attained in gymnastics training.

No government in Europe remains sovereign in the sense understood by diplomats or constitutional lawyers of half a century ago. Within the 15-member EU mutual interference in each other's domestic aairs has become a long-accepted practice. Its extra-territorial jurisdiction extends across Norway, Switzerland and Iceland, states which recognize the supremacy of EU rules as an unavoidable consequence of their dependence on open access to its economic and social space. West European security is managed through NATO, an integrated alliance with joint commands, a (small) common budget and a number of multinational units. European security is managed through the Organization for Security and Cooperation in Europe, whose rules requiring transparency' in military forces and deployments are reinforced by the intrusive inspection procedures agreed under the Conventional Forces in Europe Treaty.The legitimate units within these institutions remain states. Representatives of Luxembourg and Denmark take their place round the table in NATO ministerial meetings, in EU Councils, and in the extensive network of committees through which these and other European institutions operate; representatives of Scotland and Bavaria do not. Yet the interaction of these thousands of representatives, engaged in multiple continuous negotiations, information exchange, coalition-building, informal trade-os among likeminded ocials and ministers in dierent governments, is of an entirely dierent quality from the monolithic external sovereignty of the nineteenth century European state. Ministers' diaries are ®lled with multilateral meetings, and with rounds of bilateral consultations to prepare for them. Ocials from every major department within national governments travel abroad, up to 2±3 days a week, to sit together in committees and to consult informally. 1 Military and police ocers, customs and immigration ocials train together and work together. To a remarkable degree, the processes of government in Europe overlap and interlock: among dierent states, between dierent levels of governance below and above the old locus of sovereignty in the nationstate. 2 States, furthermore, are not the only signi®cant actors within these institutions. The secretariats and parliamentary assemblies of NATO and WEU play

No abstract