A study of the effectiveness of chemosurgery with trichloroacetic acid for Japanese cedar pollenosis in terms of the chemical mediator levels in the nasal discharge and results of nasal provocation testing

Yao, Kazuo; Sato, Kentaro; Usui, Daisuke; Kurihara, Rika; Iguchi, Yoshiaki; Nishiyama, Koichiro; Liu, Tianyi; Kamijo, Takahiro; Masaki, Takashi; Okamoto, Makito

doi:10.1016/j.anl.2005.03.005

Auris Nasus Larynx

2005

DOI: 10.1016/j.anl.2005.03.005

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A study of the effectiveness of chemosurgery with trichloroacetic acid for Japanese cedar pollenosis in terms of the chemical mediator levels in the nasal discharge and results of nasal provocation testing

Kazuo Yao

Kentaro Sato

Daisuke Usui

et al.

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Cited by 5 publications

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“…The intranasal application of TCA is of particular interest. TCA has been successfully utilized for chemosurgery of allergic rhinitis for over 25 years 41‐51 . The application of 50% or 80% TCA solution modulates nasal epithelial cells—a docking point of airborne allergens (ie, pollens) and the allergen itself, which leads to significant improvement in nasal obstruction, sneezing, and watery nasal discharge.…”

mentioning

confidence: 99%

“…52,53 Histologic examination of the treated nasal mucosa showed gradual recovery of its normal function within 1 to 3 years after application without any serious side effects. 41,47 Initially blocked immunological function of the ciliated nasal epithelium was also found gradually recovering. 45,[48][49][50][51][52][53][54][55] This procedure does need to be preceded by anesthesia.…”

mentioning

confidence: 99%

“…A single application to the mid‐ and inferior turbinate and the adjacent mid‐portion of the septum by swab stick impregnated with TCA solution for 1 min is usually sufficient 52,53 . Histologic examination of the treated nasal mucosa showed gradual recovery of its normal function within 1 to 3 years after application without any serious side effects 41,47 . Initially blocked immunological function of the ciliated nasal epithelium was also found gradually recovering 45,48‐55 …”

mentioning

confidence: 99%

“…TCA has been successfully utilized for chemosurgery of allergic rhinitis for over 25 years. [41][42][43][44][45][46][47][48][49][50][51] The application of 50% or 80% TCA solution modulates nasal epithelial cells-a docking point of airborne allergens (ie, pollens) and the allergen itself, which leads to significant improvement in nasal obstruction, sneezing, and watery nasal discharge. It was demonstrated to have an indirect positive effect on the lower respiratory tract, influencing the development and modulating the course of allergic asthma.…”

mentioning

confidence: 99%

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COVID ‐19: Topical agents and therapeutic prevention of nasal viral acquisition

Abdelhadi

Ruszczak

Schwartz

2020

Dermatologic Therapy

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Since the spread of SARS‐CoV‐2 became a pandemic, the number of cases has been continuously growing worldwide. Numerous recommendations and suggestions have been published to prevent the acquisition and spread of the SARS‐CoV‐2, especially to protect health workers and front‐line caregivers. SARS‐CoV‐2 is transmitted by aerosol, rendering air defense with suitable ventilation and adequate mask use pivotal. Recently, locally applied antiseptic, antiviral, or structure competitive receptor blockers were suggested to attack the virus at its main point of invasion, the nasal mucosa and nasopharynx. We discuss the most plausible and safe ideas to reduce viral load at the point of entry, and subsequently the spread of SARS‐CoV‐2 to the lower respiratory tract, lungs, and other organs. In addition, we analyze the value and recommend clinical trials employing topical trichloroacetic acid (TCA), a substance well known from dermatologic and cosmetic procedures. It has been proven to successfully block the nasal entry for airborne allergens, preventing the development of allergic rhinitis and asthma, and to be curative for early stages of viral infections entering through the oral mucosa. For SARS‐CoV‐2, TCA in a single, short‐time application is expected to remodel the nasal and nasopharyngeal epithelia, eliminating both the receptors and cells responsible for viral entry and subsequent viral spread to the lower respiratory tract. Moreover, this may have therapeutic benefits for those recently infected by reducing local viral replication. Such procedures are cheap, safe, and can be conducted in almost every setting, especially in regions with inadequate financial and logistic resources.

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confidence: 99%

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confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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COVID ‐19: Topical agents and therapeutic prevention of nasal viral acquisition

Abdelhadi

Ruszczak

Schwartz

2020

Dermatologic Therapy

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“…6 Nasal TCA application has been reported as a "chemosurgery" treatment for patients with rhinitis through chemical cautery of the epithelium and subepithelium with associated protein degeneration. [7][8][9][10] Using our TCA nasal injury model, we determined the benefits of the corticosteroid pretreatment on preventing epithelial and cellular damage.…”

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confidence: 99%

Topical Corticosteroid Pretreatment Mitigates Cellular Damage After Caustic Injury to the Nasal Upper Airway Epithelium

Huang

Velasquez

Nguyen

et al. 2019

Am J Rhinol�Allergy

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Background Topical corticosteroids are currently employed to reduce established airway inflammation; their prophylactic use might help limit cellular damage against harmful stimuli. Objectives To determine the effects of a prophylactic topical application of budesonide (BD) on an in vivo nasal epithelium injury model induced by trichloroacetic acid (TCA). Methods C57Bl/6 mice were exposed to intranasal TCA topical application. Three groups received topical intranasal BD, saline solution, or no intervention prior to a single topical exposure to TCA. Controls were not exposed to TCA. Whole nasal cavity coronal sections were analyzed at 1, 3, and 6 days postinjury at tissue and cellular levels using histopathological analysis, immunofluorescent staining, and fresh tissue RNA microarray analysis. Results Prophylactic topical corticosteroid exposure protected the nasal epithelium from acute damage, maintaining epithelial thickness and cell survival. Six days following TCA exposure, epithelial and cellular changes were less pronounced on the BD-treated group compared to all exposure groups. The microarray analysis was used to evaluate the gene transcripts in all treatment groups. Ciliary tip protein, Sentan, and submucosal protein S100b were identified as potential factors in epithelial airway protection; immunofluorescent staining corroborated their presence and location within the respiratory epithelium. Conclusion Topical corticosteroid treatment to the nasal epithelium can mitigate several of the early deleterious effects of acute epithelial damage in experimental airway injuries caused by TCA. These findings suggest a novel, direct cytoprotective effect of corticosteroids on the nasal epithelium, and the potential of expanding the use of prophylactic periprocedural topical corticosteroids for respiratory epithelial tissues.

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Interrupting aerosol spread and nasal acquisition of SARS-CoV-2 with topical trichloroacetic acid

Ruszczak¹,

Dimitrov²,

Abdelhadi³

et al. 2022

Ital J Dermatol Venereol

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A study of the effectiveness of chemosurgery with trichloroacetic acid for Japanese cedar pollenosis in terms of the chemical mediator levels in the nasal discharge and results of nasal provocation testing

Cited by 5 publications

References 17 publications

COVID ‐19: Topical agents and therapeutic prevention of nasal viral acquisition

COVID ‐19: Topical agents and therapeutic prevention of nasal viral acquisition

Topical Corticosteroid Pretreatment Mitigates Cellular Damage After Caustic Injury to the Nasal Upper Airway Epithelium

Interrupting aerosol spread and nasal acquisition of SARS-CoV-2 with topical trichloroacetic acid

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