A study of the extent and pathology of experimental avulsion injury in rabbit arteries and veins

Mitchell, Geraldine M.; Morrison, Wayne A.; Papadopoulos, O.; O’Brien, Bernard McC.

doi:10.1016/0007-1226(85)90064-5

Cited by 62 publications

(50 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, initial assessment of perfusion to a revascularized digit is dependent upon arterial inflow. Histologic studies of traumatized vessels tend to support this scenario in which extensive arterial intimal disruption is found after avulsion injuries (Mitchell, et al, 1985;Mitchell, et al, 1986). However, the findings of the present study suggest that venous thrombosis may ensue after avulsion injuries which can be tolerated by arteries.…”

Section: Discussionsupporting

confidence: 52%

See 1 more Smart Citation

Thrombosis and Altered expression of Intercellular Adhesion Molecule-1 (Icam-1) after Avulsion Injury in Rat Vessels

Isogai

Tanaka

Asamura

2004

Journal of Hand Surgery

View full text Add to dashboard Cite

This study was undertaken to characterize the relative degrees of arterial and venous trauma after graded avulsion injuries. Rat femoral arteries and veins were subjected to reproducible avulsion injuries using forces of between 60 and 220g. Thrombotic occlusion occurred at lower avulsion forces in veins than in arteries. Histologic and scanning electron microscopic analysis indicated increased endothelial disruption and exposed elastic lamina with increasing avulsion force in both vessels, but more prominently in arteries. Intercellular adhesion molecule-1 (ICAM-1) mRNA expression was evident at 3 and 6 hours after avulsion injury in veins, but only with higher avulsion-force injuries in arteries. ICAM-1 mRNA expression was not found in either vessel before or after this 3 to 6 hour post-injury interval. These results indicate that the amount of avulsion force to which traumatized extremity vessels are subjected has a direct effect on the degree of intimal injury and subsequent thrombosis.

show abstract

Section: Discussionsupporting

confidence: 52%

“…(Mitchell et al, 1985(Mitchell et al, , 1986. Reports on the effects of crush and avulsion injuries to veins have been scarce.…”

Section: Introductionmentioning

confidence: 99%

Thrombosis and Altered expression of Intercellular Adhesion Molecule-1 (Icam-1) after Avulsion Injury in Rat Vessels

Isogai

Tanaka

Asamura

2004

Journal of Hand Surgery

View full text Add to dashboard Cite

show abstract

“…Veins tend to avulse more easily than arteries because of their thinner walls. 8 Weil et al 4 have recommended microvenous reconstruction for class IIC injuries and presented 5 patients with excellent results. In the same report an additional patient who seemed initially to have adequate venous drainage had lost his finger because of gradual congestion and necrosis.…”

Section: Discussionmentioning

confidence: 99%

The value of medical leeches in the treatment of class IIC ring avulsion injuries: Report of 2 cases

Tuncali

Terzioglu

Cigsar

et al. 2004

The Journal of Hand Surgery

View full text Add to dashboard Cite

“…3 The main problem in crush and avulsion injuries is to estimate the extent of the vascular trauma. 4,5 Examining vessels under the operating microscope will be decisive in determining when resection reaches a healthy zone. Vein grafts are then usually needed for revascularization.…”

mentioning

confidence: 99%

“…Experimentally, avulsion injury to rabbit femoral vessels was shown by electron microscopy to extend as far as 4 cm from the rupture site, compared with 0.8 cm observed with the operating microscope. 5 The extensive nature of these lesions is the main reason for the lower success rate of avulsed digits in replantation surgery. Under these circumstances, arterial revascularization is best performed by vein-graft implantation.…”

mentioning

confidence: 99%

Microvascular repair following crush‐avulsion type injury with vein grafts: Effect of direct inhibitors of thrombin on patency rate

et al. 2003

View full text Add to dashboard Cite

The aim of this study was to develop a standardized effective thrombogenic arterial anastomosis model, as usually encountered in clinical practice, and to offer a detailed evaluation of the antithrombotic effect of thrombin's direct inhibitors, antithrombin III and hirudin, as locally applied. Wistar rats were divided into four groups of 12 animals each. The carotid artery sustained a standardized crush-avulsion-type injury (groups B-D). A segment of the afflicted area was removed and replaced by a microvenous graft. Group A had no crush-avulsion injury inflicted; a microvenous graft replaced a simple resection from the center of the carotid artery. During microvascular anastomoses, normal saline (groups A and B), recombinant hirudin (group C), or antithrombin III (group D) were locally applied. Bleeding times were recorded, and patency tests were performed 20 min, 48 h, and 1 week after blood flow reestablishment. All grafts were harvested and examined histologically. Patency tests, 1 week postrevascularization, demonstrated that this experimental crush-avulsion injury model ensured low patency in group B (25%), whereas group A, which had no injury inflicted, achieved a 100% patency rate. The local application of hirudin and antithrombin III significantly increased bleeding times as well as the patency rate (92% and 75%, respectively) compared to group B. These findings indicate the efficiency of the experimental model and the potential use of thrombin's direct inhibitors in microvascular surgery.

show abstract

A study of the extent and pathology of experimental avulsion injury in rabbit arteries and veins

Cited by 62 publications

References 6 publications

Thrombosis and Altered expression of Intercellular Adhesion Molecule-1 (Icam-1) after Avulsion Injury in Rat Vessels

Thrombosis and Altered expression of Intercellular Adhesion Molecule-1 (Icam-1) after Avulsion Injury in Rat Vessels

The value of medical leeches in the treatment of class IIC ring avulsion injuries: Report of 2 cases

Microvascular repair following crush‐avulsion type injury with vein grafts: Effect of direct inhibitors of thrombin on patency rate

Contact Info

Product

Resources

About