“…Earlier studies and prevailing wisdom assumed that growth failure was due to the underlying disorder [Dietz, 1989] or to some set of factors linked with the underlying disorder. Various investigators have suggested that the etiology of growth failure in these children is due to central nervous system damage [Palmer, 1986], lack of normal activity and altered energy expenditure [Phelps, 1951;Ruby and Matheny, 1962;Eddy et al, 1965;Berg and Isaksson, 1970;Shapiro et al, 1986;Bandini et al, 1991], limb atrophy and scoliosis [Sanders et al, 1990], and chronic malnutrition [Leamy, 1953;Patrick et al, 1986;Gisel and Patrick, 1988;Sanders et al, 1990]. Recently, studies have focused more specifically on the impact of under nutrition or frank malnutrition as the most frequent cause of growth failure, particularly among severely affected children.…”