A study of the inclusion complex of naproxen with β-cyclodextrin

Facile Preparation and Extensive Characterization of Naproxen–β-Cyclodextrin Inclusion Complex

“…The maximum absorption wavelength of naproxen is 330 nm, which is according to the reported Ref. [12]. In addition, b-CD has no absorption interference at the scanning wavelength.…”

“…Naproxen and b-CD with 1:1 molar ratio were mixed with water and sealed in a flask. Then the mixture solution was stirred at room temperature for 24 h and freeze-dried [12].…”

“…The aliquot was filtered and diluted for UV spectrum analysis at k = 330 nm. The apparent formation constant, K c , was calculated from the straight line portion of the phase solubility diagram according to the following equation: K c = slope/(intercept(1 -slope)) [12].…”

“…The inclusion interaction of b-CD has received great attention in the past few decades [9][10][11][12][13][14]. b-CD has been authorized for use as the inclusion compound of drugs.…”

Aspectos biofarmacêuticos da formulação de medicamentos para neonatos: fundamentos da complexação de indometacina com hidroxipropil-beta-ciclodextrina para tratamento oral do fechamento do canal arterial

“…O grau de ulcerogenicidade depende destes mecanismos de defesa da mucosa celular ou dos processos bioquímicos afectados e da potência do efeito dos fármacos nesses processos. Para que um fármaco exerça efeito ulcerogênico, deve estar presente nas células da mucosa em concentração e tempo de permanência suficientes para desencadear os mecanismos de toxicidade (Erden, Çelebi, 1988;Liversidge et al, 1989;Menguy, Desbaillets, 1967;Rainsford, 1990;Somasundaram et al, 1997). Em geral, quando os AINEs são administrados por via oral são atingidas grandes concentrações nas células da mucosa gástrica.…”