A study of the intertransplantation of alveolar mucosa

Smith, Roy M.

doi:10.1016/0030-4220(70)90130-1

Cited by 18 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, transplantation experiments have snoring, and airway properties requires further investigations. shown that the features of the connective tissue do not change Such studies should elucidate the role of T cell subpopulations, when the entire tissue is relocated to areas in which different chemokines, growth factors, and matrix metalloproteinases in mechanical conditions prevail (50,51).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Upper Airway Epithelial Structural Changes in Obstructive Sleep-disordered Breathing

Paulsen

Steven

Tsokos

et al. 2002

Am J Respir Crit Care Med

113

View full text Add to dashboard Cite

The etiology of upper airway collapsibility in patients with snoring and obstructive sleep apnea (OSA) remains unclear. Structural mucosal changes could be contributory factors. The objective of this study was to determine whether pathologic changes in the epithelium or the epithelial-connective tissue interface are present in patients with snoring and/or OSA by means of scanning electron microscopy and immunohistochemistry. Uvulae were obtained by uvulopalatopharyngoplasty from three patients with habitual snoring and nine patients with mild to severe OSA, as well as by dissection from 43 nonsnoring body donors. Scanning electron microscopy revealed structural changes in the epithelial-connective tissue boundary that significantly differed from age-related changes in the control subjects. The immunohistochemical staining with antibodies against epithelial cytokeratins showed differences in the expression pattern of cytokeratin 13 between patients and control subjects. No differences were found in the distribution pattern of laminin. Analysis of defense cells revealed a significant diffuse infiltration of leukocytes, mainly T cells, inside the lamina propria of the patient group, which was not observed in the control group. In conclusion, these results support the hypothesis that progressive structural changes in the mucosa caused by the trauma of snoring are a possible contributory factor to upper airway collapsibility.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemical stains were done with antibodies against laminin [1: 50] . They were applied using a standard peroxidase-labeled streptavidin-biotin technique, either with microwave heating pretreatment or by using conventional methods with trypsinization where appropriate.…”

Section: Immunohistochemical Proceduresmentioning

confidence: 99%

Upper Airway Epithelial Structural Changes in Obstructive Sleep-disordered Breathing

Paulsen

Steven

Tsokos

et al. 2002

Am J Respir Crit Care Med

113

View full text Add to dashboard Cite

show abstract

“…Changes in tissue morphology can occur as a result of environmental stimuli. For exatnple, the epidermis may display an increased thickness of the keratin layer in response to abrasion (MacKenzie 1973), On the other hand, if split thickness grafts frotn skin or mucous membranes are transplanted to foreign sites on the surface of the body, the epithelium retains its original specificity (Krohti 1955, Billingliam & Silvers 1963, Smith 1970, These studies indicate that the characteristic features of the epithelium in various regions of the adult organistn are genetically determined rather than the result of functional adaptation. We have confirmed these findings in a previous study (Karring, 0stergaard & Loe 1971) in which tissue grafts of keratinized gingiva and non-keratinized alveolar mucosa were transposed.…”

mentioning

confidence: 99%

The role of gingival connective tissue in determining epithelial differentiation

Karring¹,

Lang²,

Löe³

1975

J of Periodontal Research

269

171

View full text Add to dashboard Cite

Free grafts of connective tissue, without epithelium, were transplanted from either the keratinized gingiva or the non-keratinized alveolar mucosa (controls) into areas of the alveolar mucosa in seven monkeys. The grafts were placed in pouches created in the connective tissue as close as possible to the overlying epithelium. After 3-4 weeks, the transplants were exposed by removal of the overlying tissue in order to allow epithelialization from the surrounding non-keratinized alveolar mucosa. The transplants were examined clinically and histologically at time peiods between 1 and 12 months. The gingival connective tissue grafts became covered with keratinized epithelium displaying the same characteristics as those of normal gingival epithelium. The alveolar mucosa transplants were covered with non-keratinized epithelium. This indicated that gingival connective tissue is capable of inducing the formation of a keratinized gingival epithelium.

show abstract

“…(Accepted for puhlicntion March 5,7977) introduction Recent work in the periodontal literature demonstrated the capacity of transplanted and transposed oral tissues to retain their tissue specificity in new sites, aiul provided evidence that the dcrmis of the donor tissue governed the nature of the epithelial covering over the grafted site (Smith 1970, Karring, Ostergaard & Loe 1971. Stambaugh & Gordon 1973, Plagmann ct al.…”

mentioning

confidence: 99%

Evaluation of resultant tissue type following the intraoral transplantatin of various lyophilized soft tissues

Yukna

Sullivan

1978

J of Periodontal Research

View full text Add to dashboard Cite

Epithelial regeneration was studied in Rhesus monkeys following the placement of fresh autogenous and lyophilized allogeneic soft tissue grafts in alveolar mucosa recipient sites. Two months postoperatively, histologic evaluation of biopsied graft areas showed that the autogenous free gingival graft controls, lyophilized allogeneic skin, and lyophilized allogeneic gingiva generally demonstrated a keratinized surfrace and other attributes of gingival‐type tissue. Lyophilized allogeneic mucosa universally yielde a non‐ or para‐ keratinized surface and a mucosa‐like corium. These findings reinforce the principle of dermal dictation of epithelial covering, demonstrate that lyophilized tissues retain their dermal specificity, and support the use of lyophilized allogeneic skin and gingiva in mucogingival surgery.

show abstract

A study of the intertransplantation of alveolar mucosa

Cited by 18 publications

References 8 publications

Upper Airway Epithelial Structural Changes in Obstructive Sleep-disordered Breathing

Upper Airway Epithelial Structural Changes in Obstructive Sleep-disordered Breathing

The role of gingival connective tissue in determining epithelial differentiation

Evaluation of resultant tissue type following the intraoral transplantatin of various lyophilized soft tissues

Contact Info

Product

Resources

About