A study of the lethal mechanism in experimental closed loop strangulated obstruction of the small intestine

Turner, Michael D.; Grogan, James B.; Truett, George

doi:10.1016/0002-9610(61)90562-1

Cited by 11 publications

(2 citation statements)

References 23 publications

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“…This is indicated by the somewhat decreased survival time in the germfree animals with rubber bags when compared with germfree animals without bags. The prolongation of the survival time in the conventional rats when the rubber bag was used is well in agreement with the findings of other investigators (1)(2)(3)8) in dogs and rabbits.…”

Section: Discussionsupporting

confidence: 92%

Results of Experimental Intestinal Strangulation Obstruction in Germfree Rats

Amundsen

Gustafsson

1963

The Journal of Experimental Medicine

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Numerous factors influence the pathological physiology of intestinal strangulation obstruction. Those originating from the strangulation fluid, i.e. the fluid produced b y the strangulated loop of intestine, have been a focus of interest for experimental studies during the past few years. This fluid is very toxic on intraperitoneal injection in healthy animals (1-3). Antibiotics diminish the toxicity (4-6) and there are findings which indicate that the content of Escherichia coli and of red blood cells in the strangulation fluid influence the toxicity of the fluid (7). The decisive influence attributed to the intestinal bacteria on the toxicity of the strangulation fluid (8, 9) prompted the following experiments in which clinical course, survival time, and toxicity of strangulation fluid were noted on germfree rats and conventional rats with experimentally produced low ileal strangulation obstruction.

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Section: Discussionsupporting

confidence: 92%

Results of Experimental Intestinal Strangulation Obstruction in Germfree Rats

Amundsen

Gustafsson

1963

The Journal of Experimental Medicine

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“…Several investigators have shown that strangulation fluid collected during the later stages of intestinal strangulation o'bstruction was lethal to recipient animals when injected into the peritoneal cavity (1,11). Positive blood cultures were found in dogs receiving a lethal dose of strangulation fluid intraperitoneally (18). Barnett & Sampson ( 2 ) suggested that the injection of lethal strangulation fluid caused impairment of body defence mechanisms, resulting in a lethal infection of the recipient animal.…”

Section: Discussionmentioning

confidence: 99%

Chemotactic Activity of Intestinal Strangulation Obstruction Fluid From Germfree and Conventional Rats

Trippestad¹,

Midtvedt²

1973

Acta Pathologica Microbiologica Scandinavica Section B Microbio

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The chemotactic activity of rat strangulation fluid on rat polymorphonuclear leucocytes was investigated. Chemotactic activity was demonstrated in strangulation fluid from conventional as well as from germfree rats. The chemotactic substances resisted heat treatment at 56° C for 30 min. The chemotactic activity was destroyed following heat treatment at higher temperatures. Dialysis did not remove the chemotactic activity. Gel‐filtration chromatography on Sephadex G‐100 of strangulation fluid from germfree rats resulted in fractions with three to four peaks of chemotactic activity. The possible relationship to the complement system was discussed.

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A study of bacteria and lethal factors in fluids from experimental intestinal obstruction in dogs

Nagy

Weipers

1968

J. Pathol.

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LETHAL factors associated with the operation of closed intestinal loop of the small intestine in dogs are known to be complex, and a number of factors may require to be operative before the final and usually irreversible episode of shock supervenes (Weipers, Harper and Warrack, 1964).There is a general recognition that the shock syndrome that develops is similar in nature to that produced by other causes such as the presence of endotoxin or protracted haemorrhage with hypotension. It appears in all these to be associated with the action of increased catecholamine output, extensive vasoconstriction and the sequence of cardiovascular events associated with anoxia of the intestine terminating rapidly in death. The post-mortem lesions in dogs are characterised by haemorrhage, ulceration and necrosis of the mucous membrane of the small intestine (Lillehei et al., 1964). Surgery, 43, 595. This Journal, 74, 185. AddendumRecent work has shown that an injection of cell-free peritoneal fluid from cases of intestinal obstruction, given over a period of a few hours, may be lethal. The finding that bacteria have an important part to play in the lethal effect of injected peritoneal fluid may apply only when a single injection is given.

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A study of the lethal mechanism in experimental closed loop strangulated obstruction of the small intestine

Cited by 11 publications

References 23 publications

Results of Experimental Intestinal Strangulation Obstruction in Germfree Rats

Results of Experimental Intestinal Strangulation Obstruction in Germfree Rats

Chemotactic Activity of Intestinal Strangulation Obstruction Fluid From Germfree and Conventional Rats

A study of bacteria and lethal factors in fluids from experimental intestinal obstruction in dogs

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