A Study of the Metabolic Requirements for the Contractile Action of Angiotensin Upon Guinea‐pig Ileum

Crocker, Ann D.; Wilson, Keith A.

doi:10.1111/j.1476-5381.1974.tb09634.x

Cited by 5 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may also indicate that effects are not cholinergically mediated (Milenov & Golenhofen, 1987). In other tissues, such as guinea-pig ileum, direct effects on muscle strips as well as cholinergically mediated ones have been discussed (Godfraind & Polster, 1966;Crocker & Wilson, 1974).…”

Section: Duodenummentioning

confidence: 99%

“…In vivo studies have demonstrated a delay in gastric emptying in the rat (Scarpignato, Manfredi, Starcich & Bertaccini, 1983) while in man a closure of the lower oesophageal sphincter has been found (Haulica et al, 1980). In vitro studies on small intestine and colon of various species, such as the guineapig, rat and man, have demonstrated contractions of isolated smooth muscle prepartions after application of angiotensin I1 with thresholds between and mol 1-' (Blair-West & McKenzie, 1966;Godfraind & Polster, 1966;Fishlock & Gunn, 1970;Chong & Downing, 1973;Bertaccini, Impicciatore, Molina & Zappia, 1974;Crocker & Wilson, 1974;Ercan & Turker, 1977;Zetler, 1979).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Angiotensin II stimulates human gastric smooth muscle in vitro

Lüdtke

Golenhofen

Schubert

1989

Journal of Autonomic Pharmacology

View full text Add to dashboard Cite

1. For a precise analysis of angiotensin II (ANG) effects on human gastric muscle, we dissected longitudinal (lo) and circular (ci) strips from fundus (Fu), corpus (Co) and antrum (An), and circular muscle from the inner and outer part of the pyloric sphincter (Py-inn and Py-out) and from duodenum. The mechanical activity of these muscle strips was recorded simultaneously under auxotonic conditions. Preparations were taken from a total of 10 stomachs (from organ donors or gastrectomy preparations). 2. Excitatory effect after application of ANG (10(-9) to 10(-6) mol l-1) were regularly observed in all types of preparation (threshold: 10(-9) mol/l). 3. The quality of the responses depended on the general characteristics of the type of preparation. Tonic types of muscle showed predominantly tonic responses to ANG (Fu-lo, Fu-ci, Co-lo). Purely phasic muscles (An-ci) showed increases of the phasic activity (amplitude up to 33% delta 1). Intermediate types of muscle exhibited combined phasic/tonic responses (Co-ci, An-lo). Phasic responses were also seen in Py-out. Inner pyloric muscle (Py-inn) responded only to a small extent to ANG. Phasic/tonic activations were observed in the duodenal preparations, accompanied by slight increases in frequency. 4. The intensity of the ANG-induced responses often exceeded the maximum acetylcholine-induced activation. The qualitative pattern of ANG responses was similar to that of bombesin-induced activation.

show abstract

Section: Duodenummentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Angiotensin II stimulates human gastric smooth muscle in vitro

Lüdtke

Golenhofen

Schubert

1989

Journal of Autonomic Pharmacology

View full text Add to dashboard Cite

show abstract

Peptides: Locally Active Peptides (“Vasoactive Peptides”)

Bertaccini¹

1982

Mediators and Drugs in Gastrointestinal Motility II

View full text Add to dashboard Cite

Paradoxical relationship between substrates and agonist-induced contractions of opossum esophageal body and sphincterin vitro

1991

View full text Add to dashboard Cite

Possible differences in the abilities of esophageal body and lower esophageal sphincter muscles to utilize substrates to support agonist-induced contractions were studied. Strips of longitudinal, circular, and lower esophageal sphincter muscle from the opossum esophagus were first contracted to approximately 70% of the maximal contraction elicited by acetylcholine, histamine, or substance P. The tissues were then exhausted by exposure to 5 x 10(-4) M carbachol and a 15% O2-5% CO2-80% N2 gas mixture for 90 min. They were next reequilibrated with one of a number of alternative substrates and 95% O2-5% CO2 for 3 hr. Responses to the initial agonist doses were again noted and compared to controls. The alternative substrates were: 2-deoxyglucose, glucose, fructose 1-6 diphosphate, pyruvate, lactate, acetate, butyrate, caprylate, histidine, leucine, aspartate, alanine, succinate, acetoacetone, and beta-hydroxybutyrate. The results obtained show qualitative differences in the ability of the three muscle types to use these substrates. More importantly, however, the ability of any one substrate to support contractions was a function of the agonist used to stimulate the muscle. The evidence suggests, therefore, that not all pharmacologic receptors have equal access to intracellular energy sources.

show abstract

A Study of the Metabolic Requirements for the Contractile Action of Angiotensin Upon Guinea‐pig Ileum

Cited by 5 publications

References 13 publications

Angiotensin II stimulates human gastric smooth muscle in vitro

Angiotensin II stimulates human gastric smooth muscle in vitro

Peptides: Locally Active Peptides (“Vasoactive Peptides”)

Paradoxical relationship between substrates and agonist-induced contractions of opossum esophageal body and sphincterin vitro

Contact Info

Product

Resources

About