A study of the radiographic and histological changes occurring in Legg‐Calve‐Perthes Disease (LCP) in the dog

Lee, R.

doi:10.1111/j.1748-5827.1970.tb05623.x

Cited by 22 publications

(23 citation statements)

References 4 publications

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“…As the disease progresses, increasing volumes of granulation tissue are histologically identified, particularly at the junction of necrotic and live bone, with evidence of active revascularization and new bone formation. 22 Similarly, the ACB in the dog of the present report had a moth-eaten radiographic appearance with cortical thinning. Also, histologic findings for the ACB in the dog included necrotic bone, fibroblastic tissue proliferation, and granulation tissue.…”

Section: Discussionsupporting

confidence: 64%

Idiopathic ischemic necrosis of an accessory carpal bone in a dog

Harris¹,

Langley‐Hobbs²

2013

javma

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Case Description—A 6-year-old neutered female mixed-breed dog was evaluated because of a 6-week history of left forelimb lameness that varied in severity. Clinical Findings—Radiography revealed expansile and lytic changes of the left accessory carpal bone (ACB). Results of histologic evaluation of ACB core biopsy specimens indicated areas of bone necrosis. The entire left ACB was excised and submitted for histologic evaluation; results confirmed a diagnosis of idiopathic ischemic necrosis. Treatment and Outcome—Left pancarpal arthrodesis was performed to treat carpal hyperextension and persistent lameness. The dog had an excellent functional outcome with no other problems related to the carpus until its death 4 years later, further decreasing suspicion that the problem was attributable to an undetected neoplasm or bacterial or fungal osteomyelitis. Clinical Relevance—The radiographic and histologic findings for the dog of this report were similar to previously reported findings for dogs with ischemic femoral head necrosis and humans with ischemic carpal (pisiform or lunate bone) necrosis. The etiology of the ischemic ACB necrosis in this dog was not determined. To the authors’ knowledge, this is the first report of a dog with idiopathic ischemic ACB necrosis. Idiopathic ischemic necrosis should be included as a differential diagnosis for dogs with lameness and destructive and expansile ACB radiographic lesions. An excellent functional outcome may be attained by means of ACB excision and pancarpal arthrodesis.

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Section: Discussionsupporting

confidence: 64%

Idiopathic ischemic necrosis of an accessory carpal bone in a dog

Harris¹,

Langley‐Hobbs²

2013

javma

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“…). Lee () describes a process of creeping substitution, where highly vascular granulation tissue invades the necrotic areas.…”

Section: Discussionmentioning

confidence: 99%

Avascular necrosis of the canine radial carpal bone: a condition analogousto Preiser's disease?

Aiken¹,

Stewart

Anderson³

2013

J of Small Animal Practice

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An eight-year-old male neutered Staffordshire bull terrier was presented for investigation of right forelimb lameness of 14 months' duration. Radiography showed mottled osteolysis of the right radial carpal bone. Histopathology of the bone demonstrated replacement of healthy bone with granulation tissue suggestive of ischaemic necrosis. Lameness resolved following pancarpal arthrodesis. In humans, Preiser's disease is a condition in which idiopathic ischaemic necrosis of the scaphoid bone, the equivalent of the canine radial carpal bone, occurs. This disease may be analogous to the presentation seen in this case. To the authors' knowledge, this is the first report of such a condition in a dog.

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“…The histopathologic and radiographic findings of the disease in dogs have been well documented 3,5–8 . However, the inciting cause in dogs usually remains unknown.…”

Section: Introductionmentioning

confidence: 99%

“…The typical progression is vascular compromise to the proximal femoral epiphysis that results in necrosis of the trabeculae and marrow tissue. Subsequent revascularization and formation of granulation tissue results in weakness, collapse of the subchondral bone, and secondary degenerative joint disease 3,6 …”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Imaging of the Femoral Head of Normal Dogs and Dogs With Avascular Necrosis

Bowlus

Armbrust

Biller

et al. 2008

Vet Radiology Ultrasound

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The purpose of this study was to describe the appearance of the femoral head of normal, young, small breed dogs, and dogs with avascular necrosis using low-field (0.3 T) magnetic resonance (MR) imaging. Images of the femoral heads were obtained in the dorsal plane, and included T1-weighted spin-echo, T2-weighted fast spin-echo, fast spin echo-inversion recovery, and fluid attenuated inversion recovery pulse sequences. MR imaging features of the asymptomatic femoral heads and necks included uniform high signal intensity compared with muscle on T1- and T2-weighted images. There was either uniform enhancement or no enhancement on postcontrast T1-weighted images. The MR imaging findings of dogs affected with avascular necrosis differed from those of asymptomatic dogs. Typically, the affected dogs had inhomogeneous intermediate to low-signal intensity within the femoral head and neck compared with muscle on T1-weighted images, inhomogeneous enhancement of the femoral head and/or neck on postcontrast T1-weighted images, and inhomogeneous low- to high- signal intensity within the femoral head and neck on T2-weighted images.

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A study of the radiographic and histological changes occurring in Legg‐Calve‐Perthes Disease (LCP) in the dog

Cited by 22 publications

References 4 publications

Idiopathic ischemic necrosis of an accessory carpal bone in a dog

Idiopathic ischemic necrosis of an accessory carpal bone in a dog

Avascular necrosis of the canine radial carpal bone: a condition analogousto Preiser's disease?

Magnetic Resonance Imaging of the Femoral Head of Normal Dogs and Dogs With Avascular Necrosis

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