A study of thyroid dysfunction in dysfunctional uterine bleeding

Verma, Santosh Kumar; Jaswal, Saroj

doi:10.18203/2320-1770.ijrcog20171972

Cited by 15 publications

(17 citation statements)

References 8 publications

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“…Parveen et al also found an incidence of 45% of heavy menstrual bleeding in their study. 25 Women with complaints of shortened cycles were 5% which was similar to in the study by Verma et al and Parveen et al 25,29 Thyroid disorders are common in females with subclinical hypothyroidism as it's the most common type. Menstrual irregularities are seen in both hyperthyroidism as well as hypothyroidism.…”

Section: Discussionsupporting

confidence: 72%

Association between thyroid disorders and abnormal uterine bleeding in reproductive ages

Shawl¹,

Naz²

2020

Int J Reprod Contracept Obstet Gynecol

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Background: Abnormal uterine bleeding (AUB) means any bleeding that is not normal in amount, duration, frequency, and cyclicity. It is a common disorder occurring in reproductive age group females. It can be understood as bleeding that occurs from the uterus outside the normal parameters and there are no structural defects in the genital tract. One of the most common associations with AUB is thyroid dysfunctions. Hence, this study aimed to see the incidence of thyroid-related disorders in AUB and also to assess the menstrual pattern.Methods: A total 100 women suffering from AUB who presented to OPD of the gynecology department of L D Hospital Srinagar, Jammu and Kashmir were recruited in the study. All females in 19 to 45 years of age group with abnormal uterine bleeding were included excluding those with a previously known thyroid disorder, abortion history within 3 months, etc. Thyroid function tests were done in all along with ultrasonography of the pelvis region. Data were analyzed using SPSS software v.23.0. and Microsoft office 2007.Results: The bleeding abnormality that was found in most of the women was heavy menstrual bleeding. Out of the 100 patients taken into study 11 had thyroid disorders, out of which subclinical hypothyroidism was most prevalent accounting for 8 cases, 2 cases were found to have hypothyroidism and 1 case of hyperthyroidism was detected.Conclusions: Abnormal uterine bleeding has a strong association with thyroid disorders. The most common type of disorder is subclinical hypothyroidism. Thus, all patient of AUB must be evaluated for thyroid dysfunction.

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Section: Discussionsupporting

confidence: 72%

Association between thyroid disorders and abnormal uterine bleeding in reproductive ages

Shawl¹,

Naz²

2020

Int J Reprod Contracept Obstet Gynecol

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“…The patients with thyroid disorders have comparatively higher mean BMI than the Euthyroid population due to obesity. Menorrhagia as the most common form of AUB pattern in the total population is supported by almost all the studies-Parveen et al (5) Verma et al (6) and Divya et al (7) Both subclinical and overt hypothyroidism associated with Menorrhagia, Acyclical bleeding and Polymenorrhagia as the most common AUB patterns is supported by studies conducted by Bhavani et al (8) and Sanghamitra et al (9) who showed menorrhagia in 73.4% and 62.5% respectively. The cause for Menorrhagia in most of these studies is said to be due multiple factors: Defective or delay in LH response leading to Luteal phase defect and anovulation due to GnRH pulsatile secretion which was due to TRH induced Hyperprolactinemia, Abnormal feedback at pituitary level due to decreased SHBG production thereby leading to altered peripheral metabolism of oestrogens, Altering coagulation factors (decrease in factors VII, VIII, IX, XI) causing Menorrhagia.…”

Section: Discussionmentioning

confidence: 76%

Correlation of Thyroid Disorders with Abnormal Uterine Bleeding (AUB)

Kolli¹,

Agrawal²,

Khithani³

et al. 2020

jemds

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BACKGROUND AUB is a common and complicated clinical entity. Thyroid disorders are the most common endocrine disorders in India with a prevalence of 26% in women and its incidence increases with age. Menstrual disturbances may accompany or may even precede thyroid disorders. We wanted to study the correlation between thyroid disorders and abnormal uterine bleeding in women of reproductive age group. METHODS This is cross-sectional study conducted on 165 subjects who fulfilled the eligibility criteria in the Department of OBGY, AVBRH, Sawangi for a period of 2 years. Thorough clinical examination, ultrasonography and thyroid function tests of the patients was done. RESULTS In this study, maximum number of patients were in the age group of 21-30 years. Regarding bleeding patterns, maximum patients had complaints of menorrhagia (46.06%). 77.58% of patients were euthyroid, 12.12% were subclinical hypothyroid, 17.88% were overt hypothyroid and 2.42% patients were hyperthyroid. Among both subclinical and overt hypothyroid patients, the most common menstrual irregularity was menorrhagia in 55% followed by polymenorrhagia, acyclical bleeding, polymenorrhoea, oligomenorrhoea and metrorrhagia. Among hyperthyroidism, the most common menstrual irregularity was oligomenorrhoea in 75% followed by hypomenorrhoea in 25%. CONCLUSIONS Our study concludes that the work up of any patient with AUB should essentially consist of T3 and T4 levels along with TSH levels as a mandatory part otherwise cases of subclinical hypothyroidism may be missed if only TSH levels are measured.

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“…Verma et al found that 74.3% of patients with hypothyroidisim had proliferative endometrium. 13 Padmaleela et al found in their study that the common finding in endometrial biopsy both in hypothyroid (60%) and hyperthyroid (57.1%) cases was proliferative endometrium. 14 Cystoglandular hyperplasia was found in 13.3% of hypothyroid patients.…”

Section: Discussionmentioning

confidence: 89%

Thyroid disorders in women with abnormal uterine bleeding: a tertiary hospital based cross sectional study from Puducherry, India

Ezhil

Nivedita

Shanthini

2018

Int J Reprod Contracept Obstet Gynecol

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Background: The most common complaint with which women present for gynecological consultation is abnormal uterine bleeding which may be due to varied etiology. Among non-structural causes for AUB, endocrinological disorders like thyroid dysfunction is very common. Thyroid dysfunction is often overlooked, and unnecessary hormonal or surgical interventions are performed in patients with AUB.Methods: This is a hospital based cross sectional study carried out in Sri Manakula Vinayagar Medical College and Hospital, Puducherry between January 2017 to June 2017 for a period of 6 months and the participants were 200 women attending gynecological OPD with complaints of abnormal uterine bleeding. After obtaining a written informed consent from the participants a detailed history and complete examination including a thorough gynecological examination was performed. A transvaginal ultrasound examination to note for any structural causes for AUB was performed. Thyroid function test (FT3, FT4, TSH) was performed in all study participants and they were then categorized into euthyroid, hypothyroid, hyperthyroid, subclinical hypo or hyperthyroid based on the results. After preliminary preparation all participants were subjected for an endometrial biopsy in the outpatient department and the tissue obtained was sent for histopathological analysis. All the information was tabulated and analyzed using SPSS 22 version with descriptive and inferential statistics (chi square test). A p value of < 0.05 was considered as statistically significant.Results: Heavy menstrual bleeding was the most common menstrual abnormality found in 85% of the study participants.77% had structural causes for AUB whereas 23% had non-structural causes. 79.5% of the patients with AUB were euthyroid whereas 20.5% had some form of thyroid dysfunction. Subclinical hypothyroidism was the most common thyroid dysfunction (15.5%) in this study followed by hypothyroidism (3.5%). Only 1.5% of patients had hyperthyroidism. In the present study no, significant association was found between any particular thyroid dysfunction and specific menstrual pattern or endometrial pattern in histopathology.Conclusions: Testing and treating for thyroid disorder would prove to be cost effective in patients with AUB particularly with nonstructural causes as it would avoid many costly interventions done for AUB.

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A study of thyroid dysfunction in dysfunctional uterine bleeding

Cited by 15 publications

References 8 publications

Association between thyroid disorders and abnormal uterine bleeding in reproductive ages

Association between thyroid disorders and abnormal uterine bleeding in reproductive ages

Correlation of Thyroid Disorders with Abnormal Uterine Bleeding (AUB)

Thyroid disorders in women with abnormal uterine bleeding: a tertiary hospital based cross sectional study from Puducherry, India

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