A Study of Torch Screening in Women with Bad Obstetric History

Abstract

Journal homepage: http://www.ijcmas.com Maternal infections have been considered as one of the significant factors in the causation of bad obstetric history. Infections caused by Toxoplasma, Rubella, Cytomegalovirus and Herpes simplex virus are benign. However, they may lead to serious complications, especially when they are acquired during the first trimester of pregnancy. These are associated with inadvertent outcomes like multiple abortions, intra-uterine fetal death, stillbirths and congenital malformations. Data regarding the detection of these infections is scanty as the risk requirement of expensive commercial diagnostic kit-Toxoplasma, Rubella, Cytomegalovirus and Herpes simplex IgM antibodies. This study was undertaken to assess the utility in pregnant women with bad obstetric history. The present study was undertaken as the case-control study at Princess Esra Hospital, Hyderabad between January 2015 and December 2017. A total of 50 pregnant women of age range in their first trimester attending Ante Nata Clinic were included along with 35 age matched control pregnant women with no bad obstetric history. After obtaining the institutional ethics committee approval serum samples were obtained aseptically from the enrolled cases and were tested for the identification of specific IgM antibodies for Toxoplasma, Rubella, Cytomegalovirus and Herpes using sandwich and capture ELIZA (Calbiotech lab USA). The assay was performed according to the manufacturer's instructions and the results were calculated in MS excel and test of proportion and Pearson's Chi square test. 23 women for IgM antibodies Toxoplasma, Rubella, Cytomegalovirus and Herpes either alone or in combination were identified in the group I. In the control group (Group II), IgM antibodies were detected in 11 cases. When compared with the control group, Rubella and Toxoplasma infection were found to have statistically significant difference with the pvalue of 0.016 and 0.026 respectively. However, there was no statistically significant difference found between the two study groups. Detection of IgM antibodies performed reflects recent infection and there is high prevalence of infection caused by TORCH agents in women with bad obstetric history compared to healthy controls. Hence, all the anti-natal cases with bad obstetric history should be routinely screened as IgM antibodies detection is a reliable indicator of maternal infections and can be used as a screening test. K e y w o r d s

Study to Evaluate Association of Torch Infection with Bad Obstetric History in Pregnant Women at Sms Medical College and Attached Group of Hospitals, Jaipur

“…In our study, Rubella IgM and IgG antibodies were 2.34% (3/130) and 93.75% (120/130) respectively. Our study is comparable with studies done by Tamer et al [46], Nabi SN et al [47], Padmavathy M et al [25], Shrivastava G et al [48] [54] in which the IgM seropositivity was 4%, 0%, 5.71%, 3%, 14.2% respectively.…”

“…According to our study, Toxoplasma specific IgM and IgG antibodies in pregnant women with bad obstetric history were 3.84% ( Similarly, the Toxoplasma specific IgM and IgG antibodies in pregnant women without bad obstetric history (controls) was 0% and 0.76% respectively which was comparable with the study of Surpam RB et al [51], Kumari N et al [52], Guddy et al [53], Saxena N et al (2015), Rasti S et al (2016), Mustafa M et al [54] in which the IgM seropositivity was 1.33%, 16.7%, 0%, 1.50%, 2.85%, 0% respectively.…”

Molecular Diagnosis of TORCH Infection of Pregnant Women in Iraq

“…BOH etiology may be genetic, hormonal, abnormal maternal, immune response, and maternal infection. Primary infections caused by TORCH agents form the major cause of BOH [2,3].Viral infections in pregnancy are major causes of maternal and fetal morbidity and mortality. Infections may affect the neonate transplacental, prenatal (from vaginal secretions or blood), or postnatal (from breast milk or other sources) [3,4].…”