A Study of Zinc Metabolism in Alcoholic Cirrhosis

Mills, Peter R.; Fell, G. S.; Bessent, R. G.; Nelson, L.M.; Russell, Robin

doi:10.1042/cs0640527

Cited by 50 publications

(14 citation statements)

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“…We noted impaired zinc absorption not only in the 5 alcoholic subjects with liver disease but also in the 13 subjects without clinical evidence of liver disease. This is in contrast to Mills et al [11]. who report an increased absorption of zinc in patients with alcoholic cirrhosis but not currently consum ing alcohol.…”

Section: Discussioncontrasting

confidence: 55%

Zinc Absorption in Alcoholics Using Zinc-65

Dinsmore¹,

Callender²,

McMaster³

et al. 1985

Digestion

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Alcoholism is occasionally complicated by zinc deficiency. We have assessed the possibility that malabsorption of zinc may be a potential cause. Using a dual isotope absorption technique the absorption of ⁶⁵Zn in 18 alcoholic patients was 37% (13 ± SD) and 56% (10 ± SD) in a normal control group (p < 0.001). The mean serum zinc in 55 alcoholic patients was 11.6 μmol/l (3.0 ± SD) and in 36 normal volunteers the mean serum zinc was 13.6μmol/l (1.8 ± SD; p < 0.001). This study suggests that chronic alcohol abuse will decrease the absorption of zinc and this may contribute towards the zinc deficiency occasionally associated with alcoholism.

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Section: Discussioncontrasting

confidence: 55%

Zinc Absorption in Alcoholics Using Zinc-65

Dinsmore¹,

Callender²,

McMaster³

et al. 1985

Digestion

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“…These findings could be explained by the fact that both active alcohol consumption or diuretic use were considered as exclusion criteria in our study. However, inadequate dietary zinc intake and excess urinary zinc loss both ap pear to be contributing factors to explain low plasma or serum zinc values in cirrhotic pa tients [10,22], Whether deranged intestinal absorption of zinc contributes to zinc deple tion is not clear [11,12,23,24].…”

Section: Discussionmentioning

confidence: 99%

“…Low zinc levels have been found in serum, leukocytes, red blood cells, and liver of patients with alcoholic cirrhosis [11,12], This is probably caused by a combination of de creased dietary intake, malabsorption and in creased loss via the gastrointestinal tract and in the urine. Oral zinc supplementation has been used in the management of cirrhotic patients specially in those with encephalopa thy [13].…”

Section: Introductionmentioning

confidence: 99%

Serum Zinc Concentrations in Two Cohorts of 153 Healthy Subjects and 100 Cirrhotic Patients from Mexico City

Poo

Rosas-Romero

Rodriguez

et al. 1995

Dig Dis

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The aim of this study was to assess serum zinc levels in a cohort of healthy subjects and cirrhotic patients from Mexico City. A total of 153 healthy subjects and 100 cirrhotic patients, males and females aged 18-65, were studied. Inclusion criteria for heathy subjects were (1) Mexican-born with first and second generation relatives born in Mexico, and (2) somatometric (body mass index under 30) and clinical evaluation establishing that they had no underlying disease. Entry criteria for cirrhotic patients were (1) clinical and histological proven cirrhosis, (2) compensated liver disease (absence of coma, bleeding hemorrhage or refractory ascitis), and (3) cirrhosis of any cause. Zinc serum levels were measured with atomic absorption spectrophotometry. In healthy subjects, mean serum levels were 77.4 ± 4.2 µg/dl (range 42.9-105.2 µg/dl). In cirrhotic patients zinc serum levels (58.9 ± 16.1 µg/dl, range 22-88 µg/ dl) were significantly lower than in healthy subjects (p < 0.05). A stepwise decline in serum zinc with worsening Child class (A, 73.4 ± 13; B, 64.4 ± 12; C, 55.8 ± 15.6; p < 0.05 by ANOVA test) was found. In conclusion, this study confirms that zinc serum levels are significantly lower in cirrhotic patients and shows that zinc serum levels in a cohort of 153 healthy subjects from Mexico City were unexpectedly lower compared to those found in other countries. This last finding might be explained by different dietetic patterns and deserves further investigation.

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“…It is known to compete with cadmium, copper, lead, iron, and calcium for similar binding sites [14]. Alcoholics are often characterized by hyperzincuria and hypozincemia having increased urinary zinc [15] and decreased serum zinc [16], along with low zinc levels in the body tissue. This derangement of zinc metabolism may be a possible factor responsible for deleterious effects of chronic alcoholism.…”

Section: Introductionmentioning

confidence: 99%

Effect of Zinc Supplementation on the Status of Thyroid Hormones and Na, K, and Ca Levels in Blood Following Ethanol Feeding

Pathak¹,

Dhawan

Pathak

2010

Biol Trace Elem Res

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The influence of zinc (Zn) on the serum levels of triiodothyronine (T(3)), thyroxine (T(4)), thyroid-stimulating hormone (TSH) and sodium (Na), potassium (K), and calcium (Ca) was evaluated following ethanol toxicity to the rats. To achieve this, male Wistar rats (150-195 g) were given 3 ml of 30% ethanol orally, and zinc was given in the form of zinc sulfate (227 mg/l) in their drinking water daily for 8 weeks. Ethanol feeding resulted in a slight decrease in T(3) and T(4) levels and a significant increase in thyroid-stimulating hormone concentration, which may be due to the direct stimulatory effect of ethanol on thyroid. Interestingly, when zinc was given to these rats, all the above levels were brought quite close to their normal levels, thus indicating the positive role of zinc in thyroid hormone metabolism. Serum Zn and Ca levels were found to be reduced, but Na levels were raised upon ethanol feeding. Restoration of normal levels of these metals upon zinc supplementation to ethanol fed rats confirms that zinc has potential in alleviating some of the altered thyroid functions following ethanol administration.

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A Study of Zinc Metabolism in Alcoholic Cirrhosis

Cited by 50 publications

References 0 publications

Zinc Absorption in Alcoholics Using Zinc-65

Zinc Absorption in Alcoholics Using Zinc-65

Serum Zinc Concentrations in Two Cohorts of 153 Healthy Subjects and 100 Cirrhotic Patients from Mexico City

Effect of Zinc Supplementation on the Status of Thyroid Hormones and Na, K, and Ca Levels in Blood Following Ethanol Feeding

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