A study on alkaline heat treated Mg–Ca alloy for the control of the biocorrosion rate

Gu, Xuenan; Zheng, Wei; Cheng, Yan; Zheng, Yufeng

doi:10.1016/j.actbio.2009.01.048

Cited by 215 publications

(101 citation statements)

References 26 publications

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“…Wang et al provide a compact overview of the basic methods available for surface treatment [35]. They hint to microarc oxidation [116], anodising [117], evaporation [118], alkaline heat treatment [119], fluoride coating [120], electro deposition [121], phosphate coating [122], shock peening [123], ion implantation [124], physical vapour enrichment [125] and polymer coating [126]. The aim of the process is always to reduce the oxidation tendency of the surface of the magnesium alloy or to provide the surface with a protective layer.…”

Section: Increasing the Corrosion Resistancementioning

confidence: 99%

Cardiovascular Applications of Magnesium Alloys

Schilling¹,

Bauer²,

LaLonde³

et al. 2017

Magnesium Alloys

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Therapy in cardiovascular medicine often relies on implantation of prosthetic materials or application of stents. The diseases of many cardiovascular structures require their complete and immediate repair by utilising prosthetic materials. The ideal cardiovascular prosthesis involves good functional properties, capability of regeneration and does not activate the host's immune system. Ideally, the graft can be applied for a temporary use and degrades after a predefined period according to controlled degradation kinetics. Only biological grafts would provide this spectrum of properties by today's level of knowledge. However, biological prostheses exhibit some relevant drawbacks as well, such as insufficient mechanical stability or restricted availability. Implants or supporting structures of magnesium alloys would bridge this gap and would either provide a substrate for innovative and temporary grafts or would-as supporting structures-transiently add some missing properties to regenerative biological prostheses. This chapter reviews the different fields of cardiovascular therapeutic applications of magnesium alloys. The required properties of magnesium alloys and their preparation, fabrication and testing will be discussed under the specific cardiovascular perspective.

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Section: Increasing the Corrosion Resistancementioning

confidence: 99%

Cardiovascular Applications of Magnesium Alloys

Schilling¹,

Bauer²,

LaLonde³

et al. 2017

Magnesium Alloys

View full text Add to dashboard Cite

show abstract

“…However, there is a lack of knowledge regarding nanoscale corrosion mechanism and biological evaluation method~Nie & Muddle, 1997; Kim et al, 2008;Li et al, 2008;Gu et al, 2009Gu et al, , 2010!. As biodegradable materials dissolve over the implantation period in the living body, various characterizations are required for biological safety evaluation of medical devices, based on a recently revised ISO 10993-1 guideline.…”

Section: Introductionmentioning

confidence: 99%

Rapid In Vitro Corrosion Induced by Crack-Like Pathway in Biodegradable Mg–10% Ca Alloy

et al. 2013

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Abstract:The in vitro corrosion mechanism of the biodegradable cast Mg-10% Ca binary alloy in Hanks' solution was evaluated through transmission electron microscopy observations. The corrosion behavior depends strongly on the microstructural peculiarity of Mg 2 Ca phase surrounding the island-like primary Mg phase and the fast corrosion induced by the interdiffusion of O and Ca via the Mg 2 Ca phase of lamellar structure. At the corrosion front, we found that a nanosized crack-like pathway was formed along the interface between the Mg 2 Ca phase and the primary Mg phase. Through the crack-like pathway, O and Ca are atomically exchanged each other and then the corroded Mg 2 Ca phase was transformed to Mg oxides. The in vitro corrosion by the exchange of Ca and O at the nanosized pathway led to the rapid bulk corrosion in the Mg-Ca alloys.

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“…The corrosion rate of a treated specimen decreased by ∼83% compared to that of an untreated specimen [66].…”

Section: Alkaline Heat Treatmentmentioning

confidence: 99%

“…This treatment was applied to Mg-Ca specimens, with the process comprising soaking in an alkaline NaHPO 4 solution for 24 h followed by heating at 500˚C for 12 h. This treatment produced a layer with composition of MgNaPO 4 on the surface of the specimen, which serves as a protective layer [66]. The corrosion rate of a treated specimen decreased by ∼83% compared to that of an untreated specimen [66].…”

Section: Alkaline Heat Treatmentmentioning

confidence: 99%

Reduction in the Corrosion Rate of Magnesium and Magnesium Alloy Specimens and Implications for Plain Fully Bioresorbable Coronary Artery Stents: A Review

Lewis¹

2016

WJET

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The most popular treatment/management modality for coronary artery disease, which is one of the leading causes of death, is percutaneous transluminal coronary intervention (popularly known as "plain old balloon angioplasty") followed by implantation of a stent ("stenting"). Stent types have evolved from bare metal stents through first-generation drug-eluting stents to fully bioresorbable stents (FBRSs). Two examples of FBRSs are 1) Mg scaffold with no coating; and 2) Mg alloy scaffold coated with a bioresorbable polymer in which an anti-proliferative drug is embedded. In the case of Mg/Mg alloy FBRSs, one of the reported clinical results is that the resorption time of the stent is too short (<∼4 mo to ∼12 mo), a consequence of the high corrosion rate of the metal/alloy. The present review article contains 1) a summarized but comprehensive comparison and contrast of all the types of stents, with special reference to Mg/Mg alloy FBRSs; 2) a critical review of the body of literature on methods to reduce the corrosion rate of Mg/Mg alloy specimens in various aqueous biosimulating media that may have implications for plain Mg/Mg alloy FBRSs, examples of such methods being alloy chemistry modification and fabrication using a nanocomposite; and 3) directions for future work on Mg/Mg alloy FBRSs that draw upon the findings highlighted in item (2) above as well as on other ideas, such as utilization of a Mg matrix composite and fabrication using a metal additive manufacturing method. Thus, information given in this review may find use in work on decreasing the in vivo resorption time (and, hence, improving the clinical efficacy) of the current generation of fully-bioresorbable Mg/Mg-alloy stents as well as guide the development of the next generation of these stents.

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A study on alkaline heat treated Mg–Ca alloy for the control of the biocorrosion rate

Cited by 215 publications

References 26 publications

Cardiovascular Applications of Magnesium Alloys

Cardiovascular Applications of Magnesium Alloys

Rapid In Vitro Corrosion Induced by Crack-Like Pathway in Biodegradable Mg–10% Ca Alloy

Reduction in the Corrosion Rate of Magnesium and Magnesium Alloy Specimens and Implications for Plain Fully Bioresorbable Coronary Artery Stents: A Review

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