A study on blood lipid profiles, aluminum and mercury levels in college students

Jung, Eunim; Hyun, Wha-Jin; Ro, Yoona; Lee, Hongmie; Song, Kang

doi:10.4162/nrp.2016.10.4.442

Cited by 12 publications

(5 citation statements)

References 20 publications

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“…For Hg exposed rats, the plasma Hg levels, after oral exposure were 35.41 ± 2.60 µg/L which was higher than levels found in several populations. Plasma Hg levels were reported to be an average of 3.08 ± 1.55 µg/L for a Korean male college population (n=43) [31] and 4.6 ± 3.0 µg/L for a larger population of Korean males (n=4283). [32] In an Egyptian population, Hg levels were 4.4 -12.1 µg/L, [28] and in a South African population 0.1 -8.82 µg/L.…”

Section: Resultsmentioning

confidence: 99%

Adverse cardiovascular effects of exposure to cadmium and mercury alone and in combination on the cardiac tissue and aorta of Sprague–Dawley rats

Arbi

Bester

Pretorius

et al. 2021

Journal of Environmental Science and Health, Part A

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The aim of this study was to identify cardiovascular effects of relevant concentrations of Cd and Hg alone and in combination as a mixture in water. This was achieved by administering to male Sprague-Dawley rats via gavage 0.62 mg/kg Cd or 1.23 mg/kg Hg, or a combination of 0.62 mg/kg Cd and 1.23 mg/kg Hg in the co-exposure group for 28 days. Concentrations were the rat equivalence dosages of 1000 times the World Health Organization's limits of 0.003 mg/L and 0.006 mg/L for Cd and Hg respectively, for water. With termination, blood levels of the metals were increased. For all metal exposed groups, histological evaluation and transmission electron microscopy of the myocardium revealed myofibrillar necrosis, increased fibrosis, vacuole formation and mitochondrial damage. Cd caused the most mitochondrial damage while Hg to a greater degree induced fibrosis. In the aorta, both Cd and Hg also increased collagen deposition adversely altering the morphology of the fenestrated elastic fibres in the tunica media. Co-exposure resulted in increased cardiotoxicity with increased mitochondrial damage, fibrosis and distortion of the aortic wall as a result of increased collagen deposition, as well as altered elastin deposition, fragmentation and interlink formation. These are typical features of oxidative damage that correlates with a phenotype of premature ageing of the CVS that potentially can lead to hypertension and premature cardiac failure.

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Section: Resultsmentioning

confidence: 99%

Adverse cardiovascular effects of exposure to cadmium and mercury alone and in combination on the cardiac tissue and aorta of Sprague–Dawley rats

Arbi

Bester

Pretorius

et al. 2021

Journal of Environmental Science and Health, Part A

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“…The GM of blood Al was 10.57 μg/L, with no significant difference between men and women and no age dependence. A previous study reported that the GM of blood Al was 8.61 μg/L for college students in Korea [ 22 ]. However, blood Al levels measured here, were considerably higher than those reported in France (2.32 μg/L) [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Determination of Trace Metal Levels in the General Population of Korea

Kim

Lim

Lee

et al. 2017

IJERPH

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The purpose of this study was to determine the levels of trace metals in the blood of the general Korean population. A total of 258 healthy individuals, according to their regular medical check-ups, (119 males and 139 females, age ranging from 12 to 78 years old) were enrolled from December 2014 to December 2016. Levels of 10 trace elements were determined using inductively coupled plasma mass spectrometry (ICP-MS). The geometric mean (GM) levels for lead, arsenic, cesium, mercury, aluminum, cadmium, copper, manganese, selenium, and zinc were 15.97 μg/L, 7.19 μg/L, 2.39 μg/L, 3.41 μg/L, 10.57 μg/L, 0.78 μg/L, 979.8 μg/L, 11.06 μg/L, 111.37 μg/L, and 872.7 μg/L, respectively. There were significant gender-related differences in the levels of several metals; male individuals had higher Pb, As, Cs, Hg, and Se than females, while females had higher Cd, Cu, and Mn than males. We noticed remarkably high blood levels of Hg, As and Al in the Korean population. The element concentrations reported represent a new contribution to the knowledge of the blood chemistry for the Korea population. The data can be used to assess the clinical health of this population.

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“…Acute and chronic exposure to aluminum chloride (AlCl 3 ) produced dyslipidemic changes, showing a significant increase in total cholesterol (TC), TG, and LDL with decreased HDL and a decrease in TC/HDL and LDL/HDL ratios. [ 7 8 9 ] College-going male students reported an incidence of dyslipidemia linked with increased Al levels in their blood. [ 8 ] A specific dyslipidemic pattern has been linked to the hormonal changes associated with menopause.…”

Section: Introductionmentioning

confidence: 99%

“…[ 7 8 9 ] College-going male students reported an incidence of dyslipidemia linked with increased Al levels in their blood. [ 8 ] A specific dyslipidemic pattern has been linked to the hormonal changes associated with menopause. These are accountable for cardiovascular deaths and associated complications linked with disrupted estrogenic activity.…”

Section: Introductionmentioning

confidence: 99%

Aluminum as a Possible Cause Toward Dyslipidemia

Sengupta

Gaur

Nayak

et al. 2023

Indian Journal of Occupational and Environmental Medicine

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Aluminum, the third most abundant metal present in the earth’s crust, is present almost in all daily commodities we use, and exposure to it is unavoidable. The interference of aluminum with various biochemical reactions in the body leads to detrimental health effects, out of which aluminum-induced neurodegeneration is widely studied. However, the effect of aluminum in causing dyslipidemia cannot be neglected. Dyslipidemia is a global health problem, which commences to the cosmic of non-communicable diseases. The interference of aluminum with various iron-dependent enzymatic activities in the tri-carboxylic acid cycle and electron transport chain results in decreased production of mitochondrial adenosine tri-phosphate. This ultimately contributes to oxidative stress and iron-mediated lipid peroxidation. This mitochondrial dysfunction along with modulation of α-ketoglutarate and L-carnitine perturbs lipid metabolism, leading to the atypical accumulation of lipids and dyslipidemia. Respiratory chain disruption because of the accumulation of reduced nicotinamide adenine di-nucleotide as a consequence of oxidative stress and the stimulatory effect of aluminum exposure on glycolysis causes many health issues including fat accumulation, obesity, and other hepatic disorders. One major factor contributing to dyslipidemia and enhanced pro-inflammatory responses is estrogen. Aluminum, being a metalloestrogen, modulates estrogen receptors, and in this world of industrialization and urbanization, we could corner down to metals, particularly aluminum, in the development of dyslipidemia. As per PRISMA guidelines, we did a literature search in four medical databases to give a holistic view of the possible link between aluminum exposure and various biochemical events leading to dyslipidemia.

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A study on blood lipid profiles, aluminum and mercury levels in college students

Cited by 12 publications

References 20 publications

Adverse cardiovascular effects of exposure to cadmium and mercury alone and in combination on the cardiac tissue and aorta of Sprague–Dawley rats

Adverse cardiovascular effects of exposure to cadmium and mercury alone and in combination on the cardiac tissue and aorta of Sprague–Dawley rats

Determination of Trace Metal Levels in the General Population of Korea

Aluminum as a Possible Cause Toward Dyslipidemia

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