A Study on Flavonoids of Propolis

Bankova, Vassya; Попов, Симеон; Мареков, Н.

doi:10.1021/np50028a007

Cited by 131 publications

(75 citation statements)

References 8 publications

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“…The annexin V assay revealed apoptotic cells exposed to EEP (Figure 2). The major active components of propolis are flavonoids and phenolic acids present in EEP at the levels of 25-30%; they have many biological and pharmacological activities including immunopotentiation and antitumor effects [8,9,10,13,21].…”

Section: Resultsmentioning

confidence: 99%

Ethanolic Extract of Propolis (EEP) Enhances the Apoptosis- Inducing Potential of TRAIL in Cancer Cells

et al. 2009

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Ethanolic extract of propolis (EEP) is one of the richest sources of phenolic acids and flavonoids. EEP and its phenolic compounds have been known for various biological activities including immunopotentiation, chemopreventive and antitumor effects. Tumor necrosis factor related apoptosis inducing ligand (TRAIL) is a naturally occurring anticancer agent that preferentially induces apoptosis in cancer cells and is not toxic toward normal cells. We examined the cytotoxic and apoptotic effect of EEP and phenolic compounds identified in propolis in combination with TRAIL on HeLa cancer cells. HeLa cells were resistant to TRAIL-induced apoptosis. Our study demonstrated that EEP and its components significantly sensitize to TRAIL induced death in cancer cells. The percentage of the apoptotic cell after exposure to 50 μg/mL EEP and 100 ng/mL TRAIL increased to 71.10±1.16%. The strongest cytotoxic effect in combination with TRAIL on HeLa cells exhibited apigenin and CAPE at the concentration of 50 μM (58.87±0.75% and 49.59±0.39%, respectively). In this report, we show for the first time that EEP markedly augmented TRAIL mediated apoptosis in cancer cells and confirmed the importance of propolis in chemoprevention of malignant tumors.

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Section: Resultsmentioning

confidence: 99%

Ethanolic Extract of Propolis (EEP) Enhances the Apoptosis- Inducing Potential of TRAIL in Cancer Cells

et al. 2009

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“…In addition to collecting nectar and pollen, foragers can collect plant gum (propolis) and water (Fanesi et al, 2009;Marcucci, 1995;Bankova et al, 1983Bankova et al, , 2000.…”

Section: Honeybee Foraging Behaviormentioning

confidence: 99%

“…In some countries, and especially in Eastern Europe, propolis has been used in folk medicine for centuries. Its chemical composition includes flavonoids, aromatic acids, esters, aldehydes, ketones, fatty acids, terpenes, steroids, amino acids, polysaccharides, hydrocarbons, alcohols, hydroxybenzene, and several other compounds (Marcucci, 1995;Bankova et al, 1983Bankova et al, , 2000 which varies according to the plants in a specific region. The flavonoids (mainly pinocembrin) are considered to be responsible for its inhibitory effect on bacterial and fungus, but only traces of these compounds have been found in propolis of South American origin (Tomás-Barberán et al, 1993).…”

Section: Honeybee Foraging Behaviormentioning

confidence: 99%

Honeybee Communication and Pollination

Suwannapong¹,

Eiri²,

Benbow³

2012

New Perspectives in Plant Protection

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“…interestingly, Bulgarian propolis is the most studied Bulgarian bee product. there are detailed reports on its chemical composition (4,5,7) and its plant origin from the bud exudates of the black poplar Populus nigra has been proved unambiguously. Many research groups have found evidence for the diverse biological activities of Bulgarian propolis.…”

Section: Bulgarian Propolismentioning

confidence: 99%