A Study on Hematological Abnormalities in Chronic Liver Diseases

T, Rajkumar Solomon; Aravind, A.; K, Caroline Selvi; Balamurali, R.; Ramkumar, G.; Muthukumuran, K; C, Vaishnavipriyaa; Kavitha, S.; Anand, Anil C.; Joeimon, J L; Mohanraj, Karthik Ganesh; Rk, Karthikeyan; J, Kayalvizhi

doi:10.9790/0853-1606143844

Cited by 11 publications

(9 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study, the data revealed that the mean values of RBCs, Hb, Hct, WBCs and PLATS counts and concentration were significantly decreased in group treated with DEN when compared with their corresponding levels in the control group (p< 0.05) so this case called pancytopenia while there was no statistically significant difference in the mean values of blood indices in rats treated with DEN when compared with their corresponding levels in the control group. These results in agreed with (Carr, 2016 ;Selvamani and Thomas, 2017) who stated that decreased RBCs and hemoglobin most common anemia in primary HCC patients and often its type is normochromic normocytic anemia as inferred from the study leucopenia and thrombocytopenia are present in most patients and is commonly present in the patients with splenomegaly and with the history of bleeding tendencies, also these results agreed with (Solomon et al, 2017) who showed the Study on hematological abnormalities in chronic liver diseases and this might be due to the direct damage of the bone marrow and the blood elements are sensitive to the oxidative stress and their plasma membranes contain a highly percentage of polyunsaturated fatty acids (Carr, 2016) and this increases lipid peroxidation products. On the other hand (Nilakanth and Balachandran, 2019) revealed that curcumin treatment could decrease or mitigate the toxic effects of anemia and leukocytosis against DEN induced toxicity.…”

Section: Discussionsupporting

confidence: 88%

Hematological and Biochemical Changes in Rats Induced With Diethyl Nitrosamine and the Hepatoprotective Role of Some Antioxidants

Zaahkouk

Mehany

El-Shamy

et al. 2019

Egyptian Academic Journal of Biological Sciences, B. Zoology

View full text Add to dashboard Cite

Hepatocellular carcinoma is one of the most common malignancies worldwide and in Egypt the most common form of primary liver cancer. HCC represents the second most prevalent cancer among men in Egypt. The important risk factors for HCC include hepatitis C and B, alcoholic, schistosomiasis, aflatoxins (AFB), hypothirodism and cirrhosis. Diethyl nitrosamine (DEN) is a well-known strong hepatocarcinogenic agent. It is known that DEN induces damage in enzymes involved in DNA repair and is normally used to induce liver cancer in experimental animal models as rats. Curcumin is a strong antiinflammatory agent and anti-cancer effects with strong therapeutic potential against a variety of cancers. Vitamin C is an important free radical scavenger in extracellular fluids, trapping radicals and protecting bio membranes from peroxide damage and tissue damage of the liver and in HCC cases. Objective: To evaluate the hematological parameters and some liver function tests in the early stage of HCC and the hepatoprotective role of curcumin and vitamin C.Materials and methods: This study was conducted on a patch of 90 adult mature healthy male albino rats (Rattus rattus) averaged weight (190 ± 10 g) were allowed to acclimatize in the laboratory and distributed into 9 groups 10 rats for each. Hematological parameters and some hepatic tests were measured and histopathology of the liver, for all groups at the end of the experiment.Results: The results showed that significant alterations in all hematological parameters and hepatic function tests when compared with its corresponding level in the control group, and when treated with curcumin and vitamin c the results showed improvement for some parameters when compared with DEN group. Conclusion: Antioxidants like curcumin and vitamin C administration improved the hematological parameters and liver function tests.

show abstract

Section: Discussionsupporting

confidence: 88%

Hematological and Biochemical Changes in Rats Induced With Diethyl Nitrosamine and the Hepatoprotective Role of Some Antioxidants

Zaahkouk

Mehany

El-Shamy

et al. 2019

Egyptian Academic Journal of Biological Sciences, B. Zoology

View full text Add to dashboard Cite

show abstract

“…27 Also, the present study reported deteriorations in HCC patient's F I G U R E 3 Sensitivity and specificity of the studied genes (NBAT-1 and FOXCUT) in differentiating between different groups deteriorated liver functions, increased serum AFP and kidney functions parameters impairments were common laboratory findings in chronic liver diseases involving HCC. 26,[28][29][30] Concerning the first question in this study, it was found that there was a significant higher expression of NBAT-1 (median…”

Section: Discussionmentioning

confidence: 64%

“…Also, the present study reported deteriorations in HCC patient's laboratory data including CBC pictures (anemia, leucopenia, and thrombocytopenia), liver function tests (high liver enzymes: AST, ALT, ALP, and GGT, high total and direct bilirubin, low PC, prolonged PT, and INR) kidney function tests (high urea), and high serum AFP when compared to those for HCV patients or normal values. Previous studies demonstrated that pancytopenia, deteriorated liver functions, increased serum AFP and kidney functions parameters impairments were common laboratory findings in chronic liver diseases involving HCC 26,28–30 …”

Section: Discussionmentioning

confidence: 98%

Serum lncRNAs, NBAT‐1, and FOXCUT signature in hepatocellular carcinoma developed on top of chronic hepatitis C

Ali

Shaker

Ezzat

et al. 2022

Molecular Carcinogenesis

View full text Add to dashboard Cite

Background: Hepatocellular Carcinoma (HCC) is a universal health problem responsible for 8.2% of all cancer deaths. Numerous risk factors were documented to be contributed to HCC development with viral hepatitis C ranking as the major predisposing factor in Egypt. The presence of a detectable amount of long noncoding RNAs (lncRNAs) in the circulation is linked to the development and spread of tumors.LncRNAs NBAT-1 and FOXCUT expression levels were used as genetic markers for the detection of gastrointestinal tract cancers. We hypothesized that serum expression levels of NBAT-1 and FOXCUT are new biomarkers for HCC that are related to laboratory and pathological markers. Patients and Methods: This study included 165 hepatitis C virus (HCV)-related HCC Egyptian patients, 180 HCV-infected noncancer patients, and 180 healthy controls, the serum expression levels of NBAT-1 and FOXCUT were measured by using quantitative real-time polymerase chain reaction. Results: This study's results include that medians (inter-quartile range [IQRs]) of NBAT-1 in HCC and HCV patients were (1.

show abstract

“…Moreover, leucopenia and thrombocytopenia observed in this study are present in patients with splenomegaly and with a history of bleeding tendencies. The abnormalities of hematological parameters in chronic liver diseases are cross-linked to the damage of bone marrow, and plasma membranes contain high levels of prooxidant products [ 79 , 80 ]. In opposite, G. resinaceum polysaccharide-rich fractions increased WBCs, lymphocytes count, and hematocrit, meaning that they could mitigate or attenuate the harmful effects of anemia and leukocytosis against DEN intoxication.…”

Section: Discussionmentioning

confidence: 99%

Polysaccharide-Rich Fractions from Ganoderma resinaceum (Ganodermataceae) as Chemopreventive Agents in N-Diethylnitrosamine-Induced Hepatocellular Carcinoma in Wistar Rats

Sipping

Kengne

Kenmogne

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is one of the most common and lethal diseases worldwide. Its treatment remains ineffective and the prognosis remains severe, thus favoring the emergence of a preventive approach. Mushroom-derived polysaccharides offer great opportunities because of their less toxicity and bioactivities. The present study aimed to investigate the chemopreventive effects of water-soluble polysaccharides from Ganoderma resinaceum on HCC. Two G. resinaceum polysaccharide-rich fractions (GRP I and GRP II) were obtained following hot water and alcohol precipitation. Their proteins, phenol compounds, and total neutral sugar content were assayed. The in vitro antiproliferative effect was assessed in MDA-MB 231, Hela, and HepG2 using the MTT assay. Further, for the in vivo study, seven groups of nine rats each received N-diethylnitrosamine (100 mg/kg BW), vehicle (NaCl 0.9%), doxorubicin (10 mg/kg BW), or G. resinaceum polysaccharides (125 and 250 mg/kg BW). Liver cancer initiation and progression was assessed by evaluating histomorphology of liver section, hepatic injury markers, hematology, cytokines/chemokines levels, and stress oxidative markers. GRP II presented higher protein and sugar and lower phenol compound content than GRP I. GRP exhibited CC50 of 340 and 261.7 in HepG2 cells after 48 h. Moreover, GRP I and GRP II (125 and 250 mg/kg) prevented the alteration of the histoarchitecture of the liver induced by the DEN. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alpha-fetoprotein (AFP), proinflammatory cytokines (G-CSF, IFNγ, and TNFα), and chemokines (eotaxin and fractalkine) levels were significantly decreased in the GRP I- and GRP II-treated groups, while anti-inflammatory cytokines (IL-10 and IL-12p70) levels were increased. The antioxidant defense was also stimulated by reducing malondialdehyde (MDA) and nitric oxide (NO2) levels, increasing catalase (CAT) and superoxide dismutase (SOD) activities, and reducing glutathione (GSH) levels. Our results indicate that GRP I exhibits chemopreventive effects by inhibiting cell proliferation and restoring liver architecture, antioxidant enzymes, and cytokines/chemokines balance.

show abstract

A Study on Hematological Abnormalities in Chronic Liver Diseases

Cited by 11 publications

References 1 publication

Hematological and Biochemical Changes in Rats Induced With Diethyl Nitrosamine and the Hepatoprotective Role of Some Antioxidants

Hematological and Biochemical Changes in Rats Induced With Diethyl Nitrosamine and the Hepatoprotective Role of Some Antioxidants

Serum lncRNAs, NBAT‐1, and FOXCUT signature in hepatocellular carcinoma developed on top of chronic hepatitis C

Polysaccharide-Rich Fractions from Ganoderma resinaceum (Ganodermataceae) as Chemopreventive Agents in N-Diethylnitrosamine-Induced Hepatocellular Carcinoma in Wistar Rats

Contact Info

Product

Resources

About