A study on histopathological changes in lesions of vitiligo in Karnataka population

Abstract

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Vitiligo is considered to be symptom less and its presentation is boundless varying from isolated focal lesion to bizarre generalized lesions. The present study was undertaken to study the histopathological changes in lesions of vitiligo in south Indian population.</span></p><p class="abstract"><strong>Methods:</strong> 150 patients with mild to moderate vitiligo features attending the outpatient department of Dermatology, Venereology and Leprology at Chitageri General Hospital and Bapuji Hospital attached to J.J.M Medical College, Davengere were utilized to study the histopathological features in vitiligo and its association with other diseases.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Destruction of melanocytes at dermo-epidermal junction was noted. We have observed presence of melanocytes in the basal layer of the epidermis on left side of the lesion, whereas decreased melanocytes in the basal layer of the epidermis on the right side of the same lesion in the present study. Dermis with mild perivascular lymphocytic infiltration and acanthosis along with mono nuclear cell infiltration in the upper dermis was observed. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">The present study gives better knowledge to the clinicians about the lesions of vitiligo and its pathogenesis.</span></p>

A study to compare clinico-histopathological and dermoscopic findings in patients of vitiligo

“…In current study, on histopathology, hyperkeratosis of epidermis was observed in 52% which was found significant statistically(p=0.018) concordant to the study done by Verma et al (63.3%) but discordant with Nagaral GV et al (13.3%), similarly lymphocytic infiltration was 86% in our study which was similar to Sharquie KE et al (80%) but different from Nagaral et al (37.7%). [17][18][19] Also absence of melanocytes was 78% in our study which was also significant statistically (p=0.048) compared to 52% in Nagaral et al and presence of melanocytes (mild) was 44% in contrast to 13.3% of Nagaral et al 19 Dermoscopy is a non-invasive technique helping the doctor diagnoses vitiligo at an early stage and to label it as stable or unstable. In our study we found various findings which were both concordant and discordant with several studies (Table 2).…”

Clinical and Histopathological Study in Vitiligo Patients

“…In our study, Perivascular inflammation was among majority (71.2%) of patients. According to Nagaral and Karibasappa (2017) 31 observed dermis with mild perivascular lymphocytic infiltration and acanthosis along with mono nuclear cell infiltration in the upper dermis.Similar to our study, Alikhan A et al(2011) 2 reported perivascular inflammatory infiltrate in 30% of cases in a review of 74 vitiligo specimens. In our study, Lichenoid inflammation was among more than one third of patients (19.2%).Attili and Attili (2013) 32 found that focal lichenoid inflammation of varying degrees around epidermal/adnexal melanocytes was identified as a common feature in evolving lesions of both SV (segmental vitiligo) (78%) and GV (Generalised vitiligo) (70%).…”

<p>Does the Autophagy Related Gene 7 (ATG7) Have a Role in Non-Melanoma Skin Cancer?</p>

“…From each block, several 5 micron (5 µm) thick sections were taken and stained with hematoxylin and eosin (H&E) stain for the routine histopathologic evaluation. 16 Sections on positive charged slides were immune histochemical (IHC) stained of ATG7. Assessment of ATG7 IHC stained slides in both epithelium and stroma (as staining state: either positive or negative, staining localization.…”