&lt;p&gt;Does the Autophagy Related Gene 7 (ATG7) Have a Role in Non-Melanoma Skin Cancer?&lt;/p&gt;

Samaka, Rehab Monir; Basha, Mohamed Ahmed; Mansour, E. Hani

doi:10.2147/ccid.s222051

Cited by 3 publications

(2 citation statements)

References 38 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous investigations have indicated that oncogenic lncRNAs that function as ceRNAs are required for promoting autophagy in HCC. For example, autophagy-related genes 3, 5, 7, and 12 ( ATG3 , ATG5 , ATG7 , and ATG12 , respectively) are major regulators of the induction of autophagosome formation[ 41 - 43 ]. The lncRNA PVT1 promotes autophagy in HCC by enhancing ATG3 expression by sponging miR-365[ 44 ].…”

Section: Role Of Lncrnas As Cernas In Hccmentioning

confidence: 99%

Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma

Niu¹,

Wang²,

Dong³

et al. 2020

WJG

View full text Add to dashboard Cite

Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) are noncoding RNAs (ncRNAs) that occupy over 90% of the human genome, and their main function is to directly or indirectly regulate messenger RNA (mRNA) expression and participate in the tumorigenesis and progression of malignances. In particular, some lncRNAs can interact with miRNAs as competing endogenous RNAs (ceRNAs) to modulate mRNA expression. Accordingly, these RNA molecules are interrelated and coordinate to form a dynamic lncRNA-mediated ceRNA regulatory network. Mounting evidence has revealed that lncRNAs that act as ceRNAs are closely related to tumorigenesis. To date, numerous studies have established many different regulatory networks in hepatocellular carcinoma (HCC), and perturbations in these ceRNA interactions may result in the initiation and progression of HCC. Herein, we emphasize recent advances concerning the biological function of lncRNAs as ceRNAs in HCC, with the aim of elucidating the molecular mechanism underlying these HCC-related RNA molecules and providing novel insights into the diagnosis and treatment of HCC.

show abstract

Section: Role Of Lncrnas As Cernas In Hccmentioning

confidence: 99%

Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma

Niu¹,

Wang²,

Dong³

et al. 2020

WJG

View full text Add to dashboard Cite

show abstract

“…On a common level, autophagy shows up basic to preserve both cellular homeostasis (through the expulsion of harmed protein and organelles) and giving a survival component for cells amid a push [4] . Subsequently, autophagy is associated with different pathologies, such as cancer, neurodegenerative disease, and inflammatory bowel disorders [5] . The skin serves as the primary line of defense against numerous distinctive environmental insults; however, the impact of autophagy on the pathogenesis of skin disorders was not adequately studied [6] .…”

Section: Introductionmentioning

confidence: 99%

Autophagy in non-neoplastic skin diseases

Amer¹,

Samaka

Moftah

2020

Journal of Recent Advances in Medicine

View full text Add to dashboard Cite

Background: Autophagy is an essential cellular mechanism that plays the "housekeeping" role in normal physiological processes, including the removal of long-lived, harvested, and misfolded proteins, damaged organs. On the other hand, under conditions causing cellular stress, such as malnutrition, hypoxia, oxidative stress, pathogen infections, radiation or cancer medication, there is an increase in the degree of autophagy, which leads to adaptation and cell survival. With the current interest in autophagy, this process appears to affect every organ and modify growing list of disease processes. The skin acts as the first line of defense against different environmental stresses; However, only a few studies have investigated the effect of autophagy on the pathogenesis of skin diseases. The level of autophagy may reflect the degree of some diseases; Therefore, detecting the level of autophagy may be an indirect means to assess some diseases.Objective: to provides an overview of recent findings relevant to the role of autophagy in non-neoplastic skin diseases. Conclusion:Autophagy plays an important role in mitigating or exacerbating various skin diseases. Understanding the mechanisms of autophagy and their regulation in different tissues and cells under healthy and stressful conditions will help better understand the etiology of skin diseases and develop more effective therapeutic approaches.

show abstract