A Study on Immonium Ions and Immonium-Related Ions Depending on Different Collision Energies as Assessed by Q-TOF MS

Cheng, Guo; Guo, Xue-Feng; Zhao, Lei; Chen, D. D.; Wang, J.; Sun, Jia

doi:10.1134/s1068162018040088

Cited by 1 publication

(1 citation statement)

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“…Chemical pesticides are the principal method of pest control. New pesticides often perform well when they are just put into use, but with the emergence of pest resistance, the effect of drug use will fall precipitously [3] . Finding new targets and developing new pesticides have become an important ways to deal with resistance [4]…”

Section: Introductionmentioning

confidence: 99%

Synthesis, and Insecticidal Activities of Propargyloxy‐Diphenyl Oxide‐Sulfonamide Derivatives

Wang,

Guo,

Zhou

et al. 2024

Chemistry & Biodiversity

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Agricultural pests are the primary contributing factor to crop yield reduction, particularly in underdeveloped regions. Despite the significant efficacy of pesticides in pest control, their extensive use has led to the drug‐fast of insecticide resistance. Developing of new environmentally friendly plant‐based pesticides is an urgent necessity. In this study, a series of diaryl ether compounds containing propargyloxy and sulfonamide groups were designed. The synthesis of these 36 compounds primarily relied on nuclear magnetic resonance for structure determination, while single‐crystal X‐ray diffraction was employed for certain compounds. Meanwhile, the insecticidal activities against Mythimna separata were also assessed. Some of the compounds exhibited significantly enhanced activity, the LC50 value of the highest activity compound TD8 (0.231 mg/mL) demonstrating respective increases by 100‐fold compared to the plant pesticide celangulin V (23.9 mg/mL), and a 5‐fold increase with the positive control L‐1 (1.261 mg/mL). The interaction between the target compound and the target, as well as the consistency of the target, were verified through symptomological analysis and molecular docking. The structure‐activity relationships were also conducted. This study offered a novel trajectory for the advancement and formulation of future pesticides.

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Section: Introductionmentioning

confidence: 99%