Automobile panel moulds are assembled pieces with various surface features, making it difficult to predict the machining properties in ball-end milling process. In this paper, Deform 3D finite element analysis software is used to simulate the ball-end milling of multi-hardness assembled moulds, and to analyse the distribution patterns of milling forces, stress fields and temperature fields in the transition regions of the multi-hardness assembled moulds. Subsequently, milling of sine surface moulds is simulated, and the effects of milling parameters on the thermal performance of sine surfaces are analysed. Finally, the multi-hardness assembling and milling experiment and the sine surface mould milling experiments are conducted to verify the effectiveness of the Deform 3D finite element simulation method.