Mobile wireless sensor networks (MWSNs) have emerged and shifted the focus from the typical static wireless sensor networks to networks with mobile sensor nodes that are capable to sense the various types of events. Also, they can change their position frequently in a specific sensing area. The applications of the MWSNs can be widely divided into time-driven, event-driven, on-demand and tracking based applications. Mobile sensor node architecture, residual energy utilization, mobility, topology, scalability, localization, data collection routing, Quality of Service (QoS), etc., are the key factors to design an energy efficient MWSNs for some specific purpose. This chapter deals with an overview of the MWSNs and a few significant phenomena to design an energy efficient MWSNs to the large-scale environment.