Abstract:Advances in imaging technologies and imaging probes for in situ and real-time visualization of important analytes and biological events humans are now extending the applications of imaging further into drug...
“…On the other hand, developing fluorescent and bio-activated small molecules is a potential strategy for cancer theranostics and research into novel drugs, which could monitor the enzyme activity level by fluorescence response and regulate the bio-activity of the cancer enzyme involved by the molecular activity mechanism. 109–114 Last but not least, the ultimate thrust of this research should be on clinical applications of these probes in imaging, diagnosis, and drug delivery systems based on the basic knowledge acquired from these studies.…”
The work reports the progress of small-fluorescent molecules for bioimaging applications to cancer-relevant biomarkers H+, NO, H2S and reactive oxygen species (H2O2, HClO, O2˙−, 1O2 and ˙OH) over the past six years.
“…On the other hand, developing fluorescent and bio-activated small molecules is a potential strategy for cancer theranostics and research into novel drugs, which could monitor the enzyme activity level by fluorescence response and regulate the bio-activity of the cancer enzyme involved by the molecular activity mechanism. 109–114 Last but not least, the ultimate thrust of this research should be on clinical applications of these probes in imaging, diagnosis, and drug delivery systems based on the basic knowledge acquired from these studies.…”
The work reports the progress of small-fluorescent molecules for bioimaging applications to cancer-relevant biomarkers H+, NO, H2S and reactive oxygen species (H2O2, HClO, O2˙−, 1O2 and ˙OH) over the past six years.
“…6) with bright green fluorescence in HeLa cells. 185 In another work, we systematically studied the molecular properties of two marketed drugs ( alectinib and rilpivirine ) (Fig. 6) and further explored their photophysical luminous mechanisms, which provided a more theoretical basis for traceable drugs and promoted the development of integrated diagnosis and treatment.…”
Section: Conclusion and Future Perspectivesmentioning
Endometrial cancer (EC) is a common malignancy among women worldwide, and recurrence makes it a common cause of cancer-related death. Surgery and external radiation, chemotherapy, or a combination of strategies...
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