The COVID-19 pandemic has caused overwhelming levels of medical waste, resulting in constant threats to environmental pollution. Furthermore, many environmental issues related to medical waste have emerged. This study aims to propose an application that allows the identification and classification of hospitals that generate overwhelming levels of medical waste aftermath of the COVID-19 pandemic by using Multi-Criteria Decision-Making methods (MCDM). MCDM was designed on the integration of the Analytic Hierarchy Process (AHP), linear diophantine fuzzy set-fuzzy decision by opinion score method (LDFN-FDOSM), and Artificial Neural Network (ANN) analysis. Ten hospital managers were interviewed to determine the volume of medical waste generated by the hospitals they manage. Five types of medical waste were identified: general waste, sharps waste, pharmaceutical waste, infectious waste, and pathological waste. Among these five types, pharmaceutical waste is appointed as one that most impacts the environment. After that 313 experts in the health sector with experience in sustainability techniques were targeted to determine the best and worst technique for the Circular Economy to manage medical waste using the neural network approach. Findings also revealed that incineration technique, microwave technique, pyrolysis technique, autoclave chemical technique, vaporised hydrogen peroxide, dry heat, ozone, and ultraviolet light were the most vital and effective methods to dispose of medical waste during the pandemic. Additionally, ozone was ranked first as the most Circular Economy-related method for medical waste disposal. Among the implications of this study for governments, policymakers, and practitioners identify actions that hospitals may consider regarding the Circular Economy concept. Another implication is the supportive role of policymakers in transitioning most pollutant hospitals to becoming more sustainable.