A Study on surgical Site Infections, their bacteriological profile and antimicrobial susceptibility pattern

Pradeep, M.S.S.; Rao, K Vishnu Vardhana

doi:10.18231/2581-4761.2019.0003

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…All the bacteria tested were absolutely resistant (100%) to Metronidazole which is one of the most commonly used over-the-counter drug, and more than a half of the bacterial isolates tested were also absolutely resistant to Cefuroxime and Amoxicillin/Clavulanate. Similar findings were reported by Kemebradikumo [27], where absolute resistance (100%) to Amoxicillin/Clavulanate was found. Majority of the bacterial isolates tested were found to be resistant to 6 of the antimicrobial agents with nine different resistant patterns of antibiotics resistance.…”

Section: Discussionsupporting

confidence: 90%

Incidence, Antibiotic Susceptibility Pattern and Plasmid Profile of Bacterial Pathogens from Surgical site Infections in a Tertiary Hospital in Lagos, Nigeria

2023

PSMPH

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Surgical site infections [SSIs] remain a common postoperative complication despite the use of prophylactic antibiotics and other preventive measures, mainly due to increasing antimicrobial resistance. SSIs increase postoperative morbidity and mortality and may require hospital admission, intravenous antibiotics and even surgical re-intervention. A hospital based descriptive study was conducted on 100 consented postoperative patients with clinical SSIs.Data on patients was obtained using structured data collection form. Swab samples were collected aseptically from each patients. Bacteriological culture examination and identification was done following standard microbiological techniques. Antibiotics sensitivity test was done by Kirby-Bauer disc diffusion method. Ninety (90%) bacterial isolates were recovered from surgical site infection. Gram negative bacteria (GNB) were predominant (83.3%) with the dominant being Escherichia coli (27.78%) and Staphylococus aureus (16.67%). All the isolates were highly resistant to amoxicillin/clavunalate, ceftazidime, cefuroxime, levofloxacin and all the isolates were resistant to metronidazole but susceptible to imipenem, polymycin B and amikacin. The plasmid analysis in this study revealed that out of the 40 (44.4%) multi-drug resistance isolates, 35 (87.5%) of which were Gram-negative bacteria had 9 (22.5%) detectable plasmid pattern with the molecular weight of between 2027kbp to 23120kbp while the remaining 26 (74.6%) had no plasmid bands. The remaining 5 (12.3%) which was Staphylococcus aureus isolates had 2 (40%) detectable plasmid pattern with the molecular weight of between 23130kbp and 6557 while the remaining 3 (60%) had no plasmid bands. Imipenem is the drug of choice in the treat-PriMera Scientific Medicine and Public Health https://primerascientific.com/psmph Incidence, Antibiotic Susceptibility Pattern and Plasmid Profile of Bacterial Pathogens from Surgical site Infections in a Tertiary Hospital in Lagos, Nigeria 24 ment of surgical site infections in this study area These findings necessitates judicious antibiotic use and calls for surveillance of SSIs periodically as well as strict adherence to good sanitation practice to reduce spread of drug-resistant pathogens.

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Section: Discussionsupporting

confidence: 90%

Incidence, Antibiotic Susceptibility Pattern and Plasmid Profile of Bacterial Pathogens from Surgical site Infections in a Tertiary Hospital in Lagos, Nigeria

2023

PSMPH

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“…In our study majority causative microorganisms were Gram-negative bacilli (75.21%) and rest were Grampositive cocci (24.79%). Previously Bhattacharya S et al 14 showed MRSA as the major pathogen of SSI but recent studies by Deka S et al 15 and Pradeep MS et al 30 established Gram-negative bacilli as predominant pathogens of SSI.…”

Section: Majority Of Ssi Cases In the Caesareanmentioning

confidence: 99%

A study on clinico-demographic and microbiological profile of surgical site infection (SSI) in a tertiary care hospital, Kolkata: An alarming trend

Ganguly-Bhattacharjee,

Banik,

Haldar

et al. 2024

IJMR

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The Centres for Disease Control and Prevention (CDC) estimates surgical site infections SSI is major contributor of healthcare associated infections (HAI). Multidrug resistant (MDR) Gram-negative bacilli are emerging pathogens. This study aimed to determine the magnitude of SSI and identify predominant pathogens with their antimicrobial susceptibility patterns. It is a hospital-based descriptive cross-sectional study including 2070 suspected SSI specimens from 25809 surgeries between 1July 2021 to 30 June 2023. Organisms’ identification and AST was done by both conventional and automated methods. Data was collected and analysed on MS-Excel sheet with various charts and tables. In our study SSI rate was 6.3%, much higher than previous study (2.83%) from this institution. SSI rate was highest in plastic surgery (8.2%). Major pathogens of SSI were Gram-negative bacilli e.g., (26.34%), (25.59%) and (74.69%) was predominant among Gram-positive cocci. Gram-negative bacilli including enterobacterales and non-fermenter and showed resistance to major classes of broad- spectrum antibiotics. Methicillin resistance (MRSA) was 43.9%, which indicates need to improve infection control practices. Our study showed significant higher proportion of SSI as compared to previous studies from the same institute with alarming number of isolated MDR Gram-negative bacilli. So, this study focusses the need of robust infection control practices and strict implementation of antimicrobial stewardship to overcome challenges of antimicrobial resistance.

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Bacteriological profile of surgical site infections and their antimicrobial susceptibility pattern at a tertiary care hospital, Western Gujarat

Mehta,

Patel,

Shingala

2024

IJMMTD

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Surgical site infection (SSI) is a frequently occurring repercussion of surgery. It results in mortality and morbidity post-surgery. The present study aims to isolate the organisms causing SSI and determine the antimicrobial susceptibility patterns of the isolates.A total of 250 patient samples were included in the study, their demographic details obtained and processed as per Standard Microbiological Protocols. Antibiotic susceptibity of the positive cultures was performed using Modified Kirby-Bauer disc diffusion method. Out of the 250 samples, 102 (40.8%) samples showed positive culture growth. Positivity rates were higher in male patients (43.88%). The most prevalent Gram-negative isolate was (23.53 %), followed by (20.59%) and others. The only Gram-positive isolate was (21.57%). Most of the Gram-negative isolates were sensitive to imipenem, meropenem, ertapenem, ceftazidime-avibactam and aztreonam. Most of the gram-positive isolates were sensitive to linezolid and levofloxacin. The current analysis found that was the most often related bacteria to SSI, followed by , , and other infections. Periodic analysis of the causative organisms and their antimicrobial susceptibility pattern is necessary to confine the burden of SSI.

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A Study on surgical Site Infections, their bacteriological profile and antimicrobial susceptibility pattern

Cited by 4 publications

References 4 publications

Incidence, Antibiotic Susceptibility Pattern and Plasmid Profile of Bacterial Pathogens from Surgical site Infections in a Tertiary Hospital in Lagos, Nigeria

Incidence, Antibiotic Susceptibility Pattern and Plasmid Profile of Bacterial Pathogens from Surgical site Infections in a Tertiary Hospital in Lagos, Nigeria

A study on clinico-demographic and microbiological profile of surgical site infection (SSI) in a tertiary care hospital, Kolkata: An alarming trend

Bacteriological profile of surgical site infections and their antimicrobial susceptibility pattern at a tertiary care hospital, Western Gujarat

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